Proud of Kaisa Pakari @kpakari.bsky.social to receive the 2025 Schmeil young researcher award for her #PhD thesis. She established 🐟 models to address disorders of #glycosylation #CDG by advancing #baseediting range for precise genome editing @wittbrodtlab.bsky.social @cos.uni-heidelberg.de

new #preprint: mRNA delivered degron system w/ GFP-nanobody to efficiently reduce GFP-tagged proteins in an inducible manner in 🐟 Case study: reduction of PMM2 (basis for ER-based #glycosylation) causes hypoglycosylation reported from CDG-patients www.biorxiv.org/content/10.1... #CRISPR #RareDisease

Get ready for enzyme limbo & check out our new preprint: We knockdown Pmm2-GFP with a mRNA-delivered degron system in an inducible manner in medaka. Link: www.biorxiv.org/content/10.1101/2025.05.23.655727v1 Thanks to @thomthum.bsky.social, @wittbrodtlab.bsky.social & colleagues #greennomore #medaka

Calling all #MedakaPI researchers! Join us in Heidelberg, Germany from July 22-24, 2025 for our collaborative meeting! Register now & take advantage of early bird rates until April 15th! meetmedaka.com/registration/ 🐟 #MedakaResearch #ModelOrganisms #ScienceConference #FishModels #Heidelberg2025