Thrilled to highlight the brilliant work by Mandana Arbab, Zaneta Matuszek, with the Mouro Pinto and Liu labs — another major leap forward for somatic cell gene editing. 👏🧬 Base editing as a therapeutic strategy for repeat expansion diseases @NatureGenet nature.com/articles/s41...

At a major genome editing summit, spotlight turns to the value of human life www.statnews.com/2025/05/27/g... via @statnews.com

@laurensarko.bsky.social gave a great talk at #ASGCT2025: CRISPR-engineered CAR T cells targeting senescence-associated uPAR Clear, compelling science—and a great discussion that followed. Exciting to see where this work is headed. #CRISPR #CellTherapy @warfnews.bsky.social

Looking forward to this timely Scientific Symposium and conversation on #CRISPR #GeneEditing at #ASGCT2025! “Who’s Afraid of Off-Target Editing?” 1:30–3:15 PM CT (Room 293–296) With Claire Clelland (UCSF) & Kiran Musunuru (Penn) of @somaticediting Join us! #GenomicMedicine

Virus-free CRISPR knock-in of a chimeric antigen receptor into KLRC1 generates potent GD2-specific NK cells @sahakris.bsky.social www.cell.com/molecular-th...

Proud to have you represent!

Congrats to Giulia Scimonelli from the @sahakris.bsky.social Lab. The research award, funded by grants from Brittingham Wisconsin Trust, Knapp Bequest, and UW Division for Teaching and Learning, allows her to study T Cell Phenotype Enrichment Through mRNA Delivery for Enhanced CAR-T Manufacturing.

🌍 Excited to join the @UWMadison delegation in India for Badger Utsav II! We'll celebrate the opening of @BharatBiotech’s new gene & cell therapy facility. Grateful for this opportunity to connect & collaborate. #CRISPR ghi.wisc.edu/science-is-g...

🎉 Huge congrats to our newest PhD, Dr. Khajanchi (@omgitsnamita), on her stellar defense! 🌟 She delivered an outstanding presentation on her groundbreaking work developing a tunable #CRISPR genome editing system in human cells. Stay tuned for the preprint! 📄👏

🎓 Today at 10 am CT, join us at the DeLuca Forum or online for @omgitsnamita’s PhD defense on “Regulating Cas9 Genome Editor with Small Molecule Drugs.” 🌟 📍 @DiscoveryBldg 🔗 DM for Zoom link! #CRISPR

Please join me in congratulating @Shankar_K2, Ph.D. on her thesis defense! 🎓 By integrating #CRISPR genome editing w/ cell engineering, Dr. Shankar has crafted programmable cell therapies that are foundational to our lab’s new directions. @CMaT_ERC @UWCarbone @UWMadison_BME

Two PhD defenses this week: Join us! Orchard View, 3280, @WIDiscovery: @dcapps123 5/14: 2pm, Towards Efficient and Scalable Manufacturing of Genome-Edited CRISPR CAR T Cells @Shankar_K2 5/16: 2pm, Development of human natural killer cell-based immunotherapies via genome eng.

At #ASGCT2024, we're showcasing advances in non-viral gene editing, CAR T cell therapies, & high-throughput screening. Explore our work on vision restoration, cancer therapy, and ethical challenges in the field. Join us to learn about the latest progress in #GeneTherapy research

Join us this Thursday, Mar 21! A Question of Beginnings: Lab Embryos Between Nature and Synthesis with @jacob_hanna, @cartersnead, @ArnoldEisen, @SJasanoff, @JudyNorsigian, @jdhardin1959 + many more. @GenomeObserv Registration:

More momentum for CRISPR drugs! This time, it’s through direct injection of nanoparticles into the body.

Learn about the first approved #CRISPR drug and our own efforts to build on this breakthrough...tomorrow morning @WPR at 7:30am Central. Call in with your questions: 800-642-1234 @WIDiscovery @uwsmph @UWMadEngr @somaticediting @CMaT_ERC

The first authorized medicine for the #CRISPR field! The US FDA decision is likely to come next month. We are all hoping that post-market/approval data is shared and the durability of efficacy is at least many years, as seen in the clinical trials. ⁦

Finding resonance with many others thinking about global governance of emerging tech here at the #ParisPeaceForum2023. Come see our roundtable discussion on #CRISPR genome editing tomorrow.

It’s been a joy to develop & teach this hands-on #CRISPR lab course for @UWMadEngr. Read about our journey here. Our teaching assistants - Jamie, Anna, and @smerchette - provided invaluable input, and the students are quickly becoming expert gene editors!

Here is an excellent and ongoing discussion of a #CRISPR gene-edited cell therapy on the brink of approval. An important guidepost for our in vivo somatic editing efforts @somaticediting

Congratulations to all the 2023 JITC Best Paper Award Recipients! Especially to former Ph.D. students in our @UWMadison lab: @kpmueller1 + @NicoleJPiscopo (w/@CapitiniMD @UWCarbone @CMaT_ERC) for Best Immune Cell Therapies & Immune Cell Engineering Paper

We are hiring! Join the UW-Madison Biomedical Engineering department as a faculty member in a vibrant research community. 👇

The ecosystem for biotech here in Madison and Wisconsin is on the rise… @UWCarbone @UWMadison @Forward_BIO

Our new @somaticediting article describing an unexpected distribution of #CRISPR genome editing in the brain. These new delivery vectors can travel in surprising ways within tissues after injection. With Emborg, Levine, @GongShaoqin @uwsmph @UWMadEngr

Happy to participate as an expert for this excellent @USGAO report on the applications, challenges, and policy options for regenerative medicine. Lots of exciting work ahead... #CellTherapy #GeneTherapy #CRISPR @NASEM_Health @CMaT_ERC @somaticediting

We are lucky to have @danielevanbauer visit us on Monday! Join us at noon for his seminar on #CRISPR gene editing of blood stem cells. @UW_CHGPM @uwsmph @UWMadEngr @UWCarbone @UWMadScience @UWSCRMC @UWMadison_CGSI @WIDiscovery

🔬🧬 Join our groundbreaking journey as we pave the way for in vivo #CRISPR treatments in the clinic! 🌟 Madison, an incredible place to live and a flourishing tech hub, awaits your talent and expertise. 🌇 (thread 1/6 for two positions)

2023 Camp Champions: Jishnu Saha | Camp Casco

⁦Thank you @NPR⁩ ⁦@robsteinnews⁩ for covering this important #HGEsummit and highlighting contributions from ⁦our growing @GenomeObserv⁩ efforts. ⁦@UWMadison⁩ ⁦@ASU⁩ ⁦@HarvardSTS⁩ #CRISPR

The @somaticediting program and toolkit highlighted internationally here at #HGESummit by @ncats_nih_gov Director, Dr. Joni Rutter. Check out the data in the toolkit here:

Hiring! Looking for scientists and project managers - from academia and/or industry - who want to develop the next generation of #CRISPR cell/gene therapies. We have active grants aiming to move new nonviral drug candidates into first-in-human clinical trials. Please circulate.

Could #AI, data science, & systems thinking improve regenerative medicine? @NASEM_Health provides a vision here for incorporating these advances. w/Anne Plant, Kathy Tsokas, @SarahBeachy1 @KrishRoyLab @ClaudiaZylber @NicoleJPiscopo @SNSchumm @CMaT_ERC

Can the differences in our genes affect CRISPR drugs? Yes, and I discuss beautiful work on human genetic diversity in @NatureGenet by Cancellieri, @lucapinello, Dan Bauer, @shengdarqtsai+colleagues @somaticediting

Very happy to see our trainees get their well-deserved platform. More about her story is here:

#CRISPR editing of the brain...without viral vectors! We can deliver to neurons well via direct injection. Results independently replicated by a 3rd-party testing center @somaticediting @jacksonlab. @Musing_Naiad @Roy_Lab_Thinks @WIDiscovery @WARF_News

What an honor to mentor ⁦@Musing_Naiad⁩ on her journey! ⁦She is an invaluable member of and enriches our ⁦@somaticediting⁩ ⁦@WIDiscovery ⁦@UWMadison⁩ communities everyday.

Save the date! Join the @NASEM_Health #RegenMedForum on November 15 for a workshop, "Training the #RegenerativeMedicine Workforce for the Future". Register now:

Here is a nice summary of our T cell immunotherapy research with @CapitiniMD. We are moving closer to the clinic! This work was led by fantastic former doctoral students @kpmeuller @NicoleJPiscopo.

We're delighted to welcome @shengdarqtsai to campus this week. Please come check out his @UWMadison_CGSI seminar in person or virtually: Thursday 9/8 1:30 pm CDT CRISPR Genome Editing Technologies for Therapeutics @UWMadison @uwsmph @UW_CHGPM @somaticediting DM me for the link

Hear about our latest progress with T cells in @kpmueller1's @CMB_UWMadison defense on Monday. DM me for the Zoom link.

Join us to think through new directions for synthetic biology to improve heart, lung, blood, and sleep (HLBS) health. @nih_nhlbi Virtual Workshop in May with a fantastic group of speakers. Register for free here: draft agenda below

The molecular engineering in this article by the Maris lab and @yarmo111 is 🔥🔥🔥. One more reason to establish flexible manufacturing platforms for edited T cell immunotherapies. @CMaT_ERC

Congratulations, officially. Excited to see what you do next!

Finished an energizing @CMaT_ERC retreat today! A special day for the lab as @smerchette (with @melissa_kinney) @Shankar_K2 @kpmueller1 and Dan all receiving recognition today. Congratulations to all of these fantastic students! @WIDiscovery @UWMadison_BME @CMB_UWMadison

A worthy read, especially for practicing scientists who just want “to follow the science” (i.e., themselves) on policy matters

Tune in to @centraltimewpr to hear me discuss the *new* human genome and gene editing in about an hour (3pm Central):

Looking to control #CRISPR genome editing for therapeutic purposes? Check out our new @MolTherapy Review written by @omgitsnamita and me. Thank you to @somaticediting @CMaT_ERC, in particular @Roy_Lab_Thinks, for very helpful discussions.

Does anyone’s circadian rhythm in the summer align with 7:45am-2:45pm? Certainly not my kids this morning for their first day of school…

Congratulations🍾 for a successful doctoral defense, Dr. Kaivalya Molugu @KaivalyaMolugu! #WomenInScience a huge thanks to the committee, her local and global (🇮🇳) support network, and @WIDiscovery @UWSCRMC @CMaT_ERC @NIGMS

Now online & Open Access thanks to #SubscribeToOpen! Vol 23 of the Annual Review of Biomedical Engineering includes our article brilliantly written by @Amr_Abdeen, @itsbcos, @gersbach, & myself about #CRISPR, biomaterials, and genome editing @AnnualReviews