Julien Cherfils Vicini
@juliencherfils.bsky.social
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📥 350
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Team Leader @ircaninstitute Passionated by immunosurveillance to fight aging and cancer
reposted by
Julien Cherfils Vicini
CNRS Biologie
8 months ago
#RésultatScientifique🔎
| Vieillissement : un bouclier levé ?
@juliencherfils.bsky.social
et ses collaborateurs ont découvert comment un glycolipide protège les cellules sénescentes du système immunitaire. En le ciblant, ils parviennent à réduire les effets du vieillissement chez la souris ! 🧪
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Une nouvelle cible pour lutter contre les maladies chroniques liées au vieillissement
Le vieillissement entraîne une accumulation de cellules sénescentes qui échappent au système immunitaire et contribuent à des maladies chroniques telles que l
https://buff.ly/wsiwuEC
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Deeply honored by this News & Views!
doi.org/10.1038/s435...
Huge thanks to @Krizhanovsky, @Mejewska and
@NatureAging.bsky.social
for highlighting our paper
rdcu.be/d6wko
@ircaninstitute @Univ_CotedAzur
@CNRsbiologie.bsky.social
@Inserm.fr
@iltischarlene.bsky.social
@irynamoskalevska.bsky.social
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GD3 ganglioside checkpoints in immune surveillance of senescent cells - Nature Aging
Iltis, Moskalevska and colleagues investigate how the innate immune system regulates the age-related accumulation of senescent cells. They show that upregulation of the GD3 ganglioside-based immune ch...
https://doi.org/10.1038/s43587-025-00803-7
10 months ago
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reposted by
Julien Cherfils Vicini
Maria Ermolaeva
11 months ago
Study shows that senescent cells literally sugar-coat themselves to avoid recognition and clearance by the immune system.
www.nature.com/articles/s43...
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A ganglioside-based immune checkpoint enables senescent cells to evade immunosurveillance during aging - Nature Aging
This study identifies a novel immune checkpoint in senescent cells that is linked to the ganglioside GD3 and that contributes to the evasion of immune clearance by these cells and to aging and age-rel...
https://www.nature.com/articles/s43587-024-00776-z
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reposted by
Julien Cherfils Vicini
Not a porpoise but a ...
11 months ago
This paper, coupled with the Perspective from Neuron, really indicates that our understanding of the immune system on an aging brain could well be entering a new phase - one with lots of great data rather than mainly conjecture.
www.cell.com/neuron/abstr...
add a skeleton here at some point
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1/7 Excited to share our team’s first paper revealing how senescent cells use the GD3 ganglioside as a Senescence Immune Checkpoints (SICs) to bypass immune surveillance published in @NatureAging!
rdcu.be/d4XXJ
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A ganglioside-based immune checkpoint enables senescent cells to evade immunosurveillance during aging
Nature Aging - This study identifies a novel immune checkpoint in senescent cells that is linked to the ganglioside GD3 and that contributes to the evasion of immune clearance by these cells and to...
https://rdcu.be/d4XXJ
11 months ago
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What an incredible year! 🎉🚀 Huge thanks to my amazing team and collaborators! New talent, new lab under construction (moving in Jan 2025!), fantastic meetings (Chile, Shanghai) & paper accepted in @NatureAging (stay tuned!). Wishing everyone a Merry Christmas and an even more amazing 2025! 🎄✨
11 months ago
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