Genomes? Pah, who needs them... let's delete them!

actually courtesy of @arjunraj.bsky.social!

Heroic winner of the IgNobel prize for biology: paint zebra stripes on cows to stop them getting bitten journals.plos.org/plosone/arti...

. sjablonen 11 .

The failures of language in biology -- and the most apt description of biology I know: it is difficult to find a black cat in a dark room, especially if there is no cat. www.sciencedirect.com/science/arti...

'It’s not the destination, it’s the journey.' As true for stem cells as for humans!

I said some things about my PhD, and now they've appeared here. How fun!

Neuronal diversity is written in transcriptional codes 🧬. But what is the logic of these codes that define cell types and wiring patterns? To find out we built a #scRNAseq developmental atlas of the Drosophila nerve cord and linked it to the #connectome 🪰🧠 #preprint thread ⬇️1/8

Excited to share our paper on deciphering the design & control principles of tissue scaling w/ Luisa Arispe! Amazing work by co-first authors Danielle Pi and Jonas Braun. We show *differentiated* endothelial cell proliferate in waves with ultrafast cell cycle time of ~5h www.cell.com/cell-systems...

Just published: The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube A global temporal chromatin program, operating across the CNS, directs binding of specific spatial TFs & hence when/where neurons & glia are born authors.elsevier.com/sd/article/S...

No new genes needed to fly - just rewire what you have! 🦇🧬 Great new paper from the labs of @fany-real.bsky.social @stemundi.bsky.social @dariloops.bsky.social doi.org/10.1038/s415... #EvoDevo #SingleCell #BatWings

Measuring properties of individual cells in relation to their neighbors in 3D tissues is challenging. @cellysally.bsky.social &co develop a computational toolkit to facilitate this, analyzing developmental patterning in mouse, chick & #Drosophila #embryo @plosbiology.org 🧪 plos.io/4lQMeNu

genomebiology.biomedcentral.com/articles/10.... Quite an indictment of some of the current single cell "virtual cell" foundation models. Even for the relatively mundane applications, cell labeling, batch correction etc, they are poor compared to much simpler & cheaper methods.

Our latest "Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data" A rigorous mathematical foundation for Waddington's landscape to study cell fate decision making Applied to ventral neural tube development www.biorxiv.org/content/10.1...

Congratulations to Tiago Rito @ritolab.bsky.social starting his own research group at Hong Kong U