Latest update on #CROWN shows mPFS for lorlatinib still not reached at 7 years. Benefit across all subgroups including brain mets. This should push us to examine the paradigm: at what point does ‘incurable cancer’ become ‘chronic disease’? #ASCO26 #NSCLC #ALK #LCSM

Impressive improvement in PFS. Exciting option to bring targeted therapy forward into first line, delaying use of chemo. OS data still immature and rates of G≥3 tox high for Sunvoz, exceeding that of Chemo. Much to consider… #ASCO26 #LCSM

This news article gives a really clear lay-language summary of the pros and cons of #prostatecancer #screening. Well worth a read for blokes over 50 Yes there is a test. The test isn’t perfect. Risks outweigh the gains for most men who feel well and have no symptoms www.bbc.co.uk/news/article...

UK National Screening Committee report on #ProstateCancer balanced + evidence based No test is perfect, screening can do more harm than good Appreciate some are disappointed. The way forward is to develop better screening tests view-health-screening-recommendations.service.gov.uk/prostate-can...

It’s #ASCO26 week! @ascocancer.bsky.social Top picks that I’m excited about are: 1) HARMONi-6 OS results of Ivonescimab + chemo vs tislelizumab+chemo I’m 1° setting for advanced squamous NSCLC. Ivo data soo far has been promising, this could be a new SoC🫁 #lcsm #NSCLC #oncsky

It’s #ASCO26 week! 🦀 ASCO, run by @ascocancer.bsky.social is the biggest scientific conference in the world. Sometimes described as the Olympics of Oncology or WorldCup of Cancer Research. Much of the most impactful research of the year will be presented. My top picks and ones to watch to follow…

I’m a dual citizen 🇬🇧&🇳🇿. I have both passports - seems obvious and sensible to me UK rules changing. @theguardian.com mentions x4 in article below that ‘certificate of entitlement’ costs £589 They don’t mention the far cheaper option of renewing/getting a full UK passport for £94.50

I grew up in Dumfries & Galloway, highly reccommend it. Would be a great area to move to with a family. Rural and outdoor living but also under 90mins drive to Glasgow/ 2hours to Edinburgh

Happy New Year! I think this year is going to be a good year

Got a sandwich today from Britains iconic bakery chain: Greggs lady “did you ken there’s a Greggs Diet now?” Me “oh aye? Does it work?” Greggs lady “I’d have tae say No. Not if you’re wanting tae lose weight” #greggs #bakery #Diet #weightloss #healthyeating #newyear #resolution #scotland

‘Specialist of your choice’ is an odd criteria for hospital healthcare. People often don’t know which exactly which spcialist they need. A well run public system can triage anyone to the right place equitably Do you expect to pick your own pilot when you fly? (To be fair, @mcuban.bsky.social might)

Are you rich & don’t like paying taxes? Buy land!! Keir Starmer has decided to only charge inheritance tax to agricultural landowners on estates over £2.5million However if your only asset is a family home, you start paying inheritance tax at £325,000 What’s the point of this labour government?

It comes to my attention that Americans don’t use the word ‘tortoise’ & call #tortoises (ie the slow moving guys who sleep all winter) #turtles (ie the ocean dwelling dudes) and sometimes call them ‘land turtles’ 🐢 All tortoises are turtles. But not all turtles are tortoises. Tortoises are real

Remember to get your winter vaccine folks - it’s literally a potion that gives you more hit points.

In the long term a world with good, caring, benevolent AI will generate domesticated people and a comfortable stagnant era without innovation A world with antagonistic AI will generate inequality and injustice and strife and response and progress to the next thing beyond AI

Do other men have this problem? Sometimes I wear a suit that I think looks decent, and then realise I look like a mafia boss from the 1930s #fashionformen #strongmidsection #mob

Costco has nicely laid out produce & most folks go knowing what food they need for the week Health insurance is a deliberately confusing marketplace, and most people can’t be reasonably expected to know what they need Universal healthcare is the answer to this in every other wealthy country

$1Trillion is enough wealth for a million people to each become a millionaire It’s enough for 10million people to buy a small apartment and live in it It’s enough for 20million people to get a university education Nobody benefits from this much concentration of wealth Malignant capitalism

Happy Monday all, it’s Day4 of #ESMO25 My hot picks for today: ✅Updated data on #SWOG1801 & #NADINA ✅#SafeStopTrial (early discontinuation of CPI in CR/PR) ✅#STAMP (adj pembro in Merkel Cell) ✅Phase1 #IMA203 for 👁️Uveal Melanoma in Presidential session @oncoalert.bsky.social @myesmo.bsky.social

#HARMONi-6 & #OptiTROP-Lung04 both large phase-3 RCT in a china🇨🇳 only population. Both given Presidentials #ESMO25 Discussants commented re confirmatory trials in worldwide setting Is this necessary in 2025? Why don’t we consistently raise this question to EU/US trials?🇪🇺🇺🇸 #oncology #LCSM #oncsky

#OptiTROP-Lung04 🫁Sac-TMT (Trop2 ADC) vs Pt doublet in EGFR mutant #NSCLC 2nd line after targeted therapy mPFS 8.3 vs 4.3months mOS Not Reached vs 17.4months No ILD/pneumonitis. G3 Tox similar in both arms Exciting option, in a challenging setting #ESMO25 @oncoalert.bsky.social #LCSM

#HARMOMi-6 🫁Compared Ivonescimab (PD-1 + VEGF bispecific) vs Tizlelizumab (PD1) in combo ŵ Chemo in 1st line setting for squamous #NSCLC mPFS = 11.1 vs 6.9 months Benefit preserved across subgroups including PD-L1<1% OSdata awaited… No increase in tox This data is exciting #ESMO25 @OncoAlert

#ESMO25 Adam Gripping of @mdanderson.bsky.social discusses association of improved OS in #NSCLC and #Melanoma with administration of a mRNA COVID vaccine Translational work showing mechanism of increased INF-alpha leading to immune priming Phase III in development… @oncoalert.bsky.social

Good Morning Berlin! it’s day 3 of #ESMO25 My top picks today are: 🫁 HARMONi6 - Ivonescimab vs PD1 1st line in #NSCLC 🫁OptiTROP-Lung04 - sac-TMT in EGFR mutant NSCLC post TKI 🩻DREAM3R - Durva+CT 1st line in #Mesothelioma 🏌️ENZARAD (ANZUP 1303) - ADT + RT #LCSM @oncoalert.bsky.social

#RAMPART demonstrated improved disease free suvivival at three years in resectable Renal Cell Carcinoma with addition of adjuvant #Durvalumab and #Tremelimumab 3year DFS 81% vs 73% for surveillance Nb increased tox, including myocarditis #ESMO25 @oncoalert.bsky.social

In KEYMAKER-U03 addition of Belzutifan shows potentially improved PFS (31.8 vs 20.8 months) compared to standard Len/Pem in metastatic #RCC. Phase 3 Litespark-12 will further inform practice #ESMO25

ts Day 2 #ESMO25! Today I am looking forward to: 🫁#DeLLphi-303 1st line Tatlatamab in SCLC 🫘#RAMPART from James Larkin on adjuvant IO in RCC 👁️#PLUME Len/Pem in uveal melanoma ⭐️Special Session on PeriOperative strategies from Sapna Patel & others @myesmo.bsky.social @oncoalert.bsky.social #LCSM

#FLAURA2 analysis of exploratory subgroups shows mOS benefit in: 🧠 brain mets (40.9 v 29.7months) 🥃liver mets (36.6 vs 28months) 🦴bone mets (40.2 va 32.3 months) 🧬ctDNA positive (38.4 vs 32.5 months) Confirms #FLAURA2 approch valid as a SOC in these groups #ESMO25 #LCSM

#ALEX study shows 81.1 month median OS in final report of study from Tong Mok Amongst the longest overall survivals reported in lung cancer. Further trials of 3rd and 4th gen TKI ongoing. Much work to do, but valuable to reflect on how far things have com #ESMO25 #LCSM #Alk #NSCLC

Phase 2 #NORTHSTAR presented by @YYElamin: improved PFS ŵ addition of local consolidative therapy (Sx or RT) after initiation of Osimertinib for #NSCLC. Acceptable safety profile. Benefit in Oligo & poly metastatic disease. Exciting pathway to explore further... #ESMO25 #LCSM #Oncsky #Medsky

@ESMO day1 #ESMO25 Today looking forward to: -Session on optimising peri-operative IO from @MartinReck2 -ReCIPE-M1 study from Jacob Orme -session on emerging options beyond CPI chsired. Y Ines Pires de Silva -Final ALEX data from Tony Mok and Beamion data from Sanjay Popat @myesmo.bsky.social

Anecdotally I have arrived in #Berin #Germany, to attend #ESMO25 but the data is immature, and not powered for formal statistical analysis. Longer follow up, and further studies are required #oncsky #Medsky #LCSM

Less than 48hours until #ESMO25! Lots of exciting content ahead. Looking forward to seeing colleagues old and new. Who else is going to Berlin this week? @myesmo.bsky.social #oncsky #cansky #medsky #LCSM

For those of you wondering why newer antibodies are now called -tugs -barts -migs and -ments not -mabs, this is the official @who.int INN explainer tinyurl.com/49bxfn4t

Highly recommend this event. I had the opportunity to go last year - excellent for learning and great networking #LCSM #Oncsky #MedSky 🫁🫁

🫁Reduced smoking rates have prevented 3.8million lung cancer deaths in USA alone since 1970 Not all lung cancer is caused by smoking, but a large portion of it is. Public policy can be very effective. All countries should move towards net zero tobacco #LCMS #medsky #Oncsky doi.org/10.3322/caac...

60y/o man with bromide induced psychosis after consulting with ChatGPT on how to improve his diet 🧂🥦. ***For anyone in doubt, do not ask AI for medical advice. Even the best tools are dangerous when used for the wrong job*** #medsky #AI #ChatGPT #Bromide www.acpjournals.org/doi/epdf/10....

Phase I/II of an oncolytic immunotherapy + Nivo for anti-PD1-Refactoy melanoma 👉Stage 4 Cutaneous 🦠ORR 32.9% 🦠 median DOR 33.7months 🦠Response in injected + non-injected lesions 🦠G3/4 tox 12.9% Exciting prospect in difficult setting Phase III already underway… #oncsky #medsky #melanoma #IO #virus

A careful version of this (exemptions for children, elderly, pregnancy etc) is not necessarily all bad Many GP practices are basically local small businesses owned by the doctors who work there In Australia & New Zealand patients pay a small fee to see GP, both have great public healthcare systems

Duolingo, when is this sentence going to come up in conversation?? (¿Por qué eres tan duro con Pedro?) @duolingoverde.bsky.social #duolingo #spanish #español #dog #perro

Bills in progress indicate your elected representatives are voting for this batshit madness Soo many politicians have a legal or economic skillset, but very few are scientifically or medically literate One way to get politics out of science would be for more scientists to get elected into politics

🤖Robotic AI Surgeons? Guardian article anticipates within 10 years. Extrapolates a trial of 8 post-mortem procedures on animal models. Amazing work, but I see huge regulatory barriers before roll out of AI surgery, not to mention massive issues with acceptability to patients🤖 #medsky #AI #surgery

Never fear a challenge, but seek hazardous adventure ⬆️This advice from a colleague has been on my mind all day #medsky #life #career #personalgrowth

Heartbreaking read (and caution needed as facts may come to light in Inquest) I’ve seen other cases similar, all end tragically We should instill scientific method & critical thinking in every level of education. Make a generation who have tools to assess information & see scams/cults as they are

It’s World Kidney Cancer Day Show your kidneys some love #Cansky #oncsky #kidney www.worldkidneycancerday.org

Who says my job isn’t glamorous: #medsky #mucositis

#American #democracy will not die with a bang. There will not be a cardiac arrest to resuscitate You will soon look back and realise that it slipped away quietly months ago, insidious, hard to even say which was the final blow. The #Republic will end as quietly as the next breath that does not come

De-escalating cancer treatment can be challenging for clinician & patient, but important esp in curative setting This trial in #breastcancer shows no benefit from post-op RT when N1 involved nodes show pCR following neo-adjuvant chemo. For once, the lack of curve separation is good news!

My iPhone autocorrects Nigel Farage to Nigel Garbage. I’m fine with this

Why does immunotherapy appear to be more effective early in the day? More work to be done but many aspects of immune system follow circadian rhythm, including dendritic cell migration and entry of circulating tumour cells to circulation #ImmuneOnc #Oncsky #IO #medsky jitc.bmj.com/content/13/3...