Anecdotally I have arrived in #Berin #Germany, to attend #ESMO25 but the data is immature, and not powered for formal statistical analysis. Longer follow up, and further studies are required #oncsky #Medsky #LCSM

Less than 48hours until #ESMO25! Lots of exciting content ahead. Looking forward to seeing colleagues old and new. Who else is going to Berlin this week? @myesmo.bsky.social #oncsky #cansky #medsky #LCSM

For those of you wondering why newer antibodies are now called -tugs -barts -migs and -ments not -mabs, this is the official @who.int INN explainer tinyurl.com/49bxfn4t

Highly recommend this event. I had the opportunity to go last year - excellent for learning and great networking #LCSM #Oncsky #MedSky 🫁🫁

🫁Reduced smoking rates have prevented 3.8million lung cancer deaths in USA alone since 1970 Not all lung cancer is caused by smoking, but a large portion of it is. Public policy can be very effective. All countries should move towards net zero tobacco #LCMS #medsky #Oncsky doi.org/10.3322/caac...

60y/o man with bromide induced psychosis after consulting with ChatGPT on how to improve his diet 🧂🥦. ***For anyone in doubt, do not ask AI for medical advice. Even the best tools are dangerous when used for the wrong job*** #medsky #AI #ChatGPT #Bromide www.acpjournals.org/doi/epdf/10....

Phase I/II of an oncolytic immunotherapy + Nivo for anti-PD1-Refactoy melanoma 👉Stage 4 Cutaneous 🦠ORR 32.9% 🦠 median DOR 33.7months 🦠Response in injected + non-injected lesions 🦠G3/4 tox 12.9% Exciting prospect in difficult setting Phase III already underway… #oncsky #medsky #melanoma #IO #virus

A careful version of this (exemptions for children, elderly, pregnancy etc) is not necessarily all bad Many GP practices are basically local small businesses owned by the doctors who work there In Australia & New Zealand patients pay a small fee to see GP, both have great public healthcare systems

Duolingo, when is this sentence going to come up in conversation?? (¿Por qué eres tan duro con Pedro?) @duolingoverde.bsky.social #duolingo #spanish #español #dog #perro

Bills in progress indicate your elected representatives are voting for this batshit madness Soo many politicians have a legal or economic skillset, but very few are scientifically or medically literate One way to get politics out of science would be for more scientists to get elected into politics

🤖Robotic AI Surgeons? Guardian article anticipates within 10 years. Extrapolates a trial of 8 post-mortem procedures on animal models. Amazing work, but I see huge regulatory barriers before roll out of AI surgery, not to mention massive issues with acceptability to patients🤖 #medsky #AI #surgery

Never fear a challenge, but seek hazardous adventure ⬆️This advice from a colleague has been on my mind all day #medsky #life #career #personalgrowth

Heartbreaking read (and caution needed as facts may come to light in Inquest) I’ve seen other cases similar, all end tragically We should instill scientific method & critical thinking in every level of education. Make a generation who have tools to assess information & see scams/cults as they are

It’s World Kidney Cancer Day Show your kidneys some love #Cansky #oncsky #kidney www.worldkidneycancerday.org

Who says my job isn’t glamorous: #medsky #mucositis

#American #democracy will not die with a bang. There will not be a cardiac arrest to resuscitate You will soon look back and realise that it slipped away quietly months ago, insidious, hard to even say which was the final blow. The #Republic will end as quietly as the next breath that does not come

De-escalating cancer treatment can be challenging for clinician & patient, but important esp in curative setting This trial in #breastcancer shows no benefit from post-op RT when N1 involved nodes show pCR following neo-adjuvant chemo. For once, the lack of curve separation is good news!

My iPhone autocorrects Nigel Farage to Nigel Garbage. I’m fine with this

Why does immunotherapy appear to be more effective early in the day? More work to be done but many aspects of immune system follow circadian rhythm, including dendritic cell migration and entry of circulating tumour cells to circulation #ImmuneOnc #Oncsky #IO #medsky jitc.bmj.com/content/13/3...

Relationship status impacts cancer survival @ascocancer.bsky.social Colorectal cancer 5year OS 62.1% if married vs 44.6% if divorced/widowed. 17.4 % OS advantage ??Prospective trial of adjuvant marriage?? Increased support beyond those traditionally thought vulnerable may be needed. #oncsky

🌟🌟CHALLENGE trial: 3year structured exercise program after adjuvant chemo improved DFS (ie. Alive & cancer free) in stage II/III colon cancer 5year DFS 80.3 vs 73.9%, HR 0.72 Amazing work, needs to be repeated in other tumour streams and paradigms #Oncsky #Cansky #Medsky #exercise #survivorship

Arrived home to find a copy of #ADifferentKindOfPower by truly great New Zealander @jacindaardern.bsky.social on my doorstep. Excited to give it a read - update will follow #NewZealand #NZ #booksky #Power #kindness #aotearoa

Multiple oral abstracts & posters @ascocancer.bsky.social present evidence that Time of Day impacts on effectiveness of immunotherapy. With morning administration improving outcomes Easy to implement 👍 No additional $$ cost 👍 Tolerable for most patients 👍 #Oncsky #Medsky #Cansky #LCSM #IO

Almost time for @ascocancer.bsky.social. Will be watching online this year. Especially interested in: •CM816 OS data @patrickforde.bsky.social •NeoADAURA •DeLLphi-304 •SOHO-01 @herbloongmd.bsky.social •RELATIVITY-098 @gvlongphdmd.bsky.social •DANTE phase III #LCSM #melanoma #oncsky #medsky #ASCO

New job. Now at the Royal Marsden Hospital in London. Still treating and researching #melanoma and other skin cancers. Now also treating and researching #RenalCell cancer. #oncsky #cansky #medsky #UK #NHS

There is always good news when we look for it

Exciting news for #Melanoma in #NewZealand. First ever public funding of BRAF/MEK inhibitors, & funding of Pembrolizumab in resectable stage III disease. This will save lives up and down the motu, provided there are enough doctors, nurses and health service capacity to deliver it. #oncsky #medsky

Blessed to have mentors who are the driving force of lung cancer research in New Zealand @anmwongnz.bsky.social & Laird Cameron. #NewZealand #LCSM #Oncsky

Everything is Tuberculosis by @johngreensbluesky.bsky.social Thoughtful writing on how society engages with disease, and how illness effects society Short enough to read on a flight. Concise arguaments & keeps swift pace. Would be accessible for a young person with a curious mind #TB #VirtousCycle

Goodbye for now New Zealand. You’ve been excellent. And so have I. Onwards #Aotearoa #NewZealand #NZ #ThankYou #onwards

Hello Wellington. Can’t beat it on a good day! #NewZealand #NZ #Wellington #Aotearoa

Love the conversations I get to have: “Is there anything else I can sort out while you’re here in oncology clinic Mr 82y/o?” “Nah… Yeah.. actually Doctor, what are Bao Buns? I keep seeing them but don’t know if I want to try one” #medsky #oncsky #communication #Priorities #BaoBuns

As many countries set up or consider lung cancer screening programmes, we will see more early stage disease. Neo-Adj Chemo-IO increasingly SoC for resectable disease. It is timely to consider optimal sequence for likely biologically similar non-resectable disease #LCSM #OncSky #MedSky #IO

7year intracranial PFS 42% with 1st line Ipi/Nivo for melanoma with asymptomatic brain mets Incredible progress. Increasingly paradigm in met melanoma not truly palliative, but long term disease control. Challenge remains to increase rate of durable responses #medsky #Oncsky #melanoma

🫁Given the choice, I would use lorlatinib first line. PFS sufficiently impressive to accept and manage tox profile. With long PFS we may not get a clinically relevant sequencing trial. 4th Gen agents should be compared against lorlatinib as current standard of care. #LCSM #Oncsky #Medsky

Phase I/II of Nivo vs Ipi+Nivo in advanced Merkel Cell Carcinoma Similar efficacy in both groups, ORR 60 vs 58%. ++toxicity with Ipi No benefit to adding Ipi in this study, but important to ask the question in a rare cancer #Oncsky #MedSky #Immuneoncology #RareCancers doi.org/10.1200/JCO-...

Safety of anti-PDL1/PD1 in a solid organ transplant recipient? Some retrospective case series out there. Recent report hints PDL1 may be less accociated with rejection than other classes Does anyone have experience or insights? #oncsky #LCSM #Melanoma #IO #ImmuneOncology

31/365 1 month into exercising every day of 2025 I still have the body shape of a potato, but you gotta start somewhere. So far: energy up, sleep improved and enjoying the change in routine #fitness #gym #health #weightloss #newyearsresolution #fitnesssky #gymsky

Pooled safety data on Sotorasib from 4 studies w combined cohort of 549 Hepatotoxicity 9.9% in those unexposed to immunotherapy vs 24.8% if any prior exposure. 33.3% if given IO within 3months of starting sotorasib Noteworthy as some trials look at #IO + KRAS combo #LCSM #oncsky #Medsky #KRAS

O wad some Pow'r the giftie gie us To see oursels as ithers see us! It wad frae mony a blunder free us, An' foolish notion: What airs in dress an' gait wad lea'e us, An' ev'n devotion! #RobertBurns #BurnsNight #Scots #Scotland #Alba #Haggis 🏴󠁧󠁢󠁳󠁣󠁴󠁿

Any haematology friends on #Bluesky? I’m thinking about everyone’s favorite 4th line anticoagulation agent Fondaparinux… Is the letter ‘x’ supposed to be silent? Or is this a local thing I picked up where I trained? #Haemsky #Medsky

Our revels now are ended President #Biden, appearing frail, channels Shakespeares Prospero in his farewell speech from the Oval Office Stark and surprisingly blunt warning on the rise of the #oligarchs and future of #America

Headline looks scary, but there will surely be advantage for the 1st country to open up government data to #AI Risk of mismanagement is high Best security measure would be a law requiring equity and board membership from companies seeking to develop based on public sector datasets #Medsky #UK

High doses of vitamin C, high doses of vitamin D, ivermectin, and fenbendazole have recently been promoted both domestically and internationally as the “new recipe” for cancer treatment. However, such approaches are nothing more than exploitation of people’s hopes with unproven methods.

Adult survivors of childhood cancer are at greater risk of developing, and dying from #melanoma Effect driven by exposure to cyclophosphamide, bleomycin, & RTx >40Gy Important to address and educate on other modifiable risk factors: #UV #SunProtection and skin self-check #cansky #oncsky #medsky

Facebook is the network of choice for an older generation who are not well equipped to identify #misinformation and #disinformation It’s time have a talk with your parents about where information comes from… www.bbc.com/news/article...

CheckMate-067 10year final analysis: Ipi/Nivo: 📍median Melanoma Specific Survival=NOT REACHED at 120months 📍mOS=71.9months 📍For those alive @ 3years, melanoma specific survival at 10years=96% 📍No new safety signal >5years Cure for some #Oncsky #Cansky #Melanoma #IO www.nejm.org/doi/full/10....

#AI to assess generalisability of trials by emulating landmark studies in real world dataset Patients with high risk presentations may benefit less Some limitations in methodology, but interesting conversation to have about #applicability of trials & #IndividualisedMedicine #LCSM #oncsky #medsky

So that’s it for 2024! Personal highlights: -trip to Washington DC (minus the food poisoning) 🦅 -Travel to #Iceland 🇮🇸 -Suprise visit to the family in #Scotland 🏴󠁧󠁢󠁳󠁣󠁴󠁿 -Sworn in as a new Citizen of #NewZealand 🇳🇿🥝🩴🐑 Wherever you are today I wish you all the very best for 2025!