Lydia Newton
@lsnewton.bsky.social
📤 64
📥 78
📝 3
Postdoctoral Research Fellow in the Towers Lab at UCL
@towerslab.bsky.social
pinned post!
My PhD work is now published! We designed PROTACs that degrade the viral cofactor CypA and demonstrated their antiviral activity against HIV & HCV. We anticipate broad efficacy against unrelated viruses and reduced evolution of viral resistance. They also make excellent tools to probe Cyp biology.
add a skeleton here at some point
10 months ago
2
20
2
reposted by
Lydia Newton
Towers Lab
2 months ago
New preprint from our lab, led by our postdocs Dara Annett and Kate Morling in collaboration with Selwood Lab! We developed a modified cyclosporine, BG147, which enhances lentivector gene therapy transduction, ex vivo in HSPC and in vivo in mouse photoreceptors, by degrading IFITM3. Check it out!
loading . . .
A modified cyclosporine enhances lentivector transduction ex vivo and in vivo by degrading IFITM3
Intrinsic innate immune barriers have evolved to suppress viral infection and can reduce effective gene delivery in gene therapy. We have developed BG147, a novel cyclosporine A analogue, optimised vi...
https://www.biorxiv.org/content/10.1101/2025.08.26.669098v1
0
12
7
reposted by
Lydia Newton
Towers Lab
5 months ago
We are delighted to be joining the Blizard Institute in Autumn. The Blizard Institute is an amazing place for discovery science and we're looking forward to more transformative research and collaborations.
www.qmul.ac.uk/blizard/abou...
loading . . .
Blizard Institute welcomes world-leading team of virologists
https://www.qmul.ac.uk/blizard/about/news/items/blizard-institute-welcomes-world-leading-team-of-virologists.html
2
26
9
reposted by
Lydia Newton
Mohamed Elghazaly
6 months ago
Towers Lab attending
@londoninfectionecr.bsky.social
(LINE) annual symposium. Great talk lineups at the Francis Crick Institute, London.
#LINE
#ScienceIsCool
.
0
9
3
reposted by
Lydia Newton
RM
7 months ago
Virtual Virology is back - our first ever phage session. Do join us...
2
22
15
reposted by
Lydia Newton
Towers Lab
9 months ago
Great seeing our recent antiviral PROTAC paper chosen by Nature Comms Editors as one of the 50 best papers in Microbiology and Infectious Diseases!
www.nature.com/collections/...
loading . . .
Microbiology and infectious diseases
This page highlights recent articles on all aspects of bacteriology, mycology, parasitology and virology, covering the biology of pathogens, host-pathogen ...
https://www.nature.com/collections/jedgcgeija
0
10
2
reposted by
Lydia Newton
Nature Communications
9 months ago
Antiviral drug development: Small molecules inducing degradation of host protein cyclophilin A show
#antiviral
activity against HIV-1 & HCV
@towerslab.bsky.social
@lsnewton.bsky.social
@claragathmann.bsky.social
@jollylab.bsky.social
@alessiociulli.bsky.social
www.nature.com/articles/s41...
loading . . .
Macrocycle-based PROTACs selectively degrade cyclophilin A and inhibit HIV-1 and HCV - Nature Communications
Targeted protein degradation has so far been rarely applied as an antiviral strategy. Here, the authors report that macrocycle-based PROTACs targeting host protein cyclophilin A, exploited during vira...
https://www.nature.com/articles/s41467-025-56317-8
0
11
3
My PhD work is now published! We designed PROTACs that degrade the viral cofactor CypA and demonstrated their antiviral activity against HIV & HCV. We anticipate broad efficacy against unrelated viruses and reduced evolution of viral resistance. They also make excellent tools to probe Cyp biology.
add a skeleton here at some point
10 months ago
2
20
2
reposted by
Lydia Newton
Gabi Heller
10 months ago
Today
@gogs-k.bsky.social
,
@tlhr.bsky.social
, and I are launching
@bindresearch.org
, a UK-based not-for-profit research startup to deliver publicly–available tools and datasets to make intrinsically disordered proteins druggable. 🍝 💊🧲 💻 🦠
3
75
21
you reached the end!!
feeds!
log in