Happy to announce the publication of our paper in Science Immunology. Here we describe the first patients with biallelic disease causing mutations in the LTBR gene encoding for the lymphotoxin beta receptor. 1/10 www.science.org/doi/10.1126/...

New in #ScienceImmunology: Research from @boztugk.bsky.social and team identifies an inborn error of #immunity caused by human LTβR deficiency, resulting in defective stromal cell signaling and impaired humoral immune responses. Read more: www.science.org/doi/10.1126/...

💡 Newly found genetic defect! In their study published in Science Immunology, @boztugk.bsky.social and @bernhard-ransmayr.bsky.social describe how LTBR-mutations disrupt secondary lymphoid organs, causing severe Immune Deficiencies (IEI). 🔗 tinyurl.com/57mmv5v7