Medicine shifts overnight. 15% of CRCs are dMMR. Surgery was standard—until now. Diaz, Cercek @mskcancercenter.bsky.social @nejm.org: dostarlimab = 82% CR, 92% RFS, low toxicity. Immunotherapy first. Surgery backup. Paper: nejm.org/doi/full/10.1056/NEJMoa2404512 #Lynch #CRC #Immunotherapy

COOLEST THING IN MICROBIAL MEDICINE THIS WEEK 🔬🧫 New research in Nature suggests early-onset colorectal cancer (EOCRC) might be increasing due to childhood colonisation by colibactin-producing bacteria. A thread on this fascinating discovery... 🧵 #MicrobialMedicine

“Back then, the overwhelming public sentiment was: never again. Today, it seems: never what?”—Siddhartha Mukherjee Exceptional essay Gift link www.nytimes.com/2025/03/10/o...