Biosynthesis, Structure, and Antibiotic Properties of Gelatinamin A, a Triculamin-like Lasso Peptide https://www.biorxiv.org/content/10.64898/2025.12.02.691826v1

Thanks for a great colab Marc!

>80 grams of engineered lasso peptide from 20 L E. Coli fermentation broth. This and more amazing results from Lassogen in preprint.

We are excited to see our review published! In it, we explore the diversity of enzymatic strategies for installing aromatic side chain cross-links in RiPPs. If you like interesting chemistry and new enzyme reactions, be sure to check it out!

I’m not entirely sure how these starter packs work… but I’ve created one for microbial natural products - hopefully it helps us connect! go.bsky.app/72NeGsT

A Christmas present to all of the lasso peptide connoisseurs out there. The next chapter in our work is on triculamin is ready on bioRxiv. Great work by two incredibly talented graduate students @amerrild.bsky.social and @tizianasvenningsen.bsky.social. www.biorxiv.org/content/10.1...