I'll be at #ASHG24 this week with @fulcrumgenomics.bsky.social and my #Rust -colored glasses...find (or DM) me if you want to talk bioinformatics, Rust, basketball (Go Warriors!) or pretty much anything except politics.

Guy complaining about how "every kid gets a trophy these days" while drinking out of his "Worlds's Best Dad" mug.

Never, ever, ever trust benchmarks when the person doing them also has an interest in one of the things being benchmarked. It's the same logic as not wanting the person who implemented the code to be the (only) one testing it.

Ohhh...this is very cool

Does being XX lead to more autoimmune disorders than XY? Here's my story on a chromosomal mystery. Gift link: www.nytimes.com/2024/02/01/h... 🧪

Damn good title. Bravo. www.biorxiv.org/content/10.1...

Dear 23 and Me -- I realize times at tough for you right now, but preventing people from downloading their own data is not OK

IMO this is the most exciting news coming out of this year's AGBT. Anyone have anything better? (Please don't reply with "Ultima") seqwell.com/seqwell-and-...

I have no idea what the demographics are for people who listen to metal, but it's gotta be like 90% parents, right? I mean how else do you guys cope?

The best Internet hack I've seen in a while. It actually works. 😯 "If you add “cooked.wiki/“ to beginning of ANY recipe URL (before the https:/) it strips away everything but the recipe and organizes the ingredients and method into separate columns." stolen from theblower.au/@Maxton/1117...

I'm happy to announce the release of WDL 1.1.1! This patch release includes many improvements to the specification. Read all about it on WDL's new blog: dev.to/openwdl/anno...

VC money is a poisoned chalice, avoid until unavoidable

Let’s say you’re a biotech founder raising money. You meet with someone from a VC firm who literally believes we have the ability to “uplift other species” (maybe someone gave him a David Brin novel and forget to tell him it’s Sci-Fi). Under what circumstances to you take their money?

If you are looking to use Rust for Advent of Code, this repo is a nice template for the boilerplate setup used each day: github.com/sstadick/aoc... #rust #adventofcode

I forgot how amazing this stuff is! Found a bottle with a finger left in it and I’m kicking myself or not buying more before I left Maryland.

Really excited about monaspace, but... Huge missed opportunity to name their new technique "Textural Healing"

The new Awk book second edition arrived today. Awk's enduring relevance is amazing. The first ed. of the book was published before I was born and despite (because?) its age I use Awk everyday and encourage all our students to learn it. Here are my Awk slides/colab: docs.google.com/presentation...

A good test to see if you’re writing maintainable code is to re-read it six months later. Both pandas & tidyverse fail this test, unless I add copious comments about the shape/content/schema/types of the data frames after each transform. Comments should not replace data structures and typing…

It's too bad, I really liked eLife. Will no longer consider reviewing or submitting there.

So incredibly disappointed and disturbed by what elLife has done here x.com/mbeisen/stat... And yes this is my brother who they fired for posting a link and a comment about an Onion article. But I can say without any bias what they did was idiotic and wrong.

I'm looking for an Evil BAM file. By Evil, I mean all the weird cases every bioinformatician has seen at some point and gone "Oh $*%!, I forgot to handle that case in my code!" If this doesn't exist then we should make it happen. Really needed for testing genomics tools.

Rust folks - how are you using const generics in the context of command line tools? For example, I’m looking at using the Kmer struct in github.com/COMBINE-lab/..., which is parameterized by K (kmer size). In my CLI, K is an option set by the user, so it’s not known at compile time. What do I do?