Glomerular basement membrane (GBM) structural integrity dictates trans-tissu... www.sciencedirect.com/science/arti... Really proud of this Cell Reports paper showing that the potentially pathogenic laminin alpha2 in the Alport GBM comes not from glomerular cells, but from the bloodstream.

Great collaboration! So happy that our O'Brien Kidney Center Variant Validation Core could help out with the VUS analyses. @washunephrology.bsky.social @obrienkidney.bsky.social

Your ASN-AHA Young Investigator Award seems like yesterday! Congratulations on the 2-peat!

This makes me very curious about the COL4A5 variant!

Highlights from my talk yesterday on Alport syndrome spectrum of disorders. (since no one posted it, I'll have to do it myself) Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵

Thanks to Julie Inglefinger for this enlightening summary at ASN KidneyCure Week!

I’ll be there!

Spreading the word about the Importance and Power of Podocytes at @asnkidney.bsky.social Kidney Week in Houston. @isgd.bsky.social

Thanks to NIDDK for funding this work! #AlportSyndrome @alportuk.bsky.social @alportalliance.bsky.social

I first presented the data in this paper at the Philly Podocyte meeting in May 2023 (thanks @ksusztak.bsky.social & Larry Holzman), and a few days ago the paper appeared in @kidneyint.bsky.social . Promising results for new ways to treat Alport syndrome. kidney-international.org/article/S008...

Structurally beautiful--and beautifully functional, too!

📢 Ready to take your research further? The 2026 KidneyCure Grant cycle is open. Funding, mentorship, and resources are waiting. Applications close on Thursday, November 20, at 2:00 p.m. EST. Programs support fellows, PhD students, and early-career faculty in kidney care: bit.ly/kcgrantsfund...

Congratulations Stephen! I look forward to hearing your talk in Baltimore in November at ASMB 2025! @amsocmatbio.bsky.social

🚨 Final call: The ASN Loan Mitigation Program closes tomorrow, Wednesday, August 20, at 2:00 p.m. EDT. Get your application in for a chance at $50K over three years toward student loans to reduce your debt and focus on your career in kidney care. 👉 bit.ly/lmp2025

Very happy that Kidney News published my call for a kidney care revolution. Thank you to @asnpublications and everyone who has guided me along the way.

Check out my article on Alport syndrome in the July ASN Kidney News: "From Basement Membrane Thinning to Alport Syndrome: An Array of Presentations Caused by COL4A3/A4/A5 Gene Variants" www.kidneynews.org/view/journal...

🗳️ Voting for the ASN Council Election is now open! Select the next Executive Councilor and At-Large Councilor. Your voice helps shape what’s next in kidney care. Deadline: Friday, September 5, at 11:59 p.m. EDT 🔗https://www.asn-online.org/vote

Thrilled to have this finally published! If you are interested in learning about the collagen IV diseases Gould syndrome and Alport syndrome, add this to your reading list. www.nature.com/articles/s41...

One of my favorite sessions in Hamburg!

Congratulations Moe!!!

Joshua's story about living with APOL1-associated diasease inspired Dr. Katalin Susztak to present the connecting bridges from mapping to mechanisms to medicine! 💊 More results at the next #PodocyteConference? 🤩

Talked to @KateZernike at @nytimes about my journey and the current moment for scientists in the U.S. “Ardem Patapoutian’s story is not just the American dream, it is the dream of American science.” Read the article here. No subscription required: www.nytimes.com/2025/06/03/u...

Just attended a terrific meeting on Alport Syndrome So many talented experts in the room + the most involved patients. And so much hope for progress towards new treatments.

The OKRA National Forum is happening tomorrow from 12-1pm CST / 1-2pm EST! Dr. Naoka Murakami (WashU) will be discussing “T cells in Kidney Wells: Lessons from Immunotherapy-associated Kidney Injury.” Learn more and register at our website: www.uab.edu/okra/trainin...

A bright spot regarding NIH: A colleague whose R01 scored 5% in July 2024, with an expected September 2024 start date, finally received the Notice of Award today, with only a standard administrative budget cut. The wheels really are turning.

#JOIN us #TOMORROW for an exciting e-symposium exploring the critical role of the #ECM in #womensHealth Register⏩http://asmb.net/e-symposia #ECMatrixIsEverywhere #WomensHealth #MeetTheOrganizers: Dr. Pilar de la Puente (@delapuente_lab) & Dr. Maria Gonzalez Porras (@GonzalezPLab)

A great collection of people and passion at the @asnkidney.bsky.social @ahascience.bsky.social Saving Kidneys Hearts and Lives workshop

Having a fabulous Bluesky day in Japan! Trip to Minamata with team #Alport & family @moumitabarua.bsky.social @jeffminerphd.bsky.social @alportuk.bsky.social

It’s always a special evening when having a yakitori dinner with former Japanese postdocs in Tokyo. @washunephrology.bsky.social

Please tune in!

Alport syndrome is an inherited disorder characterized by kidney disease, sensorineural hearing loss, and ocular abnormalities. In this review, the authors provide an overview of how genotype-phenotype-mechanisms are key for a precision medicine-based approach in the future. bit.ly/JASN0647 #ASNJASN

Greetings from thankfully in-progress DDK-G study section, reviewing KUH Fellowship grants. Such dedicated reviewers, especially one who joins us from Hawaii, where it is 2 am.

🎉Today we celebrate International Day of Women and Girls in Science! We are extremely #PROUD of all the #WomenInASMB, their accomplishments, both past and present, and we are excited to see what the future holds! #WomenInSTEM #ECMatrixIsEverywhere #ScienceNoBoundaries

This seems worth checking out!

I am registered! Are you?

You'll be hearing from me on one of these dates. More to come! @washunephrology.bsky.social

Regarding my February NIH Study Section meeting, I received this email overnight: Dear Dr. Miner, Our meeting will be held on Feb. 12 as planned. I am grateful for the lack of uncertainty, as my reviews are due shortly after the Super Bowl ends. My fingers are crossed.

Any anecdotal info on NIH Study Section meetings this week?

In January 2025 CJASN @asnpublications.bsky.social : "78% of monogenic causes of kidney disease identified were due to mutations in 1 of 9 genes, encompassing 4 subtypes of CKD." PKD1, PKD2, COL4A3, COL4A4, COL4A5, APOL1, MUC1, UMOD.(3 of my favorites included) pubmed.ncbi.nlm.nih.gov/39792540/

This month is American #HeartMonth! 🫀 Join ASN in celebrating and raising awareness. Heart disease, hypertension, and kidney disease are all connected—an issue with one can impact the others. Keep your heart and kidneys healthy! Learn more @americanheart.bsky.social

Invest in yourself with ASN! 🌟 Access the latest research, valuable resources, and career opportunities while connecting with a global network of nephrology. Join by February 1 and save $20—take advantage of this offer today! 💥http://asn.kdny.info/eF4s50UL1ox

First ASN Council call of 2025. Honored to be working with this incredible group of leaders! @drdeidracrews.bsky.social

The proof is in the data: academic.oup.com/ndt/advance-... Cysts are not caused by Alport syndrome, though patients with Alport syndrome can have cysts.

To add insult to potential injury, this morning on The Today Show, @nbcnews.com showed the city of Brentwood, CA in the San Francisco Bay Area as threatened by fire, rather than the neighborhood of Brentwood in LA. Is this because of AI or LoI (Lack of Intelligence)?

Actually, I joined Twitter 12 years ago. Not X. It’s been a good run. Time to (gradually) move on.

Such an enjoyable evening!

Best wishes for the festive season from the Alport UK team! Thank you to all who volunteer, fundraise and offer their support throughout the year. Happy holidays everyone!

Happy Holidays from the Miner Lab et al.!

Sharing my final Kidney News update as President @asnkidney.bsky.social www.kidneynews.org/view/journal...

Genotype-First Analysis in an Unselected Health System–Based Population and Phenotypic Severity of COL4A5 Variants. tl;dr The spectrum of kidney disease in those with COL4A5 variants is broad and under diagnosed. journals.lww.com/jasn/abstrac...