Johannes Betge (@drbetge.bsky.social)

Combined MEK and PARP inhibition enhances radiation response in rectal cancer Xiao et al. use patient-derived rectal cancer organoids to identify that MEK inhibitors enhance radiation sensitivity by downregulating the DNA damage response protein RAD51. They find synergy with combined PARP inhibition in different preclinical models, thereby offering a promising regimen and potential future alternative to conventional chemoradiation in locally advanced rectal cancer. http://dlvr.it/TMcFnc