Sophie Lanciano (@sophielanciano.bsky.social)

#NotOnlyParasites! 2 Cell papers by @edchuong.bsky.social lab & Amigorena lab demonstrate that transposable elements #TEs can exonize giving rise to functional (often shorter) proteins with distinct functions: eg a decoy short IFNAR2 that inhibits #interferon signaling! www.cell.com/cell/fulltex...

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Transposable element exonization generates a reservoir of evolving and functional protein isoforms Transposable element exonization by unannotated splicing events produces stable protein isoforms with acquired functions that are subject to evolutionary selection. https://www.cell.com/cell/fulltext/S0092-8674(24)01328-X