@andreichabes.bsky.social
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Department of Medical Biochemistry and Biophysics (MBB)
2 months ago
🚨 New research drop! A new study from
@andreichabes.bsky.social
’ group (with Tomomi Tsubouchi + Erik Johansson) overturns a long-standing assumption about how nucleosides speed up DNA replication. Paper in
@narjournal.bsky.social
:
doi.org/10.1093/nar/...
Huge congrats to Praveen Pandey et al.! 🎉
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Decoding nucleoside supplementation: how thymidine outperforms ribonucleosides in accelerating mammalian replication forks
Abstract. Disruptions in deoxynucleoside triphosphate (dNTP) supply impair DNA replication and lead to genomic instability. While exogenous ribonucleosides
https://doi.org/10.1093/nar/gkaf1035
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New research from our lab on mitochondrial DNA stability RRM2B is essential for making dNTPs in non-dividing cells and its loss causes mt DNA depletion syndromes. Surprisingly, we found that RRM2B deficiency leads to a drop in dATP and dGTP.
www.pnas.org/doi/10.1073/...
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PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
https://www.pnas.org/doi/10.1073/pnas.2503531122
10 months ago
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