Abid Hussain
@amh10.bsky.social
📤 953
📥 1247
📝 289
Medical Microbiologist & Clinical Services Director @UKHSA BPHL. All posts my own.
#QI
#ClinGov
Resolving a NICU outbreak of meticillin-resistant Staphylococcus aureus to the single-nucleotide variant level using Oxford Nanopore simplex reads and HERRO error correction
www.journalofhospitalinfection.com/article/S019...
@alanmcn1.bsky.social
@wvschaik.bsky.social
@jessicamablair.bsky.social
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Resolving a neonatal intensive care unit outbreak of meticillin-resistant Staphylococcus aureus to the single-nucleotide variant level using Oxford Nanopore simplex reads and HERRO error correction
Our laboratory began prospective genomic surveillance for healthcare-associated organisms in 2022 using Oxford Nanopore Technologies (ONT) as a standalone platform. While effective for early outbreak ...
https://www.journalofhospitalinfection.com/article/S0195-6701%2825%2900177-X/fulltext
23 days ago
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Advancements in urinary tract infections: understanding, prevention, diagnosis, and treatment
doi.org/10.1177/2049...
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Advancements in urinary tract infections: understanding, prevention, diagnosis, and treatment - Bhaskar K. Somani, 2025
https://doi.org/10.1177/20499361251376457
23 days ago
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Empiric antibiotics for moderate-severe community-Acquired Pneumonia: We ought to serve patients better! - More studies needed
www.clinicalmicrobiologyandinfection.org/article/S119...
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Empiric antibiotics for moderate-severe community-Acquired Pneumonia: We ought to serve patients better!
Each day thousands of patients are hospitalized worldwide with Community-Acquired Pneumonia (CAP), either radiologically confirmed or presumed based on clinical symptoms only, and each day physicians ...
https://www.clinicalmicrobiologyandinfection.org/article/S1198-743X%2825%2900427-6/fulltext
23 days ago
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reposted by
Abid Hussain
Alan McNally
23 days ago
Read this properly now and it really is a staggeringly beautiful study. And super important. Opens a new avenue of research I reckon. One of my papers of the year.
add a skeleton here at some point
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Cardiac Manifestations of Mycoplasma pneumoniae Infections: A Cohort Study 2007–2024 url:
academic.oup.com/cid/article/...
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Cardiac Manifestations of Mycoplasma pneumoniae Infections: A Cohort Study 2007–2024
A 17-year cohort shows higher incidence of cardiac involvement than previously reported in patients admitted with Mycoplasma pneumoniae infections that may
https://academic.oup.com/cid/article/doi/10.1093/cid/ciaf453/8244960
23 days ago
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Teicoplanin total trough concentration and adverse effects in patients with hypoalbuminemia - Journal of Infection and Chemotherapy
www.jiac-j.com/article/S134...
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Teicoplanin total trough concentration and adverse effects in patients with hypoalbuminemia
The association between Teicoplanin (TEIC) total trough concentration (Cmin) and adverse effects (hepatotoxicity, nephrotoxicity, and thrombocytopenia) in patients with hypoalbuminemia remains poorly ...
https://www.jiac-j.com/article/S1341-321X%2825%2900204-1/fulltext
23 days ago
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The international and intercontinental spread and expansion of antimicrobial-resistant Salmonella Typhi: a genomic epidemiology study - The Lancet Microbe
www.thelancet.com/journals/lan...
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The international and intercontinental spread and expansion of antimicrobial-resistant Salmonella Typhi: a genomic epidemiology study
Independent acquisition of plasmids and homoplastic mutations conferring antimicrobial resistance have occurred repeatedly in multiple lineages of S Typhi, predominantly arising in south Asia before s...
https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247%2822%2900093-3/fulltext
3 months ago
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www.nature.com/articles/s41...
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Brief antibiotic use drives human gut bacteria towards low-cost resistance - Nature
Brief ciprofloxacin exposure in humans drives antibiotic resistance evolution in gut bacteria through selective sweeps, particularly involving DNA gyrase mutations, which persist long after exposure a...
https://www.nature.com/articles/s41586-025-08781-x
5 months ago
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reposted by
Abid Hussain
Penta Foundation
5 months ago
To tackle antibiotic resistance (#AMR) in newborns, especially premature babies in
#NICUs
, researchers explored the best trial design for studying
#IPC
. See what this simulation study, based on
#NeoIPC
data and presented at
#ESCMIDGlobal
, suggests 👇 View poster:
neoipc.org/wp-content/u...
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Using R coding
#ESCMID2025
6 months ago
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Using R!
#ESCMID2025
6 months ago
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Candida diagnostics in endovascular infections. Is
@brukercorporation.bsky.social
#MALDI
better for Candida pararugosa?
#ESCMID2025
6 months ago
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reposted by
Abid Hussain
ESCMID
6 months ago
Get ready! The Clinical Grand Round is about to begin in Hall 1. Six renowned experts take on seven tough
#infectiousdisease
cases. Don’t miss the excitement and insights as they solve complex clinical challenges at
#ESCMIDGlobal
2025!
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reposted by
Abid Hussain
Society of Infectious Diseases Pharmacists - SIDP
6 months ago
Don't miss this one from Dr. Noor Zaidan and team as they provide insight on optimal recurrent Cdiff infection at
#ESCMIDGlobal
2025! 🦠 Key point: Sequential use of fidaxomicin and vancomycin did not significantly impact CDI recurrence rate within 8 weeks at UTMB Health.
@rachelbpharmd.bsky.social
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Abid Hussain
Miranda So PharmD MPH (Epidemiology)
6 months ago
I’ve long admired the approach of
#ECIL
on febrile neutropenia in hemato-oncology/HSCT patients which informed our local guidelines. So grateful to hear Prof Averbuch re: updates to ECIL FN GL 🙏 De-escalate early beneficial Know colonization hx and local epi
#ESCMIDGlobal
#antimicrobialstewardship
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Always talk of the PO PKPD
#ESCMID2025
6 months ago
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Other factors
#ESCMID2025
6 months ago
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Why is this not happening
#ESCMID2025
6 months ago
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Lack of uptake
#ESCMID2025
6 months ago
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Effect of oral Rx
#ESCMID2025
6 months ago
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Post POET oral Rx in IE
#ESCMID2025
6 months ago
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More oral Rx for IE
#ESCMID2025
6 months ago
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Oral Rx for IE
#ESCMID2025
6 months ago
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More Rx
#ESCMID2025
6 months ago
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Beta lactams
#ESCMID2025
Streps and Staphs
6 months ago
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Treatment
#ESCMID2025
innoculum effect
6 months ago
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Modified Dukes
#ESCMID2025
6 months ago
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Blood cultures and their use in IE.
#ESCMID2025
6 months ago
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Enterococcal cover
#ESCMID2025
6 months ago
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IE prophylaxis
#ESCMID2025
, great to see delabelling.
6 months ago
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reposted by
Abid Hussain
Brad Spellberg
6 months ago
One does need to match published data to bug. Amoxicillin is perfectly appropriate for strep. Levels achieved well above strep target attainment. RCT data support for strep endocarditis. MICs for Enterobacterales are higher—cannot extrapolate to them.
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De-escalation in invasive cases
#ESCMID2025
6 months ago
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reposted by
Abid Hussain
Michael Marks
6 months ago
Interesting data Barista showing diversity in S. aureus isolates from sterile sites. Some evidence isolates become enriched for mutations over time. Wonder if really evolution over time or if samples from deeper sites would differ at baseline from those in blood?
@steventong.bsky.social
#ESCMID2025
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This is a sensible bar for IVOS
#ESCMID2025
6 months ago
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reposted by
Abid Hussain
Alexander V. Veselov 😷🎮
6 months ago
Primary antifungal prophylaxis in hematological malignancies. Updated clinical practice guidelines by the European Conference on Infections in Leukemia (ECIL). Livio Pagano, et al. Leukemia, 2025.
www.nature.com/articles/s41...
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Primary antifungal prophylaxis in hematological malignancies. Updated clinical practice guidelines by the European Conference on Infections in Leukemia (ECIL) - Leukemia
Leukemia - Primary antifungal prophylaxis in hematological malignancies. Updated clinical practice guidelines by the European Conference on Infections in Leukemia (ECIL)
https://www.nature.com/articles/s41375-025-02586-7
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Endocarditis?
#ESCMID2025
6 months ago
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@bradspellberg.bsky.social
is busting myths left and right
#ESCMID2025
6 months ago
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What is the outcome data?
#ESCMID2025
6 months ago
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PAER AmpC
#ESCMID2025
6 months ago
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AmpC in PAER, what should we do?
#ESCMID2025
6 months ago
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Summary of AmpC Rx
#ESCMID2025
6 months ago
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Hold newer agents back
#ESCMID2025
6 months ago
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Where is the data for AmpC Rx?
#ESCMID2025
cont TAZ if source controlled and pt getting better?
6 months ago
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Now the AmpC Rx
#ESCMID2025
6 months ago
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#AmpC
#ESCMID2025
6 months ago
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PAER phenotypes
#ESCMID2025
6 months ago
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More AmpC
#ESCMID2025
6 months ago
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