Abid Hussain
@amh10.bsky.social
📤 975
📥 1247
📝 305
Medical Microbiologist & Clinical Services Director @UKHSA BPHL. All posts my own.
#QI
#ClinGov
Candida UTI? The only azole available (if sensitive) is fluconazole. Why?
about 12 hours ago
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Pearl of the week: Compare and contrast DILI in flucloxacillin vs cefazolin. They key thing is that a *single* dose of cefazolin can cause LFT derrangment.
about 12 hours ago
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reposted by
Abid Hussain
Antibiotic Steward 🅱️C🆔🅿️🌟
21 days ago
🆕💥🟢LIPS RCT Protocol: LInezolid Plus Standard of care 12 Swiss hospitals Linezolid in addition to standard antibiotic treatment for Staphylococcus aureus bacteraemia More combo /SA Bactremia Clinda failed in SNAP,will LZD make it? More combo from SNAP
#idsky
bmjopen.bmj.com/content/16/4...
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The international and intercontinental spread and expansion of antimicrobial-resistant Salmonella Typhi: a genomic epidemiology study - The Lancet Microbe
www.thelancet.com/journals/lan...
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The international and intercontinental spread and expansion of antimicrobial-resistant Salmonella Typhi: a genomic epidemiology study
Independent acquisition of plasmids and homoplastic mutations conferring antimicrobial resistance have occurred repeatedly in multiple lineages of S Typhi, predominantly arising in south Asia before s...
https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247%2822%2900093-3/fulltext
2 months ago
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Checkout this article I found at PLOS:
dx.plos.org/10.1371/jour...
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Ionizing Radiation Changes the Electronic Properties of Melanin and Enhances the Growth of Melanized Fungi
BackgroundMelanin pigments are ubiquitous in nature. Melanized microorganisms are often the dominating species in certain extreme environments, such as soils contaminated with radionuclides, suggestin...
https://dx.plos.org/10.1371/journal.pone.0000457
3 months ago
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Genomic and physiological signatures of adaptation in pathogenic fungi
doi.org/10.1038/s414...
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Genomic and physiological signatures of adaptation in pathogenic fungi - Nature Communications
Emerging fungal pathogens have detrimental impacts on crops, animals, and humans, however little is known about their transition to a pathogenic lifestyle. This study demonstrates that the transition ...
https://doi.org/10.1038/s41467-026-68330-6
3 months ago
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Enterococcal cytolysin, add to pathogenicity: Synergistic interactions between Candida albicans and Enterococcus faecalis promote toxin-dependent host cell damage | PNAS
share.google/fiK7cIw373xC...
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Synergistic interactions between Candida albicans and Enterococcus faecalis promote toxin-dependent host cell damage | PNAS
The fungus Candida albicans and the Gram-positive bacterium Enterococcus faecalis share mucosal niches in the human body. As opportunistic pathogen...
https://share.google/fiK7cIw373xCpLupk
3 months ago
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An interesting role for faecal transplants
rdcu.be/e1JKV
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Fecal microbiota transplantation plus pembrolizumab and axitinib in metastatic renal cell carcinoma: the randomized phase 2 TACITO trial
Nature Medicine - In a double-blind, placebo-controlled phase 2 trial in patients with metastatic renal cell carcinoma treated with anti-PD-1 plus a VEGFR tyrosine kinase inhibitor, donor fecal...
https://rdcu.be/e1JKV
3 months ago
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Bradyzoite subtypes rule the crossroads of Toxoplasma development
rdcu.be/e1zCI
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Bradyzoite subtypes rule the crossroads of Toxoplasma development
Nature Communications - The authors investigate the heterogeneity of Toxoplasma bradyzoites prior to recrudescence. Tissue cysts from infected mice harbor multiple bradyzoite subtypes with distinct...
https://rdcu.be/e1zCI
3 months ago
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reposted by
Abid Hussain
ESCMID
4 months ago
This online course presents the current knowledge on PK/PD of common antibiotics & antivirals, setting clinical breakpoints, individualised dosing & TDM. Innovative approaches for drug development also highlighted. More:
https://ow.ly/mszr50XXS9H
⏰Register by 09 March 2026!
#IDSky
#clinmicro
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Antibiotic Therapy for Uncomplicated Acute Appendicitis:
jamanetwork.com/journals/jam...
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Antibiotic Therapy for Uncomplicated Acute Appendicitis
This observational follow-up of patients in the Appendicitis Acuta multicenter randomized clinical trial conducted in Finland assesses the 10-year appendicitis recurrence and appendectomy rate in adul...
https://jamanetwork.com/journals/jama/fullarticle/2844116?utm_source=bluesky&utm_campaign=content-shareicons&utm_content=article_engagement&utm_medium=social&utm_term=012126
4 months ago
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www.linkedin.com/posts/uk-hea...
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ESPAUR Abstracts Published: Perspectives on a valuable resource for tackling antimicrobial resistance | UK Health Security Agency
UKHSA's English Surveillance Programme for Antimicrobial Utilisation and Resistance (ESPAUR) abstracts are now available in a dedicated journal supplement, making this vital data more accessible to re...
https://www.linkedin.com/posts/uk-health-security-agency_ukhsas-english-surveillance-programme-for-activity-7418968492722282496-NGiE?utm_source=share&utm_medium=member_android&rcm=ACoAABHmmiQBJmxFv0JcVLBgc-ThpurUovAXrb8
4 months ago
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Albumin orchestrates a natural host defence mechanism against mucormycosis | Nature
share.google/gKuxL49O8Fsj...
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Albumin orchestrates a natural host defence mechanism against mucormycosis - Nature
Albumin selectively inhibits Mucorales growth through the release of bound free fatty acids.
https://share.google/gKuxL49O8FsjdyXx2
4 months ago
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The hidden link between cefiderocol resistance and increased virulence in Klebsiella pneumoniae: Insights from a TraDIS-based investigation - Clinical Microbiology and Infection
www.clinicalmicrobiologyandinfection.org/article/S119...
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The hidden link between cefiderocol resistance and increased virulence in Klebsiella pneumoniae: Insights from a TraDIS-based investigation
The emergence of extensively drug-resistant Enterobacterales, particularly carbapenemase-producing Klebsiella pneumoniae, poses a serious global health threat. Cefiderocol (FDC), a sideromycin antibio...
https://www.clinicalmicrobiologyandinfection.org/article/S1198-743X%2825%2900619-6/fulltext
5 months ago
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The songs I listened to most this year.
#SpotifyWrapped
www.spotify.com/wrapped-shar...
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My Top Songs of 2025
Spotify
https://www.spotify.com/wrapped-share/2c4e15af593a43d389ee46d53d933ba9?si=ah_wKQryRdyo0AweIIURCA&feature=wrapped&destination=datastories&lang=en
5 months ago
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Disenchanted took my top spot this year. More in my
#SpotifyWrapped
www.spotify.com/wrapped-shar...
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My Top Song of 2025
Spotify
https://www.spotify.com/wrapped-share/2034dc5b1a0c4324918774a40b4450ef?si=XzVTpEdSRQyTpIYPPo_uXw&feature=wrapped&destination=datastories&lang=en
5 months ago
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reposted by
Abid Hussain
JAC-AMR
5 months ago
In high-risk febrile neutropenic patients, an AMS bundle safely reduced broad-spectrum antibiotic use, shifting from MEM to CAZ and shortening treatment duration A meaningful step forward in
#AntimicrobialStewardship
in high-risk populations
doi.org/10.1093/jaca...
#JACAMRNews
#IDSky
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Impact of an antimicrobial stewardship bundle on the outcome of high-risk neutropenic patients with fever: a pre-post study
AbstractBackground. Rapid antibiotic initiation is essential for managing potential infections following chemotherapy-induced neutropenia. However, excessi
https://doi.org/10.1093/jacamr/dlaf191
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The key question is, where does Emblaveo fit when chosing empirical therapy?https://link.springer.com/article/10.1007/s40265-025-02258-x
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Aztreonam-Avibactam: A Review in the Treatment of Serious Bacterial Infections Caused by Aerobic Gram-Negative Organisms - Drugs
Aztreonam-avibactam (Emblaveo™), a fixed-dose combination of the monobactam antibacterial agent aztreonam and the broad-spectrum β-lactamase inhibitor avibactam, has been developed as a treatment, adm...
https://link.springer.com/article/10.1007/s40265-025-02258-x
6 months ago
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My thoughts on AMS and where we are heading:
www.linkedin.com/pulse/stewar...
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Stewardship 2.0: Harnessing Data, Tech, and Teamwork to Save Antibiotics
When we think about the rise of antibiotic-resistant superbugs, our minds typically go to one place: the unwell patient. The prevailing wisdom is that antimicrobial resistance (AMR) is a direct conseq...
https://www.linkedin.com/pulse/stewardship-20-harnessing-data-tech-teamwork-save-abid-hussain-2ryqe
7 months ago
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Resolving a NICU outbreak of meticillin-resistant Staphylococcus aureus to the single-nucleotide variant level using Oxford Nanopore simplex reads and HERRO error correction
www.journalofhospitalinfection.com/article/S019...
@alanmcn1.bsky.social
@wvschaik.bsky.social
@jessicamablair.bsky.social
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Resolving a neonatal intensive care unit outbreak of meticillin-resistant Staphylococcus aureus to the single-nucleotide variant level using Oxford Nanopore simplex reads and HERRO error correction
Our laboratory began prospective genomic surveillance for healthcare-associated organisms in 2022 using Oxford Nanopore Technologies (ONT) as a standalone platform. While effective for early outbreak ...
https://www.journalofhospitalinfection.com/article/S0195-6701%2825%2900177-X/fulltext
8 months ago
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Advancements in urinary tract infections: understanding, prevention, diagnosis, and treatment
doi.org/10.1177/2049...
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Advancements in urinary tract infections: understanding, prevention, diagnosis, and treatment - Bhaskar K. Somani, 2025
https://doi.org/10.1177/20499361251376457
8 months ago
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Empiric antibiotics for moderate-severe community-Acquired Pneumonia: We ought to serve patients better! - More studies needed
www.clinicalmicrobiologyandinfection.org/article/S119...
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Empiric antibiotics for moderate-severe community-Acquired Pneumonia: We ought to serve patients better!
Each day thousands of patients are hospitalized worldwide with Community-Acquired Pneumonia (CAP), either radiologically confirmed or presumed based on clinical symptoms only, and each day physicians ...
https://www.clinicalmicrobiologyandinfection.org/article/S1198-743X%2825%2900427-6/fulltext
8 months ago
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reposted by
Abid Hussain
Alan McNally
8 months ago
Read this properly now and it really is a staggeringly beautiful study. And super important. Opens a new avenue of research I reckon. One of my papers of the year.
add a skeleton here at some point
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Cardiac Manifestations of Mycoplasma pneumoniae Infections: A Cohort Study 2007–2024 url:
academic.oup.com/cid/article/...
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Cardiac Manifestations of Mycoplasma pneumoniae Infections: A Cohort Study 2007–2024
A 17-year cohort shows higher incidence of cardiac involvement than previously reported in patients admitted with Mycoplasma pneumoniae infections that may
https://academic.oup.com/cid/article/doi/10.1093/cid/ciaf453/8244960
8 months ago
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Teicoplanin total trough concentration and adverse effects in patients with hypoalbuminemia - Journal of Infection and Chemotherapy
www.jiac-j.com/article/S134...
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Teicoplanin total trough concentration and adverse effects in patients with hypoalbuminemia
The association between Teicoplanin (TEIC) total trough concentration (Cmin) and adverse effects (hepatotoxicity, nephrotoxicity, and thrombocytopenia) in patients with hypoalbuminemia remains poorly ...
https://www.jiac-j.com/article/S1341-321X%2825%2900204-1/fulltext
8 months ago
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The international and intercontinental spread and expansion of antimicrobial-resistant Salmonella Typhi: a genomic epidemiology study - The Lancet Microbe
www.thelancet.com/journals/lan...
loading . . .
The international and intercontinental spread and expansion of antimicrobial-resistant Salmonella Typhi: a genomic epidemiology study
Independent acquisition of plasmids and homoplastic mutations conferring antimicrobial resistance have occurred repeatedly in multiple lineages of S Typhi, predominantly arising in south Asia before s...
https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247%2822%2900093-3/fulltext
10 months ago
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www.nature.com/articles/s41...
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Brief antibiotic use drives human gut bacteria towards low-cost resistance - Nature
Brief ciprofloxacin exposure in humans drives antibiotic resistance evolution in gut bacteria through selective sweeps, particularly involving DNA gyrase mutations, which persist long after exposure a...
https://www.nature.com/articles/s41586-025-08781-x
about 1 year ago
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reposted by
Abid Hussain
Penta - Child Health Research
about 1 year ago
To tackle antibiotic resistance (#AMR) in newborns, especially premature babies in
#NICUs
, researchers explored the best trial design for studying
#IPC
. See what this simulation study, based on
#NeoIPC
data and presented at
#ESCMIDGlobal
, suggests 👇 View poster:
neoipc.org/wp-content/u...
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Using R coding
#ESCMID2025
about 1 year ago
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Using R!
#ESCMID2025
about 1 year ago
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Candida diagnostics in endovascular infections. Is
@brukercorporation.bsky.social
#MALDI
better for Candida pararugosa?
#ESCMID2025
about 1 year ago
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reposted by
Abid Hussain
ESCMID
about 1 year ago
Get ready! The Clinical Grand Round is about to begin in Hall 1. Six renowned experts take on seven tough
#infectiousdisease
cases. Don’t miss the excitement and insights as they solve complex clinical challenges at
#ESCMIDGlobal
2025!
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reposted by
Abid Hussain
Society of Infectious Diseases Pharmacists - SIDP
about 1 year ago
Don't miss this one from Dr. Noor Zaidan and team as they provide insight on optimal recurrent Cdiff infection at
#ESCMIDGlobal
2025! 🦠 Key point: Sequential use of fidaxomicin and vancomycin did not significantly impact CDI recurrence rate within 8 weeks at UTMB Health.
@rachelbpharmd.bsky.social
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reposted by
Abid Hussain
Miranda So PharmD MPH (Epidemiology)
about 1 year ago
I’ve long admired the approach of
#ECIL
on febrile neutropenia in hemato-oncology/HSCT patients which informed our local guidelines. So grateful to hear Prof Averbuch re: updates to ECIL FN GL 🙏 De-escalate early beneficial Know colonization hx and local epi
#ESCMIDGlobal
#antimicrobialstewardship
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Always talk of the PO PKPD
#ESCMID2025
about 1 year ago
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Other factors
#ESCMID2025
about 1 year ago
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Why is this not happening
#ESCMID2025
about 1 year ago
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Lack of uptake
#ESCMID2025
about 1 year ago
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Effect of oral Rx
#ESCMID2025
about 1 year ago
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Post POET oral Rx in IE
#ESCMID2025
about 1 year ago
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More oral Rx for IE
#ESCMID2025
about 1 year ago
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Oral Rx for IE
#ESCMID2025
about 1 year ago
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More Rx
#ESCMID2025
about 1 year ago
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Beta lactams
#ESCMID2025
Streps and Staphs
about 1 year ago
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Treatment
#ESCMID2025
innoculum effect
about 1 year ago
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Modified Dukes
#ESCMID2025
about 1 year ago
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Blood cultures and their use in IE.
#ESCMID2025
about 1 year ago
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Enterococcal cover
#ESCMID2025
about 1 year ago
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IE prophylaxis
#ESCMID2025
, great to see delabelling.
about 1 year ago
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