Kez Cleal
@kezc.bsky.social
๐ค 751
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Lecturer in cancer bioinformatics at Cardiff University.
https://github.com/kcleal
Tagging for the
#GeroSky
community - would welcome any discussion
add a skeleton here at some point
11 days ago
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Happy to share a new preprint exploring the idea that multicellular coordination may itself be a fundamental constraint in ageing, and asking how stochastic cellular damage is translated into tissue-level decline ๐งต
www.preprints.org/manuscript/2...
12 days ago
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reposted by
Kez Cleal
Anna Poetsch
8 months ago
We are happy to present a new paper on gastric tumour evolution in response to peri-operative chemotherapy.
www.biorxiv.org/content/10.1...
๐งต 1/6
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Tumor clone dynamics in gastro-esophageal cancer organoids reveal a non-genetic memory of neoadjuvant chemotherapy via downregulation of NFฮบB signaling
Adenocarcinomas of the gastroesophageal junction exhibit genetic and non-genetic heterogeneity that impact clinical outcomes, though the underlying mechanisms behind drug resistance remain poorly unde...
https://www.biorxiv.org/content/10.1101/2025.07.29.667467v1
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reposted by
Kez Cleal
David A Knowles
9 months ago
New work from the lab trying to wrap our heads around the massive complexity of the human transcriptome revealed by long-read RNA-seq! Fun collab with Gloria Sheynkman.
www.biorxiv.org/content/10.1...
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Perplexity as a Metric for Isoform Diversity in the Human Transcriptome
Long-read sequencing (LRS) has revealed a far greater diversity of RNA isoforms than earlier technologies, increasing the critical need to determine which, and how many, isoforms per gene are biologic...
https://www.biorxiv.org/content/10.1101/2025.07.02.662769v1
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๐จ Our GW paper is out in Nature Methods!๐ฅฒ GW is a fast genomics browser (up to 100x faster!)
github.com/kcleal/gw
Also, just released a Python interface for GW
github.com/kcleal/gwplot
๐
nature.com/articles/s4159โฆ
#Genomics
c
#Bioinformatics
cs
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GitHub - kcleal/gw: Genome browser and variant annotation
Genome browser and variant annotation. Contribute to kcleal/gw development by creating an account on GitHub.
https://github.com/kcleal/gw
9 months ago
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A really useful resource
add a skeleton here at some point
12 months ago
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@adbeggs.bsky.social
Hi Andrew. Fantastic talk today at the WCRC conference! It was very inspiring ๐
about 1 year ago
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๐งฌ๐ฅ๏ธ Just released Dysgu v1.8 which now supports phasing of structural variants when using long reads. Makes SV calling much more sensitive - see PacBio benchmark ๐
github.com/kcleal/SV_Be...
dysgu repo
github.com/kcleal/dysgu...
about 1 year ago
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๐งฌ๐ฅ๏ธ Sharing an update to my SV benchmark repo. More callers have been added for the CMRG/GIAB benchmarks.
github.com/kcleal/SV_Be...
. Also now uses
#Nextflow
and tests the newest
#PacBio
Vega data, along with
#ONT
kit14. Results are on the GitHub page ๐
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GitHub - kcleal/SV_Benchmark_CMRG_GIAB: Structural variant benchmark of challenging medically relevant genes
Structural variant benchmark of challenging medically relevant genes - kcleal/SV_Benchmark_CMRG_GIAB
https://github.com/kcleal/SV_Benchmark_CMRG_GIAB
over 1 year ago
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Hi all. Just released a fast library (C++/Rust/Python) for performing interval intersections. Uses a novel superset-index that tends to be faster than current libs, and also has a SIMD accelerated counting algorithm ๐
github.com/kcleal/super...
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GitHub - kcleal/superintervals: Fast interval intersection library
Fast interval intersection library. Contribute to kcleal/superintervals development by creating an account on GitHub.
https://github.com/kcleal/superintervals
over 1 year ago
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reposted by
Kez Cleal
Rob Patro
over 1 year ago
I made a starter pack for algorithmic genomics. It's certainly incomplete, but already has a ton of awesome peeps. Let me know if you know people I should add (with a focus on algorithms and data structures in genomics)
go.bsky.app/TRWCnZs
add a skeleton here at some point
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BioNumpy looks really good, looking forward to giving this a try
www.nature.com/articles/s41...
over 1 year ago
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reposted by
Kez Cleal
Stephen Turner
over 1 year ago
I created a genomics+bioinformatics starter pack. If I left you off, *please* reply and I'll add you!
go.bsky.app/B5YYBfq
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Genomics+Bioinformatics Starter Pack ๐งฌ๐ฅ๏ธ
Join the conversation
https://go.bsky.app/B5YYBfq
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Hello world! This looks promising
over 2 years ago
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you reached the end!!
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