IgG4-related disease and other fibro-inflammatory conditions www.nature.com/articles/s41...

Mechanisms of prothrombotic cell activation by anti-β2GPI IgG. The diagram highlights the receptors most commonly linked to cell activation by β2GPI/anti-β2GPI IgG surface complexes, as well as some effectors known to be downstream of that activation #Rheumsky #Immunosky

Non-Criteria Obstetric Antiphospholipid Syndrome: Myth or Reality? NC-OAPS: heterogeneous condition and ambiguously described in literature #APS #OAPS #Pregnancy #autoimmune

Today is International Vasculitis Day! Take a look at some of our articles on vasculitis: Evidence-Based Guideline for the diagnosis and management of eosinophilic granulomatosis with polyangiitis bit.ly/4kjASRj The new look of classification criteria for systemic vasculitis bit.ly/3GXJLlc

Behçet syndrome 🩸systemic #vasculitis, affects vessels of all calibers 🩺 venous #thrombosis with arterial #aneurysms, inflammatory parenchymal brain involvement, posterior #uveitis with retinal vasculitis, bipolar #ulcers and erythema nodosum ⁉️ controversy: pathergy test or HLA-B*51 in diagnosis

Arterial and venous thrombosis in systemic and monogenic vasculitis ⚠️ Be aware for early diagnosis‼️ 🧬 Genetic testing vital—variable penetrance! Early strokes hint at diagnosis. #vasculitis #thrombosis #monogenic #stroke #skin www.nature.com/articles/s41...

🚨2024 American College of Rheumatology (ACR) Guideline for the Screening, Treatment, and Management of Lupus Nephritis #Lupus #Nephritis #Guideline #Treatment #SLE assets.contentstack.io/v3/assets/bl...

Consensus nomenclature and abbreviation for anti-synthetase syndrome: an IMACS project 🚩lack of uniform terminology and abbreviations = challenges in research and clinical practice 🏳️anti-synthetase syndrome and ASyS should be adopted as the standard nomenclature academic.oup.com/rheumatology...

Remnant cholesterol predicts risk of recurrent thrombosis beyond LDL‑cholesterol in patients with antiphospholipid syndrome 🟠RC ➡️ increased risk of trombosis 🟠RC marker for thrombotic risk❓ 🟠potential target for therapeutic intervention. bmcmedicine.biomedcentral.com/counter/pdf/...

EULAR recommendations for use of antirheumatic drugs in reproduction, pregnancy, and lactation: 2024 update 🤰🏽👩🏽‍🍼 ard.eular.org/action/showP...

Consensus Recommendations for the Management of Neurosarcoidosis www.neurology.org/doi/10.1212/...

Recommendations for the use of DMARDs in pregnancy and reproductive health for patients with rheumatic disease: A scoping review acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

To B or Not to B — the Role of B-Cell Depletion in Lupus Nephritis www.nejm.org/doi/full/10....

IL-10 in Systemic Lupus Erythematosus: Balancing Immunoregulation and Autoimmunity 🔑involved in inflammatory and immune processes in SLE. 🔹IL-10 did not correlate with disease activity, organ in- volvement, or treatment response. www.mdpi.com/1422-0067/26...

A proposed clinical tool to identify high-risk patients for #monogenic #lupus: a pilot study 💡<5 years 💡cosanguinity 💡Family #SLE 💡elevated ANA 💡pancytopenia 💡cutaneus lesions 💡Low C1q 💡Recurrent infections 💡Failure to thrive www.clinexprheumatol.org/abstract.asp...

Therapeutic approaches for #SAPHO syndrome from the perspective of pathogenesis: a review of the literature 🔸Autoinflammatory 🔸cutaneous & osteoarticular 🔹ATB, tonsillectomy 🔹DMARDs 🔹Bisphosphonates www.frontiersin.org/journals/imm...

British Association of Dermatologists and British Society for Rheumatology living guideline for managing people with Behçets 2024 👇🏼👀 academic.oup.com/bjd/article/...

Prognostic insights from symptom clustering analysis in systemic lupus erythematosus 1️⃣ Articular/mucocutaneous ➡️better survival 2️⃣Severe phenotype with renal involvement ➡️ poor prognosis 3️⃣Mixed connective tissue disease-like features with anti-U1-RNP antibodies rmdopen.bmj.com/content/11/2...

Urine Protein Tests in Systemic Lupus Erythematosus: What Do They Mean? #SLE #Lupus #LN www.jrheum.org/content/jrhe...

Autoinflammatory Diseases: A Revision www.jrheum.org/content/51/9...

Antiphospholipid syndrome in pregnancy: a comprehensive literature review 🤍 bmcpregnancychildbirth.biomedcentral.com/articles/10....

A Phase 3 Trial of Upadacitinib for Giant-Cell Arteritis 📌In patients with giant-cell arteritis, upadacitinib at a dose of 15 mg — but not 7.5 mg — with a 26-week glucocorticoid taper showed efficacy superior to that of placebo with a 52-week glucocorticoid taper www.nejm.org/doi/full/10....

Comparative Efficacy of Immunosuppressive Therapies in the Treatment of Diffuse Cutaneous Systemic Sclerosis 🔸MMF in dcSSc and show benefit especially in early-stage disease. 🔸High-risk ab for lung fibrosis ➡️ suitable for MMF treatment. acrjournals.onlinelibrary.wiley.com/doi/full/10....

Thoracic Manifestations of ANCA-associated Vasculitis: Review of the 2022 American College of Rheumatology–European Alliance of Associations of Rheumatology Classification Criteria #ANCA #Vasculitis pubs.rsna.org/doi/10.1148/...

2024 American College of Rheumatology (ACR) Guideline for the Screening, Treatment, and Management of Lupus Nephritis acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

Familial Mediterranean Fever; Recent Advances, Future Prospectives 🤩 Wonderful review of #FMF, it’s a must! www.mdpi.com/2075-4418/15...

Systemic lupus erythematosus: one year in review 2025 🔸New insights into immune dysregulation 🔸Emerging treatments: Promising therapies 🔸Real-world impact: Anifrolumab and belimumab www.clinexprheumatol.org/article.asp?...

Pentose phosphate pathway metabolite restores T cell balance in SLE #SLE #LUPUS www.nature.com/articles/s41...

Even low levels of anticardiolipin antibodies are associated with pregnancy-related complications: A monocentric cohort study 🧵 #APS #Pregnancy #Antibodies obgyn.onlinelibrary.wiley.com/doi/full/10....

Just Autoimmunity? The Role of the Innate Immune Response in Lupus #Lupus #SLE #Autoimmunity journals.lww.com/jclinrheum/f...

Clinical and Imaging Pulmonary Manifestations in IgG4-Related Disease 🫁predominant subtype: septal thickening and increased bronchovascular tissue. 🫁 serum IgG4, which was higher in patients without pleuropulmonary involvement. #IgG4-RD #pulmonary #CT journals.lww.com/jclinrheum/f...

Recent advances in the diagnosis and management of neuropsychiatric lupus www.nature.com/articles/s41...

Levels of physical activity in a large international cohort of patients with systemic lupus erythematosus 👏🏻 inverse association between physical activity levels and fatigue, pain, stress or depression PRESCRIBE EXERCISE TO YOUR PATIENTS🫶🏼 lupus.bmj.com/content/12/1...

Executive summary: British Society for Rheumatology guideline on management of adult and juvenile onset Sjögren disease academic.oup.com/rheumatology...

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Serum Proteomic Markers in Patients with Systemic Sclerosis in Relation to Silica Exposure Very interesting article👏🏻 The identification of proteomic biomarkers could contribute to the phenotypic classification of patients and the development of personalised therapies. www.mdpi.com/2077-0383/14...

Incidence of #PneumocystisJirovecii Pneumonia and Prophylaxis-Associated Adverse Events Among Patients With Systemic #Lupus Erythematosus 🔎 Conclusions below www.jrheum.org/content/52/1...

Diagnostic, research, and real-life effect of the 2023 EULAR−ACR classification criteria for antiphospholipid syndrome #APL #antiphospholipid www.thelancet.com/journals/lan...

🔶Treat-to-target in SLE: is serology important? Results from an integrated analysis of five randomized clinical trials of five randomized clinical trials of belimumab 🔹🔹Normal serology enhances the protection of DORIS and LLDAS against severe and renal SLE flares academic.oup.com/rheumatology...

Hydroxychloroquine: A double‑edged sword (Review) strengthen the clinical use of HCQ for autoimmune diseases while highlighting the adverse effects that may occur during treatment. #SLE #HCQ #Treatment #autoimmune pmc.ncbi.nlm.nih.gov/articles/PMC...

Scandinavian retrospective study of 1,167 patients with GPA or MPA identified differences in clinical presentation between female and male patients and between patients with young vs older age at diagnosis of GPA In ACR Open Rheumatology acrjournals.onlinelibrary.wiley.com/doi/10.1002/... #Medsky

Avacopan Versus Prednisone Taper in Patients With ANCA-Associated Vasculitis Without Kidney Involvement in a Phase 3 Trial #ANCA #Vasculitis rheumnow.com/video-poster...

Evolution and trajectory of B-cell targeted therapies in rheumatic diseases ‼️20 years of clinical and translational insights drawn from B-cell targeted therapies for autoimmune diseases. www.thelancet.com/journals/lan...

#Hydroxychloroquine in patients with systemic #lupus erythematosus: how much is enough? With #HCQ at stable doses of 200 mg/day (or 3.0–3.5 mg/kg/day) as the background therapy in patients with #SLE, the majority of patients achieved prolonged remission. lupus.bmj.com/content/12/1...

Conducting a real-world study of Tumor Necrosis factor-alpha inhibitors-induced Systemic Lupus Erythematosus based on the FAERS database 〰️Different TNF-α inhibitors should be continuously monitored for SLE-induced complications www.nature.com/articles/s41...

Treatment guidelines for idiopathic inflammatory myopathies in adults: a comparative review #myopathies academic.oup.com/rheumatology...

NEW RESEARCH—Clinical manifestations, disease penetrance, and treatment in individuals with #SOCS1 insufficiency: a registry-based and population-based study bit.ly/3QKo0qx #RareDiseaseDay #Medsky #Rheumsky @alexandrebelot.bsky.social @institutimagine.bsky.social

Real-world oral #glucocorticoid use in #SLE: a nation-wide population-based study using the French medico-administrative (SNDS) claim database lupus.bmj.com/content/12/1...