Marton Olbei
@martonolbei.bsky.social
π€ 93
π₯ 314
π 14
Cytokine Networks
@imperialcollegeldn.bsky.social
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https://cytokinelink.org/
www.imperial.ac.uk/news/article...
Summary of our recent publication on cytokine networks in ulcerative colitis
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Decoding cellular conversations in ulcerative colitis reveals new drug targets
New research reveals previously hidden mechanisms driving inflammation and identifies new therapeutic targets, including some already showing success...
https://www.imperial.ac.uk/news/articles/medicine/metabolism-digestion-reproduction/2026/decoding-cellular-conversations-in-ulcerative-colitis-reveals-new-drug-targets/
8 days ago
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reposted by
Marton Olbei
Science Magazine
15 days ago
Through systems immunology analysis, a team has identified potential therapeutic targets for the treatment of
#UlcerativeColitis
, an inflammatory bowel disease characterized by dysregulated cytokine signaling in the GI tract.
#ScienceSignaling
https://scim.ag/4cdvxdv
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Decoding cytokine networks in ulcerative colitis to identify pathogenic mechanisms and therapeutic targets
Systems immunology reveals how cytokine-cytokine signaling is dysregulated in an inflammatory bowel disease.
https://scim.ag/4cdvxdv
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Why do many UC patients struggle despite cutting-edge biologics? We suspected the answer lies not in individual cytokines, but in how they communicate as an interconnected network during disease and treatment. Our new KorcsmarosLab paper published in Science Signaling
www.science.org/doi/10.1126/...
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Decoding cytokine networks in ulcerative colitis to identify pathogenic mechanisms and therapeutic targets
Systems immunology reveals how cytokine-cytokine signaling is dysregulated in an inflammatory bowel disease.
https://www.science.org/doi/10.1126/scisignal.adt0986
16 days ago
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reposted by
Marton Olbei
Waggoner Lab
17 days ago
Systems immunology reveals how cytokine-cytokine signaling is dysregulated in an inflammatory bowel disease
@martonolbei.bsky.social
@imperialcollegeldn.bsky.social
www.science.org/doi/10.1126/...
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reposted by
Marton Olbei
Saez-Rodriguez Group
5 months ago
π₯ Check out our new preprint on OmniPath, the prior knowledge resource for
#SystemsBiology
, and its brand-new OmniPath Explorer web app! π₯³ π Preprint:
www.biorxiv.org/content/10.1...
π Explorer:
explore.omnipathdb.org
OmniPath integrates 160+ resources for multi-omics analysis & modeling. π§Άβ¬οΈ
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Excited to share that I started a new chapter in my career as a Teaching Fellow at Imperial College London! I really enjoy teaching, and look forward to the opportunities and challenges ahead.
8 months ago
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reposted by
Marton Olbei
Saez-Rodriguez Group
11 months ago
π Update on our preprint about Gene Regulatory Net (GRN) benchmarking π We have included the original and decoupled version of SCENIC+, added a new metric and two more databases. Dictys and SCENIC+ outperformed others, but still performed poorly in causal mechanistic tasks.
doi.org/10.1101/2024...
π
add a skeleton here at some point
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Excited to share our work on UC cytokine networks at
#ECCO2025
. Come by poster P0104 if you are interested in: - how cytokines regulate each other in UC - the role of TL1A in treatment-naive UC - how we could use this approach to identify new drug targets
www.biorxiv.org/content/10.1...
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Decoding Cytokine Networks in Ulcerative Colitis to Identify Pathogenic Mechanisms and Therapeutic Targets
Ulcerative colitis (UC) is a chronic inflammatory disorder of the gastrointestinal tract characterised by dysregulated cytokine signalling. Despite the advent of advanced therapies targeting cytokine ...
https://www.biorxiv.org/content/10.1101/2024.09.12.612623v1.full
12 months ago
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Protocol for predicting host-microbe interactions and their downstream effect on host cells using MicrobioLink
Analyzing host-microbe interactions is essential for understanding how microbiota changes disrupt host homeostasis. Here, we present a protocol for prβ¦
https://www.sciencedirect.com/science/article/pii/S2666166724007354
about 1 year ago
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reposted by
Marton Olbei
Saez-Rodriguez Group
about 1 year ago
We present NetworkCommons, a unified platform πͺ for network biology, providing access to omics data, knowledge, and contextualization methods, all with a consistent API ππ§΅ Paper:
doi.org/10.1101/2024...
Docs:
networkcommons.readthedocs.io
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