www.imperial.ac.uk/news/article... Summary of our recent publication on cytokine networks in ulcerative colitis

Through systems immunology analysis, a team has identified potential therapeutic targets for the treatment of #UlcerativeColitis, an inflammatory bowel disease characterized by dysregulated cytokine signaling in the GI tract. #ScienceSignaling https://scim.ag/4cdvxdv

Why do many UC patients struggle despite cutting-edge biologics? We suspected the answer lies not in individual cytokines, but in how they communicate as an interconnected network during disease and treatment. Our new KorcsmarosLab paper published in Science Signaling www.science.org/doi/10.1126/...

Systems immunology reveals how cytokine-cytokine signaling is dysregulated in an inflammatory bowel disease @martonolbei.bsky.social @imperialcollegeldn.bsky.social www.science.org/doi/10.1126/...

🥁 Check out our new preprint on OmniPath, the prior knowledge resource for #SystemsBiology, and its brand-new OmniPath Explorer web app! 🥳 📖 Preprint: www.biorxiv.org/content/10.1... 🔍 Explorer: explore.omnipathdb.org OmniPath integrates 160+ resources for multi-omics analysis & modeling. 🧶⬇️

Excited to share that I started a new chapter in my career as a Teaching Fellow at Imperial College London! I really enjoy teaching, and look forward to the opportunities and challenges ahead.

📄 Update on our preprint about Gene Regulatory Net (GRN) benchmarking 📄 We have included the original and decoupled version of SCENIC+, added a new metric and two more databases. Dictys and SCENIC+ outperformed others, but still performed poorly in causal mechanistic tasks. doi.org/10.1101/2024... 👇

Excited to share our work on UC cytokine networks at #ECCO2025. Come by poster P0104 if you are interested in: - how cytokines regulate each other in UC - the role of TL1A in treatment-naive UC - how we could use this approach to identify new drug targets www.biorxiv.org/content/10.1...

We present NetworkCommons, a unified platform 🪐 for network biology, providing access to omics data, knowledge, and contextualization methods, all with a consistent API 👇🧵 Paper: doi.org/10.1101/2024... Docs: networkcommons.readthedocs.io