New study uses computational modelling + pseudotyped virus assays to identify broad-spectrum antivirals that block coronavirus cell entry. A step forward in rapid antiviral development. www.frontiersin.org/journals/mol... #Virology #PseudotypedVirus #DrugDiscovery #COVID19 #Pseudotyping

🧬This study used a luciferase-expressing influenza virus pseudotype to track infection in mice via bioluminescent imaging, following immunisation with a quadrivalent influenza vaccine. www.mdpi.com/1999-4915/17... #Influenza #PseudotypedVirus #VaccineResearch #Virology #Pseudotyping

This recent study highlights how contemporary HIV-1 clade C viruses circulating in India are evolving in ways that significantly affect the effectiveness of broadly neutralising antibodies. journals.asm.org/doi/10.1128/... #Virology #HIV #AntiViral #Virology #PseudotypedVirus

🧬 Could a probiotic be a vaccine? Mice given engineered E. coli produced SARS-Cov-2 neutralising antibodies, high IgA, CD8⁺ T cell activation & balanced cytokines. 🤔 Live bacteria as vaccine platforms—what's your take? 🔗 www.tandfonline.com/doi/full/10.... #Vaccines #SARSCoV2

🧬 New BASV Vaccine Study 🧪 Researchers immunised rabbits with four vaccine types targeting BASV glycoprotein and assessed neutralising antibodies using a pseudotyped virus microneutralisation assay. www.nature.com/articles/s41... #Vaccines #BASV #VaccineDevelopment #PseudotypedVirus

🚨Computationally designed peptides can block the SARS-CoV-2 spike protein from binding to human ACE2. PEP10, showed strong, stable binding in simulations which was tested using a pseudotyped virus system. 🔗https://www.mdpi.com/1420-3049/30/8/1750 #COVID19 #SARSCoV2 #Virology #DrugDiscovery

🧬This study investigates the antiviral potential of 5,6-dihydroxyflavone (5,6-DHF), a naturally occurring flavonoid, against betacoronaviruses including SARS-CoV-2 Omicron EG.5.1.1 and HCoV-OC43. www.sciencedirect.com/science/arti... #Virology #PseudotypedVirus #Antivirals #SARSCoV2

🔬Novel tri-specific antibodies demonstrate potent neutralisation of SARS-CoV-2 variants and related sarbecovirus pseudotyped viruses.🧬 onlinelibrary.wiley.com/doi/10.1002/... #Virology #Pseudotyping #PseudotypedVirus #Abs #Antivirals #COVID19 #SARSCoV2 #VirusNeutralisation

This recent preprint used HPV16 viral pseudotypes to explore the diversity and molecular characteristics of human monoclonal antibodies (mAbs) generated following HPV vaccination. #Virology #Pseudotyping #PseudotypedVirus #HPV #mAbs #Vaccination www.biorxiv.org/content/10.1...

The GamEvac-Combi Ebola vaccine, which employs rVSV and rAd5 vectors in a heterologous prime-boost format, was found to be safe and immunogenic in healthy adults in a phase 1-2 clinical clinical trial. www.frontiersin.org/journals/imm... #Virology #Vaccine #ClinicalTrials #EbolaVaccine

🧬Rabies Pseudotype Neutralisation Assay: A Safer, Faster Way to Monitor Vaccine Responses journals.plos.org/plosntds/art... #RABV #Rabies #Pseudotyping #PseudotypedVirus #Virology #HighThroughPut #NeutralisationAssay #PublicHealth #VaccineResearch

Congratulations double star @gl-hooper.bsky.social from the Edward Wright lab who presented both a poster AND a talk showcasing his research on a pan-lyssavirus vaccine and an African swine fever virus pseudotype at the annual @microbiologysociety.org meeting in Liverpool this week. 👊 #microbio25

🧪 Drug repurposing using pseudotyped virus A recent study used a SARS-CoV-2 pseudotyped virus system to screen drugs for potential inhibitors of viral entry. frontiersin.org/journals/pha... #PseudotypedVirus #SARSCoV2 #Virology #AntiviralResearch #COVID19 #VirusEntry #Pseudotyping

🚨New data on inhaled siRNA therapies for respiratory viruses! ascpt.onlinelibrary.wiley.com/doi/10.1111/... #COVID19 #SARSCoV2 #Antivirals #ClinicalTrials #RNAtherapy #Phase1Trial

🧬 DelS31 Mutation: A Key Player in COVID-19 Evolution 🧬 This study investigates the impact of the DelS31 mutation in JN.1-derived COVID-19 variants. journals.asm.org/doi/10.1128/... #COVID19 #SARSCoV2 #Pseudotyping #PseudotypedVirus #Vaccine

VH4524184 (VH-184), a third-generation integrase strand transfer inhibitor (INSTI), has shown promising results in a recent Phase 1 trial. read how they utilised pseudotyped virus here: linkedin.com/posts/george... #HIV #PseudotypedViruses #ClinicalTrials #Pseudotying #Antivirals

This study identifies MITD1 as a novel interferon-stimulated gene (ISG) capable of inhibiting multiple flaviviruses. www.pnas.org/doi/10.1073/... #Flavivirus #Virology #InfectiousDiseases #Immunology

The mRNA-1083 vaccine showed a good safety profile and strong immune response in a phase 1/2 trial, supporting further development as a single-shot vaccine for both flu and COVID-19. www.nature.com/articles/s41... #Vaccine #Covid #ClinicalTrial

🚨 New study on broad-spectrum HIV-1 inhibitors! Tested via pseudotyped virus & cell fusion assays, these NPIs offer promising potential. 🔗https://www.sciencedirect.com/science/article/pii/S2666517425000264?via%3Dihub #Virology #Pseudotyping #HIV #Antivirals #DrugDiscovery

🚨 Rabies-related virus detected in domestic cat in the Netherlands This case highlights the risks of rabies-related viruses in Europe and the importance of vaccination for pets with outdoor access. www.eurosurveillance.org/content/10.2... #Rabies #Lyssavirus #Virology #ZoonoticDiseases

🚨 We Want to Hear from You! 🚨Please take a moment to complete our quick 5-question survey. It will only take a minute, but your input will help shape the future of our work. 👉https://virion-dde96pr8.scoreapp.com #Virology #Research #VirionX #PseudotypedVirus #Pseudotyping #biotech

This study explored Exifone, a clinical polyphenolic compound, as a potential treatment for COVID-19. It binds to the SARS-CoV-2 3CL protease and disrupts ACE2/S-RBD interaction. lnkd.in/e7sMyMcB #Pseudotyping #Antiviral #COVID19 #Virology #SARSCoV2 #PseudotypedVirus

Bats are reservoir hosts of many viruses yet stay asymptomatic. A new preprint finds GBP5, a rapidly evolving immune gene, plays a key role in antiviral defence of HIV, VSV & lyssaviruses. www.biorxiv.org/content/10.1... #Virology #BatImmunity #ZoonoticViruses #Evolution #OneHealth

🚨 FINALLY OUT IN @Nature. A tour de force effort. 🦇 10 new bat genomes, excess of immune gene adaptations, species specific adaptations in ISG15, and anti-SARS-CoV-2 activity of bat ISG15. @hillermich.bsky.social @batresearch.bsky.social #LZCI #Bat1K www.nature.com/articles/s41...

Researchers captured MOKV and IKOV glycoproteins in pre- and post-fusion states, revealing pH-induced changes in membrane fusion. This study presents the first solved IKOV structure. journals.plos.org/plospathogen... #virology #Lyssavirus #IKOV #MOKV

Hell yeah! Virion X is a game-changer in virology research. Making vital info accessible is a smart move for innovation and public health. Can't wait to see the impact! 🚀💡 #Biotech #Disruption

🚀 Exciting news! We’re launching Virion X, a biotech dedicated to making critical virology research more accessible. We’re building a waitlist so you’ll be the first to know when we go live. lnkd.in/emSCjXcY #VirionX #Virology #Pseudotyping #Biotech #startup #pseudotypedvirus

Researchers have developed a recombinant ASFV-based bivalent vaccine candidate that protected against lethal challenges from both ASFV and CSFV in pigs. www.tandfonline.com/doi/10.1080/... #ASFV #CSFV #Vaccine #VaccineDevelopment #virology #veterinaryvirology

Researchers engineered a stable, prefusion Lassa virus GPC trimer, which, when used as an immunogen in animal models, elicited robust neutralizing antibody responses. www.nature.com/articles/s41... #virology #vaccine #LassaVirus #VaccineDevelopment #Immunology #EmergingViruses #Glycoprotein

This study identifies potent mAbs with strong neutralising activity against SARS-CoV-2. 2YYQH9 & LQLD6HL reduced lung pathology in XBB.1.16-infected hamsters, showing promise for future therapies. #pseudotyping #COVID19 #mAbs #virology🔗 translational-medicine.biomedcentral.com/articles/10....

This preprint uses pseudotyped virus deep mutational scanning to map HIV escape mutations against two broadly neutralising antibodies, 10-1074 & 3BNC117, revealing strain-dependent differences. #HIV #virology #antibodies #pseudotyping #pseudotypedvirus www.biorxiv.org/content/10.1...

This paper looks at population immunity to SARS-CoV-2 in south Africa following the emergence of the Beta VOC, using spike binding and pseudotyped virus neutralisation assays. #virology #pseudotyping #COVID19 #Immunology #Antibodies www.nature.com/articles/s41...

New preprint on canine viromes in Australia led by @jonathonmifsud.bsky.social. Includes the first RNA virus reported in dingoes - an unusual rotavirus A. Domestic dogs worldwide seem to carry a pretty similar set of viruses. www.biorxiv.org/content/10.1...

Nice review on African swine fever virus vaccine development. www.mdpi.com/1422-0067/26... #asfv #virology #vaccine

Novel Bridge Protein Strategy for Cell-Specific Delivery of Pseudotyped Viruses. #virology #pseudotyping #pseudotypedvirus #tropsim #proteinengineering www.sciencedirect.com/science/arti...

Amantadine analogues inhibit drug-resistant influenza A: blocking pseudotyped virus entry & disrupting M2-M1 interactions. Promising for future antivirals for drug-resistant IAV. www.sciencedirect.com/science/arti... #Influenza #Antivirals #DrugResistance #Virology #pseudotyping

Targeting SARS-CoV-2 spike HR2: Researchers designed HR212, a recombinant protein that inhibits viral infection across 28 pseudotyped variants. This highlights its potential as a broad-spectrum antiviral. #COVID19 #virology #pseudotyping #antiviralresearch onlinelibrary.wiley.com/doi/10.1002/...

Developing a high-titre VSV-based pseudotyped virus for HCoV-NL63, researchers enhanced infection efficiency by truncating the spike protein, which they use for antiviral screening. www.sciencedirect.com/science/arti... #Virology #Pseudotyping #DrugDiscovery

Great concise review of African swine fever virus. It highlights the ongoing threat of African Swine Fever, recent advances in diagnostics and vaccine research, and the persistent challenges in controlling its spread. #ASFV #virology pubmed.ncbi.nlm.nih.gov/39713833/

This preprint explores how past SARS-CoV-2 exposure shapes immunity. Adults imprinted by early strains target RBD, while XBB*-infected infants focus on NTD. Vaccination shifts infants’ response to RBD but with different targets. #virology #COVID19 www.biorxiv.org/content/10.1...

This study reveals that Sudan ebolavirus glycoprotein binds to the human NPC1 receptor ~9 times more strongly than Ebola virus glycoprotein. Identifying 4 key residues that differ in binding from EBOV. #virology #EbolaVirus #SUDV www.nature.com/articles/s42...

A new bivalent VSV-based vaccine targets SARS-CoV-2 & influenza A, inducing strong immune responses in mice. It protects against both viruses & cross-protects against flu strains, offering promise for a broad-spectrum respiratory vaccine. #Vaccines #pseudotyping www.science.org/doi/10.1126/...

This study examines WCBV and LLEBV in Miniopterus schreibersii across Europe, highlighting WCBV's significant risk and the urgent need for surveillance due to ineffective rabies vaccines and treatments. #virology #RABV #WCBV #lyssavirus www.cell.com/iscience/ful...

Nano-acoustics could enable viral fingerprinting via ultrafast spectroscopy. Vibrations at 19–21 GHz reveal morphology/protein interactions, while 2–10 GHz modes track disassembly. This label-free method could advance diagnostics and research. #virology #pseudotyping www.pnas.org/doi/10.1073/...

A study on vampire bat rabies in Latin America (1970–2023) shows rising cross-species transmission post-2002, signaling re-emergence. Rabies causes 450 cattle outbreaks/year, hitting Brazil, Colombia, Peru & Mexico hardest. journals.plos.org/plosone/arti... #Rabies #RABV #virology

This recent study used pseudotyped virus assays to show that DCoVs enter DF-1 cells via clathrin-mediated endocytosis, relying on clathrin, dynamin-2, cathepsins, and low pH, while independent of caveolae/macropinocytosis. #pseudotyping #virology veterinaryresearch.biomedcentral.com/articles/10....

This paper outlines a protocol to assess humoral immune responses in mice post-SARS-CoV-2 vaccination. It features ELISA for spike-specific binding antibodies and a pseudotyped virus neutralization assay for neutralizing titers. #pseudotyping #COVID19 #vaccine www.sciencedirect.com/science/arti...

Maikoo et al. have developed a HIV-1C latency model. Revealing that the HIV-1C consensus LTR exhibited a lower reactivation potential compared to its HIV-1 subtype B counterpart. #Virology #pseudotyping #HIV www.sciencedirect.com/science/arti...

Check out our recent review on "Cell entry mechanisms of African swine fever virus" #ASFV #virology www.sciencedirect.com/science/arti...