Can natural cycles be effectively utilized in women of advanced maternal age undergoing oocyte donation? 👀 To explore the answer, join the next #ESHREjc 📍May 29th, 17:00 CET 👉Featured paper: academic.oup.com/humrep/advan... Short summary (what we call “skytorial” or “bluettorial”) provided below👇

🚨🚨Scientific Speed Dating is back at the ESHRE Annual Meeting 2026! ⚡ Whether you’re looking for future collaborators, mentorship, research discussions, or simply to expand your network; this is the place to connect! 📍 London | #ESHRE2026 👉 Save your spot: lnkd.in/eVMhaDCf @eshre.bsky.social

🚨🚨🚨 Scientific Speed Dating returns to the #ESHRE Annual Meeting in London❗ 🚨🚨🚨 🌟 Meet experts and peers in reproductive medicine to exchange ideas, build connections, and discover new opportunities 🌟 First come, first served — don’t miss your chance to join 👉 lnkd.in/eVMhaDCf #ESHRE2026

🎉 The Scientific Speed Dating is back at #ESHRE2026 in London! 🎉 👩🏼‍🔬 junior #ReproMed professional? 💡 Share ideas, spark collaborations, and explore new opportunities ⏳ First come, first served - register now to secure your place! 🔗 www.eshre.eu/ESHRE2026/Pr... Co-organised by the #ESHREjc & YTG

Grow your network, level up your sci-comm, and step into the spotlight at #ESHRE2026 🤳 Apply now to become one of the 5 Young Ambassadors of the 42nd Annual Meeting!✨ Being one of #ESHRE5 back in 2024 was an unforgettable experience - highly recommend it ✅ Your turn to take the stage 😎🤓

🎉 Scientific Speed Dating returns at #ESHRE2026 in London! 🎉 👩🏼‍🔬 Junior professionals don’t miss this chance to connect with leading experts. 💡 Exchange ideas, spark collaborations, & discover new opportunities. 👥 Secure your spot ! Co-organised by the #ESHREjc & Young Talent Group #ESHRE

Great news for #ESHRE2026 attendees! 🎉 Scientific Speed Dating is back, bigger than ever. 🗓️ Mon 6 & Tue 7 July - 10:30–11:30 CEST Meet dozens of peers in under an hour. Junior meets senior. Ideas spark. ❗120 in-person spots. Deadline to apply extended until 15 May 2026! www.eshre.eu/ESHRE2026/Pr...#ESHRE2026

Thanks to all participants & experts! It was such a great discussion! 🙌🏼 See you in May 👋🏼🔜 #ESHREjc

Also a big thank you to our fantastic moderators for leading such an engaging and insightful discussion 👇 @gliperis.bsky.social @dkalaitzopoulos.bsky.social @juanjo-fraire.bsky.social @ribeirosara.bsky.social Your energy and thoughtful moderation made this #ESHREjc truly outstanding 👏

A big thank you to our amazing experts for making this discussion truly outstanding 👇 @prof-lotti.bsky.social @smdsresearch.bsky.social @drdanielmarcu.bsky.social @mvazquezlevin.bsky.social @drlucaboeri.bsky.social Your expertise and insights made the difference. #ESHREjc

A big thank you to everyone who joined this lively edition of the #ESHREjc! 🦋 It was a pleasure to see such engaging discussions and insightful contributions from all participants and experts. Truly grateful to have shared this with such a fantastic community... looking forward to the next one! 🙌

Many thanks to all participants, experts and to @mr-att.bsky.social and his team for leading this lively edition of the #ESHREjc 🦋 See you next time! 🙌

💬 Q4 Summary is out! Good counselling isn’t just prognosis. 👉 Clear steps, follow-up, and support are key to reduce patient distress. #ESHREjc

🔬 Q3 Summary is out! Why do controlled models show weaker male effects? 👉 Oocyte repair capacity may mask sperm damage... but only up to a point. #ESHREjc

🧬 Q2 Summary is out! OAT-S and NOA are not one entity. 👉 Biology, epigenetics, and confounders all interplay... how much is intrinsic vs contextual? #ESHREjc

🧠 Q1 Summary is out! Severe male factor may not affect neonatal outcomes... but it impacts time, cycles, and patient burden. 👉 Time-to-live-birth matters. #ESHREjc

Indeed, although propensity score matching was used to control for key confounders, residual confounding cannot be excluded, particularly regarding female-related factors that strongly influence IVF/ICSI outcomes, such as oocyte quality and endometrial receptivity. #ESHREjc

Every couple is different and should be approached individually, with clear expectation management. The focus should be on strategies to improve outcomes, including antioxidant supplementation, which, although still under investigation, may improve semen parameters, particularly in OAT-S #ESHREjc

Q4: How can doctor-patient communication effectively integrate prognosis and expectation adjustment in severe male infertility (OAT-S, cryptozoospermia, NOA) without increasing couples’ emotional distress? #ESHREjc

These findings challenge the long-standing perception of ICSI as a complete equalizer of male factor infertility. Instead, they reinforce the biological relevance of sperm-derived contributions to early embryogenesis, likely reflecting underlying genomic and epigenetic integrity. #ESHREjc

The data compellingly demonstrate that severe MF infertility—particularly severe OA (in paper OAT) and NOA—is not fully mitigated by ICSI. Rather, it remains significantly associated with impaired fertilization, reduced embryo developmental competence, and lower cumulative live birth rates. #ESHREjc

Q2: #ESHREjc Are poorer outcomes observed in severe OAT-S and NOA mainly driven by sperm DNA damage and epigenetic defects, or are they still partly explained by residual female and treatment-related confounding?

#ESHREjc Hello Everyone! One of the most persistent assumptions in ART is that ICSI has effectively overcome male infertility impact. But has it? This study addresses whether male infertility is merely a barrier to fertilization or a determinant of reproductive success across the entire ART.

Delighted to contribute to this discussion. Male fertility has remained underfunded and under-researched for decades, even though male factors contribute to around half of infertility cases. It is time to give male reproductive health the scientific attention it deserves. #ESHREjc

Q1: If severe male-factor infertility impairs fertilization and embryo development but not neonatal outcomes among live births, how should this change clinical counselling and treatment strategy? #ESHREjc

The important role of male in treatment outcomes will be discussed in this #ESHREjc edition!

🚨Revisit the #bluettorial for the discussed paper 👇 #ESHREjc

If you would like to join use the #ESHREjc hashtag

Do not forget the #ESHREjc in your comments!

We are delighted to introduce the experts joining our jc 👨‍⚕️ @prof-lotti.bsky.social 👩‍⚕️ @smdsresearch.bsky.social 👨‍⚕️ @drdanielmarcu.bsky.social 👩‍⚕️ @mvazquezlevin.bsky.social 👨‍⚕️ @drlucaboeri.bsky.social A fantastic panel bringing together expertise in male infertility and reproductive medicine. #ESHREjc

Welcome to the March #ESHREjc 🙌🏼 Check the paper under discussion 👇🏼

🚨🚨🚨 **WELCOME everyone to the 54th ESHRE Journal Club** 🚨🚨🚨 📣We are ready to talk about: How different male infertility phenotypes may impact IVF/ICSI outcomes and why this distinction could matter more than we think. PAPER ➡️ pubmed.ncbi.nlm.nih.gov/41394017/ #ESHREjc

For those who have not had the chance to read the paper our moderators have created a great Skytorial 👉 bsky.app/profile/mr-a... #ESHREjc

This edition’s paper is “Do different male infertility factors impact embryological, cumulative pregnancy and neonatal outcomes in IVF/ICSI cycles? A retrospective cohort study” published in our academic journal Human Reproduction Open 👩‍🎓 🔗 doi.org/10.1093/hrop... #ESHREjc

@mr-att.bsky.socialwill be the lead moderator of this #ESHREjc – thank you Attilio, the floor is yours 😊

Housekeeping essentials 👇 1. Use the hashtag #ESHREjc in all your posts 2. The #ESHREjc will take place over the weekend starting now until tomorrow 28 March 17.00 CET 🕔 3. Please always comment in the thread of the questions (they will be identified with Q1, Q2, …)

Welcome everyone, we are back for the 54th edition of the #ESHREjc 🙌 🦋

🕒 ~24 hours to go! We often label “male factor infertility” as one single entity… 👉 but is that biologically accurate? Join us at #ESHREjc on 27th March 2026 💬 Be ready to share your thoughts, challenge assumptions, and take part in the discussion. We look forward to seeing you there!

💡 We often say “male factor infertility”… But are we oversimplifying? 👉 Should we start thinking in terms of particular male factor instead? Join us for the discussion at #ESHREjc – 27th March 2026 -17.00 CET 👇 Curious to hear your thoughts!

🧬 Why? ICSI bypasses mechanics… but NOT biology: DNA damage oxidative stress epigenetics 👉 These still affect embryo competence. #ESHREjc

📉 Clinical impact: OAT-S → lower cumulative live birth NOA → lower CLBR + higher miscarriage 👉 Sperm quality still matters. Meanwhile 👇 MMF, OA, teratozoospermia, donor sperm: ➡️ outcomes similar to normozoospermia 👉 Not all male factor is equal. #ESHREjc

ICSI bypasses: ❌ motility ❌ zona binding But NOT: ✅ DNA integrity ✅ epigenetics #ESHREjc

🧠 Key question: Does sperm still matter in the ICSI era? Or does ICSI fix everything? 🔬 Findings: Severe male factor (OAT-S, NOA): ↓ fertilization ↓ blastocyst formation ↓ embryo utilization 👉 Even with ICSI. #ESHREjc

Instead of “normal vs abnormal”, men were stratified into: ✴️MMF (Mild–Moderate Male Factor) ✴️OAT-S (Severe Oligoasthenozoospermia) ✴️OA (Obstructive Azoospermia) ✴️NOA (Non-Obstructive Azoospermia) ✴️Teratozoospermia ✴️Donor 👉 A much more biologically meaningful approach. #ESHREjc

📊 ~15,000 first IVF/ICSI cycles Propensity score matching Focus on cumulative live birth rate (CLBR) 👉 Not just embryos. Real outcomes. #ESHREjc

Male infertility affects up to 50% of couples, and sperm counts are declining worldwide. While ICSI revolutionized treatment, we still don’t fully understand how different male infertility factors impact embryo development and live birth outcomes. Let’s dive in 👇 #ESHREjc

We often label “male factor infertility” as 1 entity. 🤔but is this right? To find out join #ESHREjc on Friday 27th of March starting at 17:00 CET @prof-lotti.bsky.social @smdsresearch.bsky.social @drdanielmarcu.bsky.social Monica Vazquez-Levin Luca Boeri PAPER➡️ pubmed.ncbi.nlm.nih.gov/41394017/

Great news for #ESHRE2026 attendees! 🎉 Scientific Speed Dating is back, bigger than ever. 🗓️ Mon 6 & Tue 7 July - 10:30–11:30 CEST Meet dozens of peers in under an hour. Junior meets senior. Ideas spark. ❗120 in-person spots. Deadline: 31 March. www.eshre.eu/ESHRE2026/Pr...#ESHRE2026#Networking

The numbers tell a story we need to change 📊⚡ Women are ~50% of the world, yet <30% of researchers. Closing the gap means better science: →More diverse ideas →More inclusive research →Solutions for all At #ESHRE, we believe gender equity in #STEM drives progress. Who inspires you in science?