🎉 Scientific Speed Dating returns at #ESHRE2026 in London! 🎉 👩🏼‍🔬 Junior professionals don’t miss this chance to connect with leading experts. 💡 Exchange ideas, spark collaborations, & discover new opportunities. 👥 Secure your spot ! Co-organised by the #ESHREjc & Young Talent Group #ESHRE

Q1: If severe male-factor infertility impairs fertilization and embryo development but not neonatal outcomes among live births, how should this change clinical counselling and treatment strategy? #ESHREjc

The important role of male in treatment outcomes will be discussed in this #ESHREjc edition!

If you would like to join use the #ESHREjc hashtag

#eshreJc is back 🤩

Join the #ESRHEjc for an important topic! 💫

🔥 Thank you everyone for attending the #ESHREjc and the first one hosted on Bluesky Many thanks to our experts for the insightful discussion on the multifaceted role of the oocyte cortex @rvassena.bsky.social @paolavigano.bsky.social And the # ESHREjc team 💫 Until next time! 👋🏻

Question 3 summary of usable clinical markers from the discussion 👇🏻 #ESHREjc

Here the summary of our discussion for Q3 on biomechanic parameters of oocyte developmental competence #ESHREjc @eshre.bsky.social

On question 2 of the #ESHREjc here the summary of the discussion on the role of the oocyte cortex in downstream embryo development 👇🏻

What have we been discussing during the #ESHREjc discussion on the oocyte cortex? Have a look at the summaries starting with q1 on its role in maturation 👇🏻

Follicular markers can be indicative but face practical difficulties in clinical settings 👇🏻 #ESHREjc

Could we find ways to predict oocyte survival post egg freezing cycles? This would be a game changer in counselling for patients undergoing egg freezing for fertility preservation and social reasons #ESHREjc

How does the follicular environment might affect 👇🏻#ESHREjc

On this, I am team pipette. It's not invasive, positioning by the embryologist and automated measure (think of the automated blood pressure band on the arm). The question is, as always, one of sensitivity and sensibility, still very much to be tested. #ESHREjc

We have to assume that trancriptomic profile is able to quantify/reflect mechanical forces. #ESHREjc

In the fruit fly embryos, mechanical forces modulate the expression of some genes 😎 we would need to look in humans. Maybe blastoids could help?! #ESHREjc www.cell.com/fulltext/S15... Tissue Deformation Modulates Twist Expression to Determine Anterior Midgut Differentiation in Drosophila Embryos

Impressive that this paper on characterization of the injection funnel during ICSI has 10 years....new findings can revive older evidence.#ESHREjc

At the moment, data available finds a difference in biomechanical parameters that can lead to embryo viability and live birth. But the cause of this abnormal parameters will be difficult to adress #ESHREjc

Question 4 on cortex effects on paracrine interactions #ESHREjc 👇🏻

2/2 Major barriers to clinical 🧑🏻‍⚕️ translation remain throughput, operator dependency, lack of standardization, and crucially proving added predictive value beyond existing morphological and morphokinetic markers. 🚨🚨🚨 #ESHREjc

Building on Coticchio et al., cortical mechanics as biomarkers is not entirely speculative. For example, Yanez et al. (PNAS, 2016) showed that oocyte stiffness measured by AFM correlates with meiotic competence and spindle integrity. #ESHREjc

Question 3 on clinical markers of cortical activity is now live. Join the #ESHREjc discussion 👇🏻

Data from emerging optical microscopy approaches needed 📣 #ESHREjc

Multilayered control 🪖⛑️🧢👇🏻 #ESHREjc

Fyn-null oocytes have problems in maintaining cortical integrity....they are subfertile #ESHREjc

Studying ectopic chromosomal signaling that misactivates RhoA–myosin II at the cortex is fundamental to understanding this key mechanism underlying abnormal cleavage and fragmentation. #ESHREjc

The effects of cortical dysregulation in embryo development are discussed in the 2nd question of the #ESHREjc 👇🏻

Appropriate stiffness due to acto-myosin network is crucial for splindle positioning and PB extrusion. #ESHREjc

The #ESHREjc is underway 👇🏻

Revisit the #bluetorial for the discussed paper 👇🏻 #ESHREjc

WELCOME everyone to the first #ESHREjc on Bluesky to talk all about the Oocyte Cortex: Fertility’s Hidden Control Layer #ESHREjc Paper ➡️ pubmed.ncbi.nlm.nih.gov/41206604/

Are you ready for the #ESHREjc? Starting in couple of hours, join the discussion on the versatile functions of the oocyte cortex over a 24h window! @rvassena.bsky.social @paolavigano.bsky.social @enricabianchi.bsky.social

🧬 The Oocyte Cortex: Fertility’s Hidden Control Layer 
To find out join #ESHREjc on Friday 29/1 starting 17:00 CET. @paolavigano.bsky.social @rvassena.bsky.social @enricabianchi.bsky.social&authors Giovanni Cotichio and Danilo Cimadomo Paper ➡️ pubmed.ncbi.nlm.nih.gov/41206604/ 🧵 #bluetorial 👇🏻

🚨 The #ESHRE journal club is now on Bluesky! Is the oocyte cortex the hidden key to egg quality, fertilisation, and embryo development? Join us for the next #ESHREjc 🗓 30–31 January ⏰ 17:00 CET start-stop academic.oup.com/humrep/artic... Experts 👉🏻 RitaVassena @paolavigano.bsky.social