#2027ISMPMI - Try 2 for Jeju, Korea! Hope to see you there and I’m glad that South Korea gets to host after their turn was missed because of the pandemic. There is a promise of good food 🤤 Though I may need to start saving up now with the state of things… #2025ISMPMI

Mary wildermuth #2025ISMPMI gives the best introduction to the Powdery mildew fungus :)

#2025ISMPMI Songyuan Zhang from the Zipfel lab is learning from nature how to engineer new MAMP receptors. Great results.

#2025ISMPMI Benjamin Menn presents an elegant yeast surface displace screen to identify new carbohydrate binding receptors of plants.

#2025ISMPMI Thi Bich Luu wants to make a difference by transferring Nod factor susceptibility to barley, maize and other cereals. Taking candidate homolgs of NFR5 receptor and by domaine swapping chimaric receptors are build.

#2025ISMPMI Rhizobia and Haber-Bosch good bye? Luis Rubio goes for the challenge on reconstituting nitrogen fixation directly in plants by targeting around 20 needed components in Mitochondria in a step-wise process.

@kenichitsuda.bsky.social is introducing the Concurrent sessions on biotic/abiotic trade-offs in plant-microbe interactions #2025ISMPMI

www.biorxiv.org/content/10.1... Up next at #2025ISMPMI @kseniakrasileva.bsky.social discussing work on protein language model for receptor engineering.

@kseniakrasileva.bsky.social is the first talk at the engineering traits session at #2025ISMPMI Branching into PRRs thanks to @danimstevens.bsky.social. The ?: Can we use language models to predict host and microbe proteins interaction outcomes? The answer: Yes! New “mamp-ml”does pretty well.

#2025ISMPMI - first new to nature chimeric NLR sensors being created, with integrated domains that do not have sequence or structure matches in the recorded life - raises questions on assessing biosafety & food safety aspects for these immune receptors for lab and field studies.

@angusb.bsky.social wants to engineer plant resistance proteins (NLRs) from scratch. Can we create protein domains to integrate into NLRs to catch pathogen effectors? New tech makes this possible now. Chose Magnaporthe and Fusarium effectors as targets - many steps later, it worked! #2025ISMPMI

Dani’s recent paper appears to be the top #2025ISMPMI post which is impressive for someone not here 💓 bsky.app/profile/dani...

In the trait engineer session and Aurelia Rakotondrafara makes a quip that her talk has no AI 😅 Under-revision-study from her lab uses a treatment of a mycovirus protein to reduce growth and increase fungicide susceptibility of the pathogen Sclerotinia sclerotiorum. #2025ISMPMI

#2025ISMPMI Aurelie Rakotondrafara shows very interesting effects of mycovirus infection of Sclerotinia on virulence on the host plant. Take home to use mycoviruses and plant viruses to limit the spread of fungal pathogens.

#2025ISMPMI Agnus Bucknell of the Talbot lab gives an exciting presentation to engineer fungal effectors recognizing immune sensors based on Pik1. Great and clear talk.

#2025ISMPMI Ksenia Krasileva gives an impressive talk on predicting receptor-ligand interactions. CHECK OUT mamp-ml!

TODAY. 15:15 @ Room P&Q #2025ISMPMI

#2025ISMPMI Oswaldo Valdes-Lopez points out that other nutrients beside Nitrogen limitation are important cues to decide on symbiosis with rhizobia. Phosphate limitation negatively impacts nodule formation.

#2025ISMPMI Evans Lagudah gives a beautiful and clear talk on the challenge to find durable and broad resistances. Most are genes of whatever type show race specificity but Lr34, Lr67 and Lr46 are encoding for membrane transporters showing a pathogen-attenuating resistance.

We start the last day of #2025ISMPMI with Renier van der Hoorn who will present his pioneering work on how pathogens manipulate apoplastic defence

Jian-Min Zhou shows unpublished data related to ZAR1 signaling and what other players are required in planta for activation of the resistosome and localization in the plasma membrane. Find similarity with a salt stress response. #2025ISMPMI

#2025ISMPMI Jian-Min Zhou calls for more interdisciplinary approaches in plant microbe research to bring our research to the next level. He gives insights on ZAR1 signalling. Zar1 influences SYT1 distribution in a Ca2+ binding dependent manner.

#2025ISMPMI the great Renier van der Hoorn starts the plenary with exciting research about the apoplastic battlefield in bacterial-plant interactions. Hydrolases and inhibitors all around...glycosyrin inhibitor pathway is conserved and spread inhibiting galactosidases and glucosidases.

Arabidopsis thaliana CELLOX1 limits fungal colonization in roots. Nice talk by Giulia Peruzzi at #2025ISMPMI, @ceplas.bsky.social

www.nature.com/articles/s41... Remodelling autoactive NLRs for broad-spectrum immunity in plants

AUXIN 2026 logo competition! Please re-post. Deadline for submissions is Tuesday July 15th. Prize is free registration worth €500+ Auxin2026: auxin2026.info Send submissions to [email protected] @larsostergaard.bsky.social @luciastrader.bsky.social @dolfweijers.bsky.social

I was explaining to my Ukrainian colleague the phrase ‘There’s no such thing as a free lunch’. She told me the equivalent in Ukrainian is ‘The only free cheese is in the mousetrap’ - which is so much better

#2025ISMPMI moving to plant bacterial symbiosis, Fang Xie shares fascinating data on the molecular players on the plant side to invite the rhizobia in. Ncd1 is expressed in nodules and is essential for N fixation.

#2025ISMPMI Stella Cesari gives a beautiful presentation on her research on MAX effectors. Avr-Pia binds to HMA domain of rice HPP09. Screens reveal many interactions with rice proteins. Highlight: Avr-Pib interacts with MAPKKK.

#2025ISMPMI tremendous effector-NLR screen with 1617 plants presented by Yin Yan. Following up new avr-R gene couples.

Peter Dodds kicking off the crop resistance session at #2025ISMPMI : an Avr atlas for (rust) disease resistance!

#ISMPMI Martin Stegmann from Uni Ulm on the perception of CEP peptides, which were first described to play a role root nod nematodes. These days we know they are crucial phytocytokines & Martin demonstrates the function in immuniy

Luyao Wang presents very interesting work on NLRs and specifically at Rpi-cjm1 of potato and another integrated domaine HMA R-gene Rpi-brk1

#2025ISMPMI Oliver Powell presents bioinformatic work in chinese spring genome identifying a new class of R genes, kinase fusion proteins.

3x Posters from the Djamei lab @effectomics.bsky.social @unibonn.bsky.social Today: Me #123 effector-effector PCD suppression? Tomorrow two top PhD students: Riaz Tabassum #88 early-expressed Ustilago effectors Komal Pervaiz #206 Magnaporthe vs microbes!

#2025ISMPMI Corinna Thurow reveals their exiting findings that transdifferentiation induced by Verticillium dahliae is achieved by the TRADE effector targeting Varicose host scaffold protein.

#2025ISMPMI Wei Wang from the Birch-lab presents how they dissect effector secretion pathways for apoplastic and translocated effectors. Nice work!

#2025ISMPMI Youhuang Xiang from Roger Innes lab presents the TPP1 effector of Fusarium graminearum. A protease that localizes specific to the chloroplast and suppresses in its precursor form ETI.

#2025ISMPMI Manuel Gonzalez Fuente from the Üstün lab shows how pathogens like Pseudomonas target p bodies with effectors HopM1 and HopN1. ER stress induction by HopM1 counteracts p bodies.

#2025ISMPMI Qun Liu from the Hogenhout lab shows convincing data that the aphid derived CathB6 recruits EDS1 into p-bodies to promote aphid fecundity. ACD28.9 protein acts against CathB6 activity.

#2025ISMPMI Trang Phang from the Lahaye-lab shows her unpublished and cool results on the water soaking inducing CsLOB1 transcription factor targeted by Tal effector. CsLOB1 directly promotes cell wall degradation.

#2025ISMPMI Joo Hyun Lee reveals her findings on Ca2+ channel manipulation by Avrblb2.

I am looking for a (bio)chemist to join the lab and help us making affinity-based probes for proteases! The project is truly interdisciplinary with a strong computational chemistry component, peptide synthesis and plant biochemistry! Text me if interested and please spread the word!

Wolf Frommer presents work from @healthycrops.bsky.social, a global collaboration to work on bacterial blight of rice. They are transferring transgene-free, genome edited rice to different countries, with legal frameworks in place, to test resistance to Xanthomonas oryzae pv. oryzae. #2025ISMPMI

#2025ISMPMI Dapeng Li shows beautiful unpublished work how plants assemble at the ER Enzymes to compartimentalize defense compound production to avoid self toxification.

#2025ISMPMI Wolf Frommer presents about the sweet secrets of Xanthomonas host plant interactions. Using this knowledge in a collaborative effort to generate Xanthomonas resistant rice varities for local producers.

NRG1 target membranes of mitochondria, chloroplasts and the ER

#2025ISMPMI beautiful confocal microscopy of the Bozkurt-lab reveals that NLRs trigger immunity by interacting with more then only plasma membranes.

#2025ISMPMI Also Botrytis has two nuclei but are still haploid with distributed chromosomes. Great work of the Xin Li Lab.