1/ Missense variant effect predictors (VEPs) are very accurate but are they trustworthy? Not if their probability outputs aren’t calibrated. Our new method, RaCoon, fixes this by calibrating VEPs at the residue level, where miscalibration actually happens. www.biorxiv.org/content/10.1...

Still time to register for the next CAPRI round and put your methods to the test for predicting the structure of four antibody-antigen complexes - prediction period opening on Sept. 29th.

The second annual ALADDIN project meeting has come to an end! 👏 We thank our hosts from @liu.se for a well-organised meeting and our project partners for their presentations & insightful conversations. As we approach our halfway milestone, things will only speed up! #EICPathfinder

Unfortunately it’s clear that the Israeli people can’t topple the government or change its ways. Seems like the attorney general, the last gate keeper, will be fired soon. As long as we’re stuck with this government, the war won’t stop. Only international intervention (=the U.S) might do it.

A small reminder to all structural biologists around working on biomolecular complexes: please consider sharing your complexes as targets for CAPRI - AI has not solved all structure prediction problems and there are still challenges! See www.capri-docking.org/contribute/

The first comprehensive atlas of allele-specific DNA methylation www.nature.com/articles/s41...