Trinity Cookis
@trinitycookis.bsky.social
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reposted by
Trinity Cookis
Nogales Lab
about 1 year ago
Work led by graduate student
@trinitycookis.bsky.social
and coauthors Alexandria Lydecker,
@paulsauer.bsky.social
, and
@kasinath-lab.bsky.social
is out today where we looked at the inhibition of PRC2 by histone PTMs associated with regions of active transcription.
www.nature.com/articles/s41...
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Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications - Nature Structural & Molecular Biology
Structures reveal that histone H3K36me3 and H3K4me3 modifications reduce Polycomb repressive complex 2 (PRC2) function through the inhibition of histone tail engagement and antagonistic binding to the...
https://www.nature.com/articles/s41594-024-01452-x
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