Paul Sauer
@paulsauer.bsky.social
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Structural Biologist and outdoor enthusiast
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Paul Sauer
Marisa Kabas
8 months ago
๐จ BREAKING: OMB has just issued a memo *rescinding* the previous memo freezing all federal financial assistance programs. Full text, per government source:
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Our first paper here at
#interdictbio
!
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9 months ago
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reposted by
Paul Sauer
Karolin Luger
9 months ago
As someone who grew up in Austria I am really concerned about the apparent lack of concern. y'all should distribute the small book 'Biedermann und die Brandstifter' by Max Frisch ("The Fire Raisers: A Morality Without a Moral,"), which lays it out in detail. ๐งต
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reposted by
Paul Sauer
Steven Cheng
9 months ago
"On a molecular level, our structural studies reveal that interdictors bind in a linkerless heterobifunctional manner to both the rRNA and the nascent peptide chain ... much the way a PROTAC can be modularly designed and constructed"
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Paul Sauer
John Prensner
9 months ago
Is RNA translation the next hot area in
#cancer
therapeutics? Take a look and make a decision for yourself!
#RNAsky
#ONCSky
๐งฌ ๐ป
#genomics
www.biorxiv.org/content/10.1...
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Context-dependent translation inhibition as a novel oncology therapeutic modality
Inhibitors of protein synthesis, including anisomycin, homoharringtonine, and other natural products bind in the peptidyl-transferase center (PTC) of the eukaryotic ribosome to inhibit translation. Re...
https://www.biorxiv.org/content/10.1101/2025.01.09.632223v1
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Congratulations
@trinitycookis.bsky.social
for a great paper! Biochemical and structural disscection of PRC2 activation and inhibition by modified histones!
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9 months ago
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