Isoindolines and Isoindoline-1,3-diones as Nonpeptide ACE Inhibitors: An In Silico and In Vitro Modeling Approach pubs.acs.org/doi/10.1021/... #KellyChibale #MedicinalChemistry #Hypertension #CardiovascularResearch #ACEInhibitors #DrugDiscovery #ComputationalChemistry

Discovery of Niclosamide Analogs with Potent Mitochondrial Uncoupling Activity and Reduced Mitochondrial Inhibition–Associated Toxicity pubs.acs.org/doi/10.1021/... #KellyChibale #MedicinalChemistry #CancerResearch #MitochondrialBiology #OncologyResearch #DrugDiscovery #QSAR

Maltose-Conjugated Thiosemicarbazones from Substituted Benzaldehydes: Synthesis and Inhibitory Activity against Gram-(+) and Gram-(−) Bacteria pubs.acs.org/doi/10.1021/... #KellyChibale #MedicinalChemistry #AntimicrobialResistance #AntibioticDiscovery #InfectiousDiseases #ChemicalBiology

Now also an Honorary Fellow of the #RoyalSocietyofChemistry, its highest accolade. Encouraging to see recognition of science that combines excellence, leadership and societal impact. Read more: www.rsc.org/news/2026-ho... #KellyChibale #HonoraryFellow #ChemicalSciences #H3D #GlobalScience

Design, Synthesis, and Structure–Activity Relationship Studies of 7H-Pyrrolo[2,3-d]pyrimidine Derivatives as Potent Casein Kinase 1α (CK1α) Inhibitors @acs.org pubs.acs.org/doi/10.1021/... #KellyChibale #CancerResearch #Leukaemia #TargetedTherapy #KinaseInhibitors #MedicinalChemistry #DrugDiscovery

Characterization of the Formation of the Acyl Glucuronide Metabolite of 7-Carboxy-Cannabidiol in Human Liver, Kidney, and Intestinal Microsomes and In Vivo in Mice pubs.acs.org/doi/10.1021/... @acs.org #KellyChibale #DrugMetabolism #LiverToxicity #Pharmacokinetics #MedicinalChemistry #DrugSafety

AI-Assisted Discovery and Optimization of Small-Molecule TREM2 Agonists with Functional Microglial Activity pubs.acs.org/doi/10.1021/... @acs.org #KellyChibale #AlzheimersDisease #Neurodegeneration #AIDrugDiscovery #MedicinalChemistry #Neuroscience #DrugDiscovery

'Un-LOK-ing a New Approach for Conformational Selective Targeting of STK10 (LOK)' from ACS Medicinal Chemistry Letters is an open access #ACSEditorsChoice. 📖 Read the article: buff.ly/jVrjw4E @goetheuni.bsky.social @dkfz.bsky.social

For the 1-year anniversary of C2MCI’s International Research Network, today’s spotlight features Dr. Vinayak Singh & Dr. @kellychibale.bsky.social Working with Dr. Chantelle Capicciotti, this project is examining nanocluster-bacterial interactions + their potential against antimicrobial resistance.

The #GlobalFund partnership is fighting the deadliest infectious diseases in the most crisis-affected parts of the world. Through this partnership millions of lives have been saved. But there is still more work to do. HIV, TB & malaria have threatened humanity for far too long.

Zilurgisertib, a potent, selective ALK2 inhibitor, blocks aberrant signalling and prevents heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) models and is now advancing as a first-in-class, disease-modifying therapy @pubs.acs.org pubs.acs.org/doi/10.1021/... #KellyChibale

Epigenetic dysregulation drives hepatocellular carcinoma via G9a upregulation. In #ACSMedChemLett, Mu et al. report a novel & selective G9a inhibitor that lowers H3K9me2, restores tumour suppressor expression & outperforms sorafenib in models @pubs.acs.org pubs.acs.org/doi/10.1021/... #KellyChibale

New analogues of the Hsp90/Aha1 disruptor KU-177 reported by Catalfano et al. in #ACSMedChemLett reveal that a cis-amide linker is key for inhibition; a sulfonamide-containing compound showed strong efficacy, solubility & metabolic stability @pubs.acs.org pubs.acs.org/doi/10.1021/... #KellyChibale

(1/5) Our latest collaborative research project between @H3DCentre and @ersilia.io has recently been published in #NatCommun! Africa’s immense genetic diversity makes optimising drug treatments complex; this gap leads to limited pharmacogenetic data and suboptimal therapies for African populations.

Honoured to be named an @astmh.bsky.social Distinguished International Fellow and to deliver the Commemorative Lecture at the Closing Plenary in Toronto. Partnership across borders is vital to advancing global health innovation. 🔗 www.astmh.org #KellyChibale #ASTMH #GlobalHealth #TropicalMedicine

Delivered a seminar at @tsinghuauniversity.bsky.social University where next-gen antimalarials and shared insights from #ACSMedChemLett was discussed. My privilege to engage with global colleagues in science. 🔗https://www.acs.org/about.html #KellyChibale #MalariaResearch #DrugDiscovery

Attended the #GHDDI SAB meeting in Beijing (4–6 Nov), where members reviewed project progress and joined the Joint Steering Committee alongside #GatesFoundation and GHDDI leadership. Powerful partnerships continue to drive innovation in global health. 🔗 Read more: www.ghddi.org/en/about

(1/4) Over a decade in the making, the African Medicines Agency (AMA) has officially launched – a milestone for Africa’s public health and scientific sovereignty. The AMA aims to make drug regulation, research and discovery more relevant to African biology and the continent’s needs.

I have officially been inducted as an International Member of the US National Academy of Medicine. A proud moment for #AfricanLedScience and for the growing recognition of world-class research. www.kellychibale.co.za #KellyChibale #NAMMember #GlobalHealth #AfricaScience #DrugDiscovery

Proud to close the Science of Malaria Medicines Symposium in Geneva last week. Africa’s growing R&D capacity driving the next century of medicines. Full reflection www.linkedin.com/feed/update/... #KellyChibale #H3D #H3DFoundation #MedicinesforMalariaVenture #AfricaScience #MalariaResearch

'Discovery of Rogocekib (CTX-712): A Potent and Selective CLK Inhibitor for Cancer Treatment' from ACS Medicinal Chemistry Letters is currently free to read as an #ACSEditorsChoice. 📖 Read the article: buff.ly/3kE6tXf

Tuberculosis and its #AMR drug discovery challenges have the focus for today's second session at #GAMRIC2025. Talks from Kelly Chibale, Steve Berthel, Dirk Schnappinger, Bree Aldridge, and Jansy Sarathy. @carb-x.bsky.social @escmid.bsky.social @gardp.bsky.social

Reflections from Japan: Building Equitable Partnerships for #GlobalHealthInnovation www.linkedin.com/pulse/reflec... #AfricaInnovation #TICAD9 #H3D #H3DFoundation #GCADDA @gatesfoundation.bsky.social @billgates.bsky.social Keiko Tashiro Karen Makishima Trevor Mundel Peter Sands Eizo Takashima

In #ACSMedChemLett, Ichida et al. report diverse new S-trityl-L-cysteine derivatives as inhibitors of kinesin spindle protein (a promising cancer target), including feasibility studies as cytotoxic payloads for antibody-drug conjugates pubs.acs.org/doi/10.1021/...

The M1 receptor is a promising CNS drug target. In #ACSMedChemLett, Bungard et al. reveal an sp3-rich N-cyclopentyl pyrazole-based M1 positive allosteric modulator scaffold – a useful SAR starting point for structurally distinct chemotypes. pubs.acs.org/doi/10.1021/...

Recently reported in #ACSMedChemLett, Błauż et al. synthesised and investigated a series of ferrocenyl–cyclo-(Gly-L-Pro) hybrids which were shown to sensitise multidrug-resistant cancer cells to anticancer agents pubs.acs.org/doi/10.1021/... #CancerResearch #DrugResistance

In #ACSMedChemLett Liu et al. report a compound (VNRX-9945) with excellent antiviral activity against multiple #hepatitisBvirus genotypes in vitro, favourable PK profiles across multiple species, and efficacy in a mouse model of disease. pubs.acs.org/doi/10.1021/... #MedicinalChemistry #KellyChibale

We’re here until Monday at #ASMicrobe!  📍 Booth 2037 Our booth is a hub for advancements, showcasing our trailblazing authors’ solutions. Read it here: buff.ly/oTOO9pn

VanNatta et al. report in #ACSMedChemLett their SAR studies on potent colchicine site inhibitors of tubulin polymerisation. Efficacy studies of the corresponding prodrug salts demonstrated the potential of these analogues as cancer therapies. pubs.acs.org/doi/10.1021/...

In #ACSMedChemLett, Schlegel et al. report the synthesis and evaluation of gold(I)-N-heterocyclic carbene complexes as potential anticancer agents, representing the first example of a gold(I)-N-heterocyclic carbene complex inducing ferroptosis Full article here: pubs.acs.org/doi/10.1021/...

Introducing the potential binding interface between a TRAIL-mimicking peptide and DR5 via alanine scan. Tripathi et al. used experimental + in silico methods to learn how this 16-residue peptide binds to the death receptor DR5. pubs.acs.org/doi/10.1021/... #CancerResearch #ACSMedChemLett

I am excited to be speaking at the 10th annual African Diaspora Network Investment Symposium from 28-30 May 2025 at The George Washington University about Investment in Healthcare. Register bit.ly/ADIS25 #ADIS25 #BeyondRemittances #InvestInAfrica #AfricanDiaspora #Innovation #Entrepreneurship

Gastrin-releasing peptide receptor is a promising target for #cancer #radiotheranostics. In #ACSMedChemLett, Tsuchihashi et al. report a novel GRPR-targeted radioligand with favourable pharmacokinetics & a high-level accumulation in tumours. > pubs.acs.org/doi/10.1021/... #OncologyInnovation

Announcing Prof. David Heppner and Dr. Leslie Burnett as the presenters of our ‘Advancing bRo5 Chemical Matter to the Clinic and Exploring Novel Kinase Inhibitors’ webinar. 🗓️ Thursday, June 12 🕙 11:00 EST Register for free: buff.ly/AJMoaoB #ChemSky #ACSAdvancingbRo5

Honoured to be elected to the @theNASciences as one of 30 International Members in 2025. 🔗 www.nasonline.org/news/2025-na... #NAS2025 #DrugDiscovery #Science #GlobalHealth #UCTN

Targeting amino acids other than Cys, Ser & Thr is an emerging strategy in covalent probe design. This study by Doak et al. in #ACSMedChemLett describes the reaction between a novel allene warhead and a His residue in the E. coli DsbA enzyme. Read here: pubs.acs.org/doi/10.1021/... #DrugDiscovery

A new editorial explores the importance of publishing for industrial medicinal chemists. Read more in Journal of Medicinal Chemistry: buff.ly/CNAC2Qz

Proud to be part of this incredible momentum at H3D. Grateful for the partnerships and honoured by the recognition from Leiden University. Onward! www.linkedin.com/posts/drugdi...

To improve existing #molecularprobes based on TMTP1 (a #tumour-homing peptide), a cyclic TMTP1-based PET probe was designed, synthesised and evaluated for imaging hepatocellular #carcinoma in small #animalmodels, showing promise. pubs.acs.org/doi/10.1021/...

The oestrogen receptor β (ERβ) is a promising drug target for #tumoursuppression. In #ACSMedChemLett, Bucknam et al. describe the power of modern asymmetric de novo synthesis of estranes to identify potent and selective agonists of ERβ pubs.acs.org/doi/10.1021/...

I’m excited to join the Bluesky community and continue sharing my insights, have robust discussions and updates around my latest work. Looking forward to connecting and engaging with you all in this new space! Let’s build something great together.