Increased HCN1 activity in human excitatory neurons drives excessive network bursting in Dravet syndrome https://www.biorxiv.org/content/10.1101/2025.10.03.680281v1

I may be a little biased here but I think this is SUCH a cool story….a new HCN1-focussed mechanism in Dravet syndrome (infant epilepsy). Helps to explain why current treatments haven’t worked and offers a novel genuinely druggable target.Awesome 🤩🤩🤩 www.biorxiv.org/content/10.1...

1/10 Our latest research, led by Monika Moissidis, identifies a mechanism regulating the maturation of PV interneurons in the #cortex. This is the story @cellcellpress.bsky.social www.cell.com/cell/fulltex... ⬇︎ thread @devneuro.bsky.social @kingsioppn.bsky.social @wellcometrust.bsky.social

New paper from Julie Jézéquel and the Rico lab on role of cadherins in neuronal inhibition out now in Nat Comms! @natureportfolio.nature.com rdcu.be/el18f

1/10 Our latest research, led by @martijnselten.bsky.social, identifies a mechanism through which Parvalbumin (PV) interneurons regulate their activity in the #cortex. This is the story @nature.com www.nature.com/articles/s41... ⬇︎ 🧵 @devneuro.bsky.social @kingsioppn.bsky.social @erc.europa.eu

Deadline for FENS/IBRO-PERC stipends for our summer course extended to March 05, 2025‼️ EU students (outside Netherlands) can apply here for free course admission and 750 EUR travel funding 👉 loom.ly/yJqQ0rY For regular registration 👉https://lnkd.in/gQ_zXCWH

Ever wondered how to share research data but didn’t know where to start? Join us for an informal and open workshop where we’ll break down the how and why of data sharing.

Delighted to see this out! A great story by @bcompans and @vimast86 with the help of @Lenherr_C. Nanoscale plasticity of axo-axonic synapses at the AIS. Enjoy!