Diego U. Ferreiro
@diegulise.bsky.social
📤 35
📥 41
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Ciudad Univ. ARG. Vía lâctea.
reposted by
Diego U. Ferreiro
Ezequiel Galpern
7 days ago
Our method for predicting folding dynamics/mechanisms from sequence info is now a book chapter!
link.springer.com/book/9781071...
@diegulise.bsky.social
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Maybe
@sokrypton.org
and
@lindorfflarsen.bsky.social
find it usefull?
add a skeleton here at some point
3 months ago
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reposted by
Diego U. Ferreiro
Ezequiel Galpern
3 months ago
❗New Preprint w/ C Bueno (@cabb99.bsky.social), IE Sánchez (
@nachoquique.bsky.social
), PG Wolynes & DU Ferreiro (
@diegulise.bsky.social
) We define the Protein Dark Energy and use it to localize and quantify the functional evolutionary constraints on natural proteins
arxiv.org/abs/2508.08109
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Probing the Dark Energy in the Functional Protein Universe
We show how to localize and quantify the functional evolutionary constraints on natural proteins. The method compares the perturbations caused by local sequence variants to the energetics of the prote...
https://arxiv.org/abs/2508.08109
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reposted by
Diego U. Ferreiro
Nacho Sánchez
10 months ago
En ciencia no hay preguntas pequeñas, pero igualmente divierte investigar con
@diegulise.bsky.social
y Ezequiel Galpern por qué hay 20 aminoácidos en las proteínas y 4 nucleótidos en el ARN
doi.org/10.1590/SciE...
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Why are there 20 amino acids and 4 nucleotides?
Evolution of folded biopolymers requires effective and fast search of both the conformational space for folding and the sequence space for evolution. Molecular information theory and energy landscape theory show that the alphabet size of extant proteins and RNA is just enough to fulfill these requirements, given the constraints posed by the chemical physics of these polymers. Empirical estimations of the size of the effective sequence and conformational spaces of natural biopolymers support the theoretical predictions.
https://doi.org/10.1590/SciELOPreprints.11013
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