Diego U. Ferreiro
@diegulise.bsky.social
📤 35
📥 43
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Ciudad Univ. ARG. Vía lâctea.
reposted by
Diego U. Ferreiro
Ezequiel Galpern
about 2 months ago
Why are there 20 amino acids and 4 nucleotides? Combining Energy Landscape and Molecular Information theories provides constraints to the alphabet size of an evolving biopolymer, given its physico-chemical properties... Read more in our new article:
www.nature.com/articles/s41...
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An information-theoretic argument for the restriction of the current biological alphabets to 4 nucleotides and 20 amino acids - Scientific Reports
Life as we know it is based on foldable biopolymers encoded with just 4 nucleotides or 20 amino acids. Evolution of these biopolymers requires effective and fast search of both the conformational spac...
https://www.nature.com/articles/s41598-026-46009-8
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reposted by
Diego U. Ferreiro
Ezequiel Galpern
4 months ago
"Probing the Dark Energy in the Functional Protein Universe" is now published in
@pnas.org
🎉
www.pnas.org/doi/10.1073/...
add a skeleton here at some point
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reposted by
Diego U. Ferreiro
Ezequiel Galpern
6 months ago
Our method for predicting folding dynamics/mechanisms from sequence info is now a book chapter!
link.springer.com/book/9781071...
@diegulise.bsky.social
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Maybe
@sokrypton.org
and
@lindorfflarsen.bsky.social
find it usefull?
add a skeleton here at some point
9 months ago
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reposted by
Diego U. Ferreiro
Ezequiel Galpern
9 months ago
❗New Preprint w/ C Bueno (@cabb99.bsky.social), IE Sánchez (
@nachoquique.bsky.social
), PG Wolynes & DU Ferreiro (
@diegulise.bsky.social
) We define the Protein Dark Energy and use it to localize and quantify the functional evolutionary constraints on natural proteins
arxiv.org/abs/2508.08109
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Probing the Dark Energy in the Functional Protein Universe
We show how to localize and quantify the functional evolutionary constraints on natural proteins. The method compares the perturbations caused by local sequence variants to the energetics of the prote...
https://arxiv.org/abs/2508.08109
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reposted by
Diego U. Ferreiro
Nacho Sánchez
over 1 year ago
En ciencia no hay preguntas pequeñas, pero igualmente divierte investigar con
@diegulise.bsky.social
y Ezequiel Galpern por qué hay 20 aminoácidos en las proteínas y 4 nucleótidos en el ARN
doi.org/10.1590/SciE...
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Why are there 20 amino acids and 4 nucleotides?
Evolution of folded biopolymers requires effective and fast search of both the conformational space for folding and the sequence space for evolution. Molecular information theory and energy landscape theory show that the alphabet size of extant proteins and RNA is just enough to fulfill these requirements, given the constraints posed by the chemical physics of these polymers. Empirical estimations of the size of the effective sequence and conformational spaces of natural biopolymers support the theoretical predictions.
https://doi.org/10.1590/SciELOPreprints.11013
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