🚨 We discovered a new mode of Hox gene regulation in annelids! 🪱 A distal enhancer acts as a "global control region", lifting Hox genes from Polycomb repression. This is reminiscent of Hox gene control in vertebrates, but the two modes likely evolved convergently. www.biorxiv.org/content/10.6...

🦈🧠2 JOB OFFERS in the brand-new Neuroshark group starting at the Institute of Neuroscience Paris-Saclay (NeuroPSI)? Lab manager: www.linkedin.com/posts/idoia-... Bioinformatician: www.linkedin.com/posts/idoia-... Curious about the lab but not your profile? Feel free to contact me

This year, the annual symposium of my Chaire @college-de-france.fr will be on The Evolution of Developmental Mechanisms. An impressive lineup of speakers and weirds animals, including humans. Free entrance and coffee breaks. Come, have a seat, relax and enjoy the best possible basic science🤘RT🙏

Do you work with a strange model species and are frustrated by the lack of antibodies for immunos? Here's a web app that does some computational pre-screening for you. sixpack-abscan.serve.scilifelab.se

Capturing somatic mutations in single-cell probe-based assays (ie. 10X Flex) is a hard task, especially if you don't know *exactly* the mutations you want to capture, or if your target sequence is a mutational hotspot with many possible alternative alleles. Here's the way we pulled this off. Enjoy!

Last week I gave a talk on cell types at our monthly lunch seminar! 🫣 A mix of science outreach and philosophy of biology — what could possibly go wrong? 😄 Loved every minute, hope the audience did too!

Wonderful retreat of Cell and Dev Biol @cirbcdf.bsky.social @college-de-france.fr 👏👍 Great talks from young colleagues, lot of energy and good vibes🔥 (also karaoké, I heard) 🙏 organisers, you rock!

Vendredi prochain 6 mars à 10h, début de mon cours 2026 @college-de-france.fr. Les relations conflictuelles entre les variations de l’ADN et l’évolution des structures🤓 L’ADN; cause proximale ou cause ultime? 🤔 Entrée libre, sortie libre! Amis Parisiens, 🙏RT 🤘

I've started my own lab 🎉 PhD/postdoc positions available - reach out if curious about cerebellum evo-devo and autism spectrum disorders. We’re based at Uni Tartu, Institute of Genomics (home to Estonian Biobank), and funded by @simonsfoundation.org @embo.org, and the Estonian Research Council.

First retreat of our #DynaTrans @erc.europa.eu synergy consortium. Great science and interactions, (little) wine testing and (lots of-) Poisson distributions with the Gregor @pasteur.fr, Tkacik #ISTA and our @college-de-france.fr labs, in wonderful #Ermenonville castle🤘

Interested in understanding how new cell types evolve? Consider joining our group for a PhD!

How to represent genomes in 3D? In this paper (and video), we propose Geometric Diagrams of Genomes (GDG)—a visual grammar that aims at emulating the effect ribbon diagrams (Richardson et al 1981) had in protein structural biology. Time will tell.😅 👉🏼 genomebiology.biomedcentral.com/articles/10....

Are digits modified fins, or evolutionary innovations? Read how we tackled this old question from a new angle🧪 A story with @chasebolt.bsky.social, @homeobox.bsky.social and myself, coordinated by @denisduboule.bsky.social from @college-de-france.fr and published in @nature.com today! #InHoxWeTrust

We're looking for a PhD student! Join the team to develop new technologies for targeted spatial omics. More info and instruction on how to apply at the following link: su.varbi.com/what:job/job...

Such a great picture to announce that I am now postdoc in Denis Duboule's team at @college-de-france.fr 🥳🍾 Learning a lot about gene regulation and chromatin organization, lots of challenges ahead! What more could you ask for? Thank you for the opportunity @denisduboule.bsky.social 🤗

🧠🦈Excited to present our latest work🧠🦈Interested in brain evolution? And shark embryos? Then read on… Our work sheds light on the deep origins of our brain’s most complex regions.

We are hiring! ✨ Several predoc and postdoc open positions, check them here: www.achucarro.org/job-opportun...

TIL the original paper describing CRISPR, by Francisco Mojica, was rejected by 4 journals and took 2 years to be published

Our study on a male-essential microRNA and the evolution of other dosage compensation mechanisms in birds is now out in Nature! www.nature.com/articles/s41...

Excited to launch our AlphaGenome API goo.gle/3ZPUeFX along with the preprint goo.gle/45AkUyc describing and evaluating our latest DNA sequence model powering the API. Looking forward to seeing how scientists use it! @googledeepmind

Rigor and objectivity are essential in Science 🧪—but Science is also driven by creative humans, whose personalities reflect their unique perspectives and reasoning. This is a wonderful talk, and I couldn’t help but smile at each of Fer’s reflections! 🥳 Great human, better science 😎

We are delighted to share our new preprint “The evolution of gene regulatory programs controlling gonadal development in primates” www.biorxiv.org/content/10.1...

🎙️ Just out: my interview on The Creative Process podcast! A surprising conversation where we went way beyond the usual: cultural evolution, the language-psychology link, AI legislation and brain constraints, the beauty of dev biology… and creativity in research! 🧠✨ Listen here: shorturl.at/Sjqo7

The research team at the Atapuerca archaeological sites in Burgos, Spain, has just broken its own record by discovering, for the third time, the oldest human in Western Europe. 👇 @mmartinont.bsky.social in @mapignorance.bsky.social mappingignorance.org/2025/03/19/w...

Last Friday, I became a PhD! 💐 I could not be more thankful to my supervisor @PhyloBrain, the thesis committee @margaridamcm.bsky.social @AinaraCastellanos @JoseLuisFerrán and everyone who made possible this journey (colleagues @achucarro.bsky.social and collaborators @kaessmannlab.bsky.social ) 🥰

How does gene regulation shape brain evolution? Our new preprint dives into this question in the context of mammalian cerebellum development! rb.gy/dbcxjz Led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social

Last week, I successfully defended my PhD thesis Microglia Development: From Proliferative Progenitors to Functional Phagocytes, under the supervision of Amanda Sierra. I am deeply grateful to Amanda, my amazing labmates, and everyone in attendance for their incredible support! 🧠🔬

Extremely proud of @martapiglesias.bsky.social 🎉🎉 Huge amount of work carried out these four years, I am sure it will pay off ✈️ Congrats, new PhD in the house 🍾💐

Is there anyway of activating notifications? I really miss that feature from Twitter @bsky.app

This paper here is the product of one of my funniest collaboration ever. Developmental biology, evolution, tech development, memes, gifs, improvised brainstorming sessions via WhatsApp, and so much more... Crazy things can happen when people with different skill sets have fun together!

Just very happy to have our paper out today! A big thanks to all our co-authors, and to Nikolai and @steinaerts.bsky.social for the teamwork over the past years. If you are interested in using our models for cross-species enhancer studies, check out crested.readthedocs.io/en/stable/mo... 🙂

Our article on the evolution of pallial circuits is out www.science.org/doi/10.1126/... 🥳 Eneritz Rueda-Alaña & Fernando García-Moreno led this study that proves how similar adult pallial neurons are generated in different regions and timepoints. Evolutionary CONVERGENCE of neurons & circuits! 🦎🐤🐭

So excited to announce that our study on the development and evolution of pallial cell types and structures in birds, led by @bassi-z.bsky.social, is now out in @science.org! www.science.org/doi/10.1126/...

For my first post on 🦋, I am incredibly excited to share that my PhD paper has been published in #ScienceAdvances! We compared the development of the anterior neuroectoderm to uncover how the chordate #forebrain evolved 🧠. Have a look at the summary 🧵 below! www.science.org/doi/10.1126/...

🚨New Perspective on microglia pruning 🚨 Thrilled to share our latest publication, where we propose a novel framework to distinguish between two potential mechanisms of synapse elimination: culling and scavenging. Check it out and let us know what you think! 🔬🧠 www.nature.com/articles/s41...

It is a pity having lost all tweets about congresses, publications and many others... but let's start celebrating! 🎉🥳 Evolution and sport together in my 4th place on @fatapuerca.bsky.social Cross-Country Race! 😎 Suffering like a Homo antecessor 😅😅