Morgan Jones
@04mjone.bsky.social
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Structural biologist working to understand DNA replication at the MRC-LMB
Congrats to Jonas! Not satisfied with working only on replication, he’s bagged himself a paper on bacterial translation 🙃
www.nature.com/articles/s41...
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Structure of the 30S translation initiation complex coupled to paused RNA polymerase and its potential for riboregulation - Nature Communications
Small regulatory RNAs can act on target mRNAs to control their translation and stability. Here, the authors present evidence that this riboregulation can potentially regulate by pairing to a target si...
https://www.nature.com/articles/s41467-025-67330-2
4 days ago
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Morgan Jones
Fabai Wu
2 months ago
Glad to share our paper out today @NatureEcoEvo: “Serial innovations by Asgard archaea shaped the DNA replication machinery of the early eukaryotic ancestor”.
www.nature.com/articles/s41...
#microsky
#archaeasky
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Serial innovations by Asgard archaea shaped the DNA replication machinery of the early eukaryotic ancestor - Nature Ecology & Evolution
Phylogenetic and biochemical analyses show a diversity of components of the DNA replication machinery in different Asgard archaea that contributed to the eukaryotic DNA replication machinery.
https://www.nature.com/articles/s41559-025-02882-6
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Morgan Jones
Rob Klose
2 months ago
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost!
tinyurl.com/mr3m7bd3
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I’m really excited to share that I’ve been awarded a Wellcome Trust Career Development Award to start my own research group at Oxford University Biochemistry Department @BiochemOxford 🧬🎉
2 months ago
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Great new work from the very talented Emma Fletcher (@Yeeles_Lab). Biochemistry, and a touch of cryoEM, reveal why the DNA replication machinery needs a dedicated leading strand PCNA clamp loader. 🧬🧪🥼🔬🧑🔬
www.embopress.org/doi/full/10....
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Competition for the nascent leading strand shapes the requirements for PCNA loading in the replisome | The EMBO Journal
imageimageCtf18-RFC is a dedicated leading-strand replication clamp loader, with RFC unable to fulfil this role. This study provides a mechanistic basis as to why this is the case and reveals unique f...
https://www.embopress.org/doi/full/10.1038/s44318-025-00386-4
9 months ago
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