🍄 New study on #fungal #isocyanide synthases (#ICSs)! With @grantnickles.bsky.social @kellerlab.bsky.social (Uni. Wisconsin-Madison) @currentbiology.bsky.social @unipd.bsky.social Thanks all for the great teamwork! doi.org/10.1016/j.cub.…#Lichensns#SecondaryMetabolisms#biosyntheticGenese#fungigi

Anna Lehmann, PhD candidate working in the Heitman Lab, found Aspergillus fumigatus can briefly duplicate chromosomes to survive antifungal treatment, then revert without a trace. https://medschool.duke.edu/news/phd-candidate-discovers-hidden-way-fungal-pathogen-may-resist-treatment

Big surprise just out from our lab. Transcriptome from A. fumigatus conidiophore made at 50C is upregulated for MAT1-1. Why is this sexual master regulator up in asexual development? Maybe priming future progeny for survival? www.biorxiv.org/content/10.6...

Our paper is finally out in PLOS Genetics! Glad to share this work exploring new functions of the Sxi1/Sxi2 homeodomain proteins in Cryptococcus deneoformans. dx.plos.org/10.1371/jour...

Excited to share new work from Sarvesh Surve examining the gut microbiota of adults with CF using colonoscopy samples and a culturomics approach. We note continued depletion of Bacteroidota (which we noted in kids) & enrichment of aerobes in the mucosa of pwCF. pubmed.ncbi.nlm.nih.gov/41256617/

Excited to share our new preprint in collaboration with @kellerlab.bsky.social! We identified unstable aneuploidy in Aspergillus fumigatus and explore how aneuploidy-mediated transcriptional and metabolic changes influence antifungal resistance. www.biorxiv.org/content/10.1...

Extremely excited to present our latest preprint in which we mapped a thermoregulation network that governs virulence in a human fungal pathogen through genetic suppressors, TurboID proximity ligation assay, and functional regulation via domain-truncation alleles. www.biorxiv.org/content/10.1...

Thrilled to share that the final chapter of my PhD with @rokaslab.bsky.social is now out in @natcomms.nature.com 🎉 Read it to find out how population structure impacts pathogenicity in Aspergillus flavus, a fungus that infects humans 🧪 rdcu.be/eAToj

🚨 Fungi + viruses + mammalian lungs? Buckle up! Our new paper in @natmicrobiol.nature.com uncovers the story of a deadly fungus and its gnarly viral hitchhiker — and how this duo may change how we diagnose & treat fungal disease 🍄🫁🚨 doi.org/10.1038/s415... ⬇️