Coxiella & Leishmania both reside within a lysosome-like compartment in human cells, but appear to modulate the protease cohort in different ways. I’m pleased to share our latest story here, out this week in I&I: journals.asm.org/doi/10.1128/... @hayleyjnewton.bsky.social @lauraem-lab.bsky.social

Check out our latest paper from first author Allison Scott using a powerful enrichment strategy to enable transcriptional profiling of the early stages of a rickettsial infection

Thrilled to share our latest story from postdoc @sitbrandon.bsky.social! Using a functional genetic screen, he discovered an unexpected way that Rickettsia relies on the host to stabilize the Sca2 surface protein that drives pathogen motility and virulence.

#Legionella pumps 100s of effector proteins into host cells, including to #mitochondria. @drdstojanovski.bsky.social &co show that effector LpPIP is a tail-anchored protein of the MOM that recruits protein phosphatase 1 to modulate the host mitochondrial P-proteome @plosbiology.org 🧪 plos.io/4f2T5kE

Excited to share this story from my PhD, out today in Nature Communications! We show that Coxiella removes cathepsin B to reduce lysosomal hostility and promote bacterial success. This depends on a vacuole established by effector CvpB. www.nature.com/articles/s41...