If chains are a fundamental organizational principle of cortex, how have we never noticed them before? The answer is that we are used to looking at data averaged across large groups, and group averaging hides them!

Thanks to @beckmanillinois.bsky.social for a nice write up on our work: beckman.illinois.edu/news/article...

(1/5) Our paper is out now in Neuron! bsky.app/profile/cp-n... The LPFC has fine-scale organization that gets missed in group-averaged data because of inter-individual variability. It is visible in individuals in both resting-state and task data.

Very excited about this project, led by @zachladwig.bsky.social We show that an individual’s lateral prefrontal cortex has reliable and highly detailed network organization missed in past group approaches. Full🧵 coming soon!

Individuals’ catenation maps were very similar. They all had dense catenation in prefrontal cortex, and moderate catenation in temporal, parietal, and insular cortex. Catenation was lowest in primary cortex and in parietal regions.

I always assumed that brain function had to line up with cytoarchitectonics. It turns out I was wrong. Human cortex, especially PFC, is tiled by chains of functional patches that subdivide and interlink architectonic areas into parallel processing streams. www.biorxiv.org/content/10.6...