🚀New preprint w/ @roberto_amv: We used chemogenetics to precisely control mitochondrial H2O2 in skeletal muscle in vivo. This exposes a dose-dependent sequence: translation suppression → proteolysis → denervation-like → degeneration @tejensen23 www.biorxiv.org/content/10.1...

Thrilled to share our new study (as a preprint) from the @tejensen23 lab showing, for the first time, that mitochondrial H₂O₂ is sufficient to trigger muscle wasting signatures and suppress protein synthesis. Huge thanks to @MuscleBiology and everyone involved! www.biorxiv.org/content/10.1...

Chemogenetic Mitochondrial H2O2 Generation Triggers Dose-Dependent Skeletal Muscle Wasting Signatures https://www.biorxiv.org/content/10.1101/2025.08.19.671046v1

Our new FASEBJ paper. We looked into mTOR Ser1261 phosphorylation in human and mouse muscle, proposed by Diane Fingar's lab to be first an Akt and then AMPK site regulating mTORC1 and 2 activity. Clearly AMPK site but impact on mTORC unclear in our hands faseb.onlinelibrary.wiley.com/doi/10.1096/...

Happy to share our latest publication with the Thomas Jensen team, featured in Free Radical Biology and Medicine last October www.sciencedirect.com/science/arti...