Our latest research pre-print on BioRxiv: Multi‑omic and spatial analysis reveals tumor‑derived paracrine signals drive suppressive macrophage polarization via activation of the cAMP-CREB axis in glioblastoma www.biorxiv.org/content/10.6...

Spatial organization of the TME explored using #spatialbiology. Neoplastic cell signaling and TME complexity are not only dependent on cell intrinsic genetics, but also dependent on cell density & stromal interaction. #cellsignaling #microenvironment #brain #GBM

ONLINE NOW: Special Issue on Radiation, Humanity, and Hope: 80 Years of Cancer Research Post-Hiroshima and Nagasaki academic.oup.com/carcin/issue...

Eighty years of cancer research after the atomic bombings of Hiroshima and Nagasaki doi.org/10.1093/carc...

Nobel laureate, molecular biologist & cancer researcher, David Baltimore, died at he age of 87. shorturl.at/2t7Ya In 1975, he shared the Nobel Prize in Physiology or Medicine for discovering reverse transcriptase, challenging the view that genetic information was only transferred from DNA to RNA

Radiation, Humanity, and Hope: 80 Years of Cancer Research Post-Hiroshima & Nagasaki In September, Carcinogenesis will publish a special issue to commemorate the 80th anniversary of the atomic bombings in Japan, & our understanding of radiation & its impact on human health academic.oup.com/carcin

Delighted to present our research at the #Spatial Imaging Workshop, hosted by Biological Optical Microscopy Platform (BOMP) @ The University of Melbourne & supported by Leica Microsystems & Light Microscopy Australia. The multiplex IHC image shows cell signaling activity using phospho-Abs in #GBM

The Who's Who of spatial biology in Australia & SE Asia at the WEHI Spatial Technology Symposium in Melbourne. A fabulous lineup of speakers & platform leaders highlighting the fast moving research & tech in #spatial #biology

I’m delighted to join the Cure Brain Cancer Foundation Scientific Advisory Committee & look forward to working with the CBCF, consumer advocates & researchers, to advance our understanding of the mechanisms underpinning brain cancer, to ultimately help patients and their families.

Multiomics Blueprint of Extreme Human Lifespan: “The picture…emerges…that extremely advanced age & poor health are not intrinsically linked & that both processes can be distinguished & dissected at the molecular level” Santos-Pujol et al., doi.org/10.1101/2025...

🚀 New publication! We developed a PTPRZ1-specific TCR-T cell therapy for glioblastoma. 🔬 Key findings: ✅ Identified a PTPRZ1-reactive TCR from a vaccinated patient ✅ Kills glioblastoma cells with no off-target effects ✅ Eliminates tumors in murine brain models 🔗 www.nature.com/articles/s41...

The University of Melbourne, Brownless Biomedical Library this morning & as it was: For me, it was the place to leaf through the latest hardcopy journal issues on the display stands, or search the journal archives for that elusive article required for my thesis

#GBM #TME #spatial analysis: incredible #cellsignaling heterogeneity at single cell resolution, predicts cell function. Differential PI3K-MAPK-CREB pathway activation/co-activation correlates with proliferation, cell density, angiogenesis & proximity to ECM-rich stroma: see go.unimelb.edu.au/52z8

While updating my CV for another grant application, I am yet again amused by the title of our review article (PDF version), from 2011 (the title is correct on PubMed & the journal web site). I never followed up to fix this because it's great as it i; at the cutting edge of science & mythology:

Bilingualism is associated with a bigger brain. Similar to other cognitively demanding skills, it leads to dynamic subcortical structural adaptations which can be nonlinear, in line with expansion-renormalisation models of experience-dependent neuroplasticity. www.nature.com/articles/s41...

Great story; Gliomagenesis mimics an injury response orchestrated by neural crest-like cells www.nature.com/articles/s41...

Fascinating study!

Merry Christmas! Καλά Χριστούγεννα! Frohe Weihnachten!

Unraveling the functional complexity of the tumor microenvironment via #spatialbiology. The 2 images show rGBM tissue with cell signaling cell plot (left) & cell-type mIHC (right). Neoplastic, vascular & immune cells show distinct signals which correlate with cell clustering & proximity to ECM

In Carcinogenesis: shorturl.at/6pvy6 Male mice with nestin-targeted PI3K & PTEN mutations develop tumors which resemble an aggressive form of sex cord stromal tumors. We describe the cell-of-origin, the complex histopathology & using #spatialbiology, the immune cell infiltration of this rare cancer

Well done Samuel! Last week, Samuel Widodo submitted his PhD thesis: "Signalling and Transcriptional Regulation of Tumour Associated Macrophage Polarisation in Brain Cancer" @UniMelb & has published 12 papers, so far, with some shown here. #glioblastoma #GBM #spatialbiology #OMICS #macrophages

Amazing: 3D organ-wide spatial analysis. (Almost) all of it: real-time methods for 4D analysis next? www.science.org/doi/10.1126/...

Mice with an inducible nestin-CreER transgene targeting PI3K & PTEN develop aggressive brain tumors doi.org/10.1093/neuo... ~20% of the mice also show tumours affecting the reproductive organs. Using #spatialbiology we describe the testis tumors, in the bioRxiv pre-print: doi.org/10.1101/2024...

To learn about #braincancer & the innovative use of mIHC #spatialbiology tech to understand key molecular & cellular mechanisms regulating the #tumormicroenvironment, go to: shorturl.at/Nafcw #GBM #brain #cancer

1st Bsky post pushed from you know where - Following several presentations on how we use #spatialbiology to investigate the #immunology of #braincancer - also see our recent review on this topic shorturl.at/7pwV1