Eighty years of cancer research after the atomic bombings of Hiroshima and Nagasaki doi.org/10.1093/carc...

ONLINE NOW: Special Issue on Radiation, Humanity, and Hope: 80 Years of Cancer Research Post-Hiroshima and Nagasaki academic.oup.com/carcin/issue...

Almonertinib enhances radiosensitivity in EGFR-mutant NSCLC via inhibition of EGFR signaling and DNA damage repair doi.org/10.1093/carc...

The Oncogenic Role of Aurora kinase A in Gastric Cancer: Mechanisms, Pathways and Clinical Relevance doi.org/10.1093/carc...

Epithelial Ikkβ deletion modulates immune responses and the IFNγ/CXCL9 axis during early esophageal carcinogenesis doi.org/10.1093/carc...

Nobel laureate, molecular biologist & cancer researcher, David Baltimore, died at he age of 87. shorturl.at/2t7Ya In 1975, he shared the Nobel Prize in Physiology or Medicine for discovering reverse transcriptase, challenging the view that genetic information was only transferred from DNA to RNA

Δ133-p53 isoform enhances TLR4 function to promote tumour growth doi.org/10.1093/carc...

Mammary Adipose Dysfunction in the Dual Epidemic of Obesity and Breast Cancer doi.org/10.1093/carc...

Radiation, Humanity, and Hope: 80 Years of Cancer Research Post-Hiroshima & Nagasaki In September, Carcinogenesis will publish a special issue to commemorate the 80th anniversary of the atomic bombings in Japan, & our understanding of radiation & its impact on human health academic.oup.com/carcin

Longitudinal single-cell RNA model aids prediction of EGFR-TKI resistance doi.org/10.1093/carc... The article finds that the molecular mechanisms driving EGFR-TKI resistance in lung cancer may also contribute to poorer prognosis, particularly in lung adenocarcinomas with high EGFR mutation rates.

Human papillomavirus (HPV) DNA methylation changes in HPV-associated head and neck cancer doi.org/10.1093/carc...

Interplay between inflammasomes and PD-1/PD-L1 and their implications in cancer doi.org/10.1093/carc...

Urinary Metabolites in Association with Kidney Cancer Risk academic.oup.com/carcin/advan...

The impact of reproductive factors on breast tumor and normal-adjacent tissue immune profile from menarche to menopause doi.org/10.1093/carc...

Somatic p53 mutations overrepresented in lung cancer confer resistance to ROS-induced cell death doi.org/10.1093/carc...

This study investigated race-specific epigenetic differences in endometrial cancer characteristics & identified subtype-associated CpG differences in genes, including genes regulating cytokine signaling, which were associated with race. doi.org/10.1093/carc...

B vitamins and colorectal cancer: exploring research hotspots and frontiers - a bibliometric and visual analysis (1994-2024) doi.org/10.1093/carc...

Genetic determinants & clinical significance of circulating and tumor-specific levels of insulin-like growth factor binding protein 7 in a Swedish breast cancer cohort: doi.org/10.1093/carc... Circulating & genetically predicted IGFBP7 levels are independent prognostic biomarkers in breast cancer.

ECM Remodeling & Malignant progression of Gallbladder Cancer doi.org/10.1093/carc... #ECM #gallbladder #cancer #bioinformatics

Genetic Susceptibility in Lung Squamous Cell Carcinoma: Data from 3890 LUSC cases and 13328 controls identified an association between 9q33.2 variants and increased risk of LUSC in smokers: doi.org/10.1093/carc... #lungcancer #LUSC #cancer #genetics #smoking

Multifaceted role of transgelin isoforms in cancer hallmarks Transgelins regulate actin filament stability & are implicated in carcinogenesis and chemoresistance. This review discusses transgelins as potential cancer biomarkers & oncogenic regulators. doi.org/10.1093/carc...

The Influence of Homologous Recombination Repair (HRR) on Temozolomide Chemosensitivity in Glioma. doi.org/10.1093/carc... This review discusses the role of HRR in temozolomide resistance in glioma, focusing on key HRR factors, including RAD51, ATM & ATR.

Amlodipine, an L-type Ca2+ channel inhibitor, regulates release of extracellular vesicles from tumor cells & emerges as a potentially promising drug to enhance immunotherapy by inhibiting the production of tumour-derived immunosuppressive exosomes doi.org/10.1093/carc...

A recent Japanese genome-wide association study identified 5 loci associated with the number of cigarettes smoked per day. This study evaluated whether these loci are associated with lung cancer risk directly or indirectly, through changing smoking behavior: doi.org/10.1093/carc...

In Carcinogenesis: shorturl.at/6pvy6 Male mice with nestin-targeted PI3K & PTEN mutations develop tumors which resemble an aggressive form of sex cord stromal tumors. We describe the cell-of-origin, the complex histopathology & using #spatialbiology, the immune cell infiltration of this rare cancer

Germline EPHB4R91H mutation as a key player in multiple primary lung tumors doi.org/10.1093/carc...

The current landscape of therapies for hepatocellular carcinoma: doi.org/10.1093/carc... Primary liver cancer is the third leading cause of cancer-related deaths, accounting for 8.3% of deaths among all cancers. This review discusses the current treatments for early, intermediate, and advanced HCC.

Surgical stress induced tumor immune suppressive environment: doi.org/10.1093/carc...

Antibody–drug conjugates (ADCs) in breast cancer: ADCs have made an impact on the treatment of breast cancer. This review summarizes the advances in ADCs in breast cancer patients and explores the challenges and future directions in this field. doi.org/10.1093/carc...

Dear Colleagues The journal Carcinogenesis has released a special issue on #PancreaticCancer research in honor of Perwez Hussain. It contains several open access reviews and Perwez’s last article. Please read and share. He is deeply missed. academic.oup.com/carcin/issue...

Special issue on the latest advances and challenges in pancreatic cancer research in memory of S. Perwez Hussain academic.oup.com/carcin/issue... including: CAFomics: convergence to translation for precision stroma approaches

Allura Red AC is a xenobiotic. Is it also a carcinogen? doi.org/10.1093/carc...

Carcinogenesis will be publishing a special issue on “Radiation, Humanity, and Hope: 80 Years of Cancer Research Post-Hiroshima and Nagasaki” in the third quarter issue of its 2025 volume 46. academic.oup.com/carcin/pages...

Publishing outstanding reviews and research articles. Co-founded by Colin Garner and Anthony Dipple in 1980 ‘to encourage cross-fertilization of ideas and provide a primary literature source for the latest developments’ in: Cancer Mechanisms | Genetics | Immunology | Translation | Epidemiology