”Protein aggregation as pathomechanism and biological stratification of schizophrenia subsets” Invited lecture at King’s College on March 10th, 2026 (thanks Anthony Vernon!) Link youtube.com/watch?v=SO8r... Renaming schizophrenia: yes! – but by its biologically defined subsets!

”Protein aggregation as pathomechanism and biological stratification of schizophrenia subsets” Invited lecture at King’s College on March 10th, 2026 (thanks Anthony Vernon!) Link youtube.com/watch?v=SO8r... Renaming schizophrenia: yes! – but by its biologically defined subsets!

What does aging-associated brain lipofuscin consist of? Could this accumulating mass impair neuronal function and contribute to neuronal aging? In situ identified proteins from human brain lipofuscin by proteomics Among top hits PPT1 linked to genetic childhood lipofuscinoses shorturl.at/ih7Cn

"This work establishes a versatile platform for concurrent biosynthesis and diversification of psychoactive indolethylamines, paving the way for their production in plants." www.science.org/doi/10.1126/...

Molecular Precision Psychiatry. How schizophrenia subset identification leads to a tailored animal model, biomarkers and precise pharmacotherapy www.nature.com/articles/s41...

Molecular Precision Psychiatry. How schizophrenia subset identification leads to a tailored animal model, biomarkers and precise pharmacotherapy www.nature.com/articles/s41...

"our precision psychiatry approach: the biological definition of a subset of schizophrenia by identifying DISC1 protein aggregates, the generation of a corresponding animal model and a successful pharmacotherapy of a clinically relevant phenotype" www.nature.com/articles/s41...

"our precision psychiatry approach: the biological definition of a subset of schizophrenia by identifying DISC1 protein aggregates, the generation of a corresponding animal model and a successful pharmacotherapy of a clinically relevant phenotype" www.nature.com/articles/s41...

Oxidized MIF is an Alzheimer’s disease drug target relaying external risk factors to tau pathology cell.com/cell-reports...

Oxidized MIF is an Alzheimer’s disease drug target relaying external risk factors to tau pathology cell.com/cell-reports...

Alzforum: Phospho-Tau Might Take Down Viruses - But how does HSV-1 elicit increased tau phosphorylation and aggregation? alzforum.org/news/researc...

Potent novel anti-Herpes Simplex Virus 1 drug: • Effective in human brain organoids • Targeting macrophage migration inhibitory factor (MIF) • Rescuing viral cytotoxicity and induced tau protein pathology in vitro and in vivo www.cell.com/cell-reports...

Potent novel anti-Herpes Simplex Virus 1 drug: • Effective in human brain organoids • Targeting macrophage migration inhibitory factor (MIF) • Rescuing viral cytotoxicity and induced tau protein pathology in vitro and in vivo www.cell.com/cell-reports...

Veröffentlichung in Cell Reports Medicine: Besseres Verständnis von Alzheimer-Risikofaktoren Forschenden der Heinrich-Heine-Universität Düsseldorf (HHU) und des Universitätsklinikums Düsseldorf (UKD) ist es erstmals gelungen nachzuweisen, ... weiterlesen

Online now: Oxidized MIF is an Alzheimer’s disease drug target relaying external risk factors to tau pathology

Protein aggregates are analogous to the wreckage after a car crash at an unmarked intersection. Placement of a stop sign is more effective than calling more tow trucks. Antibodies clean up the wreckage, but do not prevent future car crashes. This installs🛑https://shorturl.at/RtKWK

Protein aggregates are analogous to the wreckage after a car crash at an unmarked intersection. Placement of a stop sign is more effective than calling more tow trucks. Antibodies clean up the wreckage, but do not prevent future car crashes. This installs🛑https://shorturl.at/RtKWK

"OxMIF participates in a host-viral interface connecting HSV-1 infection, and possibly other external stressors, with tau cellular pathology" Oxidized MIF is an Alzheimer’s disease drug target relaying external risk factors to tau pathology: Cell Reports Medicine www.cell.com/cell-reports...

"OxMIF participates in a host-viral interface connecting HSV-1 infection, and possibly other external stressors, with tau cellular pathology" Oxidized MIF is an Alzheimer’s disease drug target relaying external risk factors to tau pathology: Cell Reports Medicine www.cell.com/cell-reports...

Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks: Cell www.cell.com/cell/fulltex...

"These results highlight the increasing synchronization between gut microbiota rhythmicity and sleep-wake cycles during infancy,..." www.nature.com/articles/s41...

New today in @Nature: your visual cortex contains touch-based body maps. bit.ly/VisualBodyMaps Your brain transforms what you see into first-person, body-referenced codes: A previously unknown bridge between vision and touch.

"we present an in situ proteome analysis of age-associated human brain lipofuscin that ... reveals PPT1 protein as one major constituent ...It remains to be demonstrated whether PPT1's ... sequestration to lipofuscin leads to ... functional impairments" onlinelibrary.wiley.com/doi/10.1111/...

@sfnjournals.bsky.social , @hhu.de , @ckorth.bsky.social , @socforneuroecon.bsky.social , @sfn.org , @decisionneurop.bsky.social #neuroscience #schizophrenia #sociallearning #social #socialneuroscience #neuroeconomics doi.org/10.1523/JNEU...

Our paper is out: "Palmitoyl-Protein Thioesterase 1 (PPT1) Protein, Linked to Neuronal Ceroid Lipofuscinosis 1, Is a Major Constituent of Ageing-Related Human Neuronal Lipofuscin" where we identify the proteome of human brain hippocampal lipofuscin onlinelibrary.wiley.com/doi/10.1111/...

Our paper is out: "Palmitoyl-Protein Thioesterase 1 (PPT1) Protein, Linked to Neuronal Ceroid Lipofuscinosis 1, Is a Major Constituent of Ageing-Related Human Neuronal Lipofuscin" where we identify the proteome of human brain hippocampal lipofuscin onlinelibrary.wiley.com/doi/10.1111/...

Our paper is out: "Palmitoyl-Protein Thioesterase 1 (PPT1) Protein, Linked to Neuronal Ceroid Lipofuscinosis 1, Is a Major Constituent of Ageing-Related Human Neuronal Lipofuscin" where we identify the proteome of human hippocampus lipofuscin onlinelibrary.wiley.com/doi/10.1111/...

Disruption to the gut microbiome by non-antibiotics is linked to infection risk: Cell Chemical Biology www.cell.com/cell-chemica...

JCI Insight - Human pegivirus alters brain and blood immune and transcriptomic profiles of patients with Parkinson’s disease insight.jci.org/articles/vie...

our paper is out: "social impairments may stem from a fine-grained circuit-selective dysfunction rather than generalized reward processing deficit. The tgDISC1 rat is a translational platform for probing the neural substrates of social dysfunction in psych. dis." www.jneurosci.org/content/earl...

our paper is out: "social impairments may stem from a fine-grained circuit-selective dysfunction rather than generalized reward processing deficit. The tgDISC1 rat is a translational platform for probing the neural substrates of social dysfunction in psych. dis." www.jneurosci.org/content/earl...

Proximity to Golf Courses and Risk of Parkinson Disease url:https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2833716?utm_source=bluesky&utm_campaign=content-shareicons&utm_content=article_engagement&utm_medium=social&utm_term=090525

Our results are consistent with previous studies and provide clues regarding the contribution of viruses to the pathology of psychiatric disorders."" www.nature.com/articles/s41...

Thalamus and consciousness: a systematic review on thalamic nuclei associated with consciousness www.frontiersin.org/journals/neu...

"Sleep, like ageing17,18, may be an inescapable consequence of aerobic metabolism" www.nature.com/articles/s41...

SARS-CoV-2 induces Alzheimer’s disease–related amyloid-β pathology in ex vivo human retinal explants and retinal organoids | Science Advances www.science.org/doi/10.1126/...

„Research Trek – Aufbruch in ein unbekanntes Wissenschaftssystem“ dirnagl.com/2025/06/17/r...

"We provide the first experimental evidence that psilocin (the active metabolite of psilocybin) treatment extends cellular lifespan and psilocybin treatment promotes increased longevity in aged mice, suggesting that psilocybin may be a potent geroprotective agent." www.nature.com/articles/s41...

Please visit my poster July 9th 4:30 pm at the upcoming @assc28.bsky.social : "Content consciousness as an acquired cognition entangled with tool evolution" basically. presenting my recent paper "Tool evolution as a prerequisite for consciousness" shorturl.at/ATzwD -looking forward for discussions!

Event structure sculpts neural population dynamics in the lateral entorhinal cortex | Science www.science.org/doi/10.1126/...