🌪️ Evolution's sledgehammer approach: Instead of surgical genome changes, #Yeast under multiple selection pressures unleashes chromosome-wide instability. Cell cycle breakdown creates reversible aneuploidy spanning many chromosomes 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

Is this thing still on? Anyway, we have a new preprint out of a story that's been brewing in my lab for several years and is finally ready to see the light of day. It's about what happens to Candida glabrata while it's hanging out inside macrophages.

The preprint for our super fun collaboration with Erika Shor @mutant-fungus.bsky.social is out. Check it out to see some really beautiful PFGE karyotyping gels from Candida glabrata!

📢 New paper out in Mol Syst Biol! During the development of WT yeast colonies, small cell subpopulations experience transient, high-intensity mutational bursts. Such hypermutation episodes are modulated by the DNA damage tolerance pathway 🧬 🔗 www.embopress.org/doi/full/10....

Quote post with a picture you took in a National Park. Aurora Borealis at Yellowstone National Park, seen from my campsite at Slough Creek Campground, October 11 2024, 1:37AM MDT.

8/8. So, if you’re feeling down about these attacks, I understand—I feel that way too. But just remember that they’re not attacking because your work doesn’t matter; they’re attacking *precisely* because it does. So, get some rest, connect with your people, and keep doing it.

Delighted to publish my new molecular animation: DNA Break Repair by Homologous Recombination youtu.be/Xe-83tBcxhs

Happy US Thanksgiving Day!