New multicohort resource for researchers exploring proteomics in neurodegenerative diseases — including data from the Whitehall II study. 🧠🔬 www.nature.com/articles/s41...

It was a pleasure to celebrate Whitehall II's 40th anniversary this month at UCL with Professor Sir Michael Marmot who set up the study in 1985. Watch the recording of the event here: www.youtube.com/watch?v=__gL...

Workplaces are an important but underused channel for health promotion – a new review examines the most effective strategies. www.thelancet.com/journals/lan...

2 new studies on weight loss 1. Sustained reduction during midlife improved survival and reduced chronic diseases jamanetwork.com/journals/jam... 2. A randomized trial found patient-to-patient care was more effective than professional for weight loss and less CV risk jamanetwork.com/journals/jam...

Long-term follow-up shows that losing weight in midlife—without surgery or medication—can lower the risk of chronic diseases later in life jamanetwork.com/journals/jam...

My conversation with Sir John Bell, one of the most influential physician-scientists in the world. (it's free, with transcript) erictopol.substack.com/p/sir-john-b...

A state-of-the-art review with 1700+ references unpacks how systemic factors shape brain and vascular ageing—drawing on parabiosis, blood exchange and plasma transfer studies. link.springer.com/content/pdf/...

A 10-year gap in frailty-free life expectancy between the highest and lowest socioeconomic groups. link.springer.com/article/10.1...

Multiple recent studies, including 3 impressive natural experiments, consistently show a link between Shingles vaccines and reduced dementia. This week a nationwide S Korea study added a reduction of cardiovascular events My summary Table. More here on dementia erictopol.substack.com/p/the-shingl...

Things with evidence that promote healthy aging, and I've adopted gift link www.wsj.com/health/welln...

Reducing high blood pressure substantially lowers the risk of dementia and cognitive impairment without dementia, according to the results of a clinical trial published in Nature Medicine. go.nature.com/44z6kGy #medsky 🧪

A study in Nature Medicine shows that a meta-prediction framework integrating polygenic risk scores spanning multiple conditions and nongenetic factors had superior performance in predicting the 10-year risk of coronary artery disease. go.nature.com/4igXqAJ 🔒

The future burden of dementia in the US may be substantially lower than current projections. Watch and learn more, then read the full JAMA Viewpoint on the changing story of the dementia epidemic. jamanetwork.com/journals/jam...

In case you follow me @X, my account was HACKED and someone is impersonating me selling bitcoin (and who knows what else to come). Beyond that, all attempts to contact X to rectify the matter go nowhere. If you have an account there, and get the chance, please post so people will know. Thanks!

Do viruses play a role in the cause of Alzheimer's disease? In the wake of observational studies showing some protection from the vaccines vs. shingles www.economist.com/science-and-... Unclear, but an ongoing clinical trial of valacyclovir, an anti-viral, may help to resolve

We've known social disadvantage was linked to adverse health outcomes. A @NatureMedicine study used high- throughput proteomics to show there is accelerated aging, increased risk of 66 age-related diseases, and unfavorable changes in the immune system, ⬆️ inflammation www.nature.com/articles/s41...

This multicohort study links social disadvantage to accelerated ageing, highlighting NF-κB activation as a key underlying mechanism. #Aging #SocialDeterminants #NFkB rdcu.be/edyqo

New study on excess deaths during the COVID-19 pandemic across 18 European countries 
–Countries with lower GDP saw a greater loss of years of life
 –Higher vaccination coverage was linked to fewer years of life lost—independent of GDP #PublicHealth #Vaccination journals.plos.org/plosmedicine...

The person-years of life lost from the pandemic (here for Europe) with premature mortality reflects an underestimate of the toll of Covid @plos.org journals.plos.org/plosmedicine...

🔬Our latest research published in the Lancet Digital Health shows that different organs age at different rates, and that accelerated biological ageing is linked to a higher risk of age-related diseases—including multimorbidity across multiple organs. www.thelancet.com/journals/lan...

Protein organ clocks, as assessed in over 6,000 people (~4,000 plasma proteins, 8 organs) with 20-year follow-up are predictive for over 30 age-related diseases www.thelancet.com/journals/lan...

Our lifestyle and environmental exposures are the predominant influencers of healthy aging and premature mortality, compared with polygenic risk, in the first comprehensive assessment www.nature.com/articles/s41... open-access

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Worth reposting!

Engaging in leisure-time physical activity adds 1–2 extra disease-free years, with greater benefits among smokers, those with social disadvantage, and individuals with depression. 💡 Boosting physical activity may reduce health disparities. Read more: www.thelancet.com/journals/lan...

Pathophysiology of clinical obesity

Redefining obesity, report of a new commission, to override current BMI categories and better define features and pathophysiologic consequences of pre-clinical and clinical obesity www.thelancet.com/journals/lan... open-access

We have very limited means of tracking inflammation in the body, like a one-off hs-CRP blood test. Today @science.org Continuous real-time monitoring of inflammation and protein biomarkers in the body with a shaking sensor science.org/doi/10.1126/...