Ole Christian Sylte
@olechsylte.bsky.social
📤 126
📥 154
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Neuroscientist, postdoc in Stephenson-Jones lab at Sainsbury Wellcome Centre, UCL
pinned post!
Stable maps from drifting neurons: CA1 solves the "representational drift paradox" through coordinated population dynamics. New preprint w/
@antjekilias.bsky.social
, Marlene Bartos and
@jf-sauer.bsky.social
showing that representational drift isn’t random—it’s structured to preserve information🧵👇
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Coordinated representational drift supports stable place coding in hippocampal CA1
The phenomenon of representational drift (i.e., changing neuronal tuning during repeated exposure to the same stimuli), is a fundamental paradox in neuroscience that raises the question how stable beh...
https://www.biorxiv.org/content/10.1101/2025.02.04.636428v1
8 months ago
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Ole Christian Sylte
Gatsby Computational Neuroscience Unit
9 days ago
🙋Are you interested in bridging theory & experiments? Applications are now open for 2026 entry to the Gatsby Unit & SWC joint PhD programme. Join us and be part of a vibrant research community! 💰 Fully-funded 4-year programme ℹ️
www.ucl.ac.uk/life-science...
@sainsburywellcome.bsky.social
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Ole Christian Sylte
Sainsbury Wellcome Centre
11 days ago
Applications are now open for the SWC Systems Neuroscience PhD Programme. Join us in London! 🧠 World-class neuroscience training 💰 Fully-funded 4-year programme 🖥️ Close links to
@gatsbyucl.bsky.social
Apply by 3 Nov:
www.sainsburywellcome.org/web/content/...
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Ole Christian Sylte
Eelke Snoeren
about 2 months ago
🚨New paper alert! We studied the long-term consequences of SSRI use during pregnancy on the offspring in rats in a seminatural environment. We found that perinatal FLX exposure significantly increases sexual behavior in adult male rats.
@uitnorgesarktiske.bsky.social
#neuroscience
#neuroskyence
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Perinatal fluoxetine exposure increases male rat sexual behavior
Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed to pregnant women due to their efficacy and safety profile, leading to potenti…
https://www.sciencedirect.com/science/article/pii/S0028390825003430?via%3Dihub
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Ole Christian Sylte
Jens-Bastian Eppler
2 months ago
And for me the big question is: What about representational drift? 😄 Manifolds can be mapped, but individual neuronal responses change. That’s neat, but how does it make sense? How can perception stay stable if the neurons keep changing? I’m sure manifolds will help us understand that too… 🧠🧪 3/3
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Ole Christian Sylte
Eelke Snoeren
3 months ago
🚨 New Article Alert! 🚨 Our latest research reveals how long-term consumption of a cafeteria (CAF) diet impacts the ventral tegmental area in rats. 🍔🍟🍩#Neuroskyence
@uitnorgesarktiske.bsky.social
www.sciencedirect.com/science/arti...
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Behavioral and neural alterations of the ventral tegmental area by exposure to junk food in rats
The brain reward system is essential for regulating appetitive and consummatory behaviors in response to various incentive stimuli. Junk food, charact…
https://www.sciencedirect.com/science/article/pii/S0195666325002995?via%3Dihub
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Ole Christian Sylte
Eelke Snoeren
4 months ago
New preprint alert! Perinatal fluoxetine exposure increases male rat sexual behavior.
@uitnorgesarktiske.bsky.social
#neuroscience
#neuroskyence
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Ole Christian Sylte
The Transmitter
4 months ago
A non-value-based system in the brain automates decision-making and frees up cognitive resources for other tasks, a new study in mice suggests. By Holly Barker
#neuroskyence
www.thetransmitter.org/neurobiology...
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Dopamine neurons signal default behavior to reinforce habits
Movement-sensing neurons in the striatum influence a mouse’s choice of action by favoring routine behaviors.
https://www.thetransmitter.org/neurobiology/some-dopamine-neurons-signal-default-behaviors-to-reinforce-habits/?utm_source=bluesky&utm_medium=org-social&utm_campaign=20250611-dopamine-neurons-default-behaviors
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Ole Christian Sylte
Ute Häussler
5 months ago
A new paper from the group is online: we show that longterm low-frequency stimulation alleviates seizures beyond stimulation periods and reverses epilepsy-associated synaptic alterations.
#TrEPILab
www.sciencedirect.com/science/arti...
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Long-term hippocampal low-frequency stimulation alleviates focal seizures, memory deficits and synaptic pathology in epileptic mice
Mesial temporal lobe epilepsy (MTLE) is a prevalent form of focal epilepsy characterized by seizures originating from the hippocampus and adjacent reg…
https://www.sciencedirect.com/science/article/pii/S0969996125001810
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Ole Christian Sylte
Antje Kilias
5 months ago
Looking forward to an exciting Spring Hippocampal Research Conference in Verona with
@mbartos.bsky.social
@olechsylte.bsky.social
@federicotorelli.bsky.social
and
@ute-fr.bsky.social
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Ole Christian Sylte
Hugo Spiers
5 months ago
Impressive study in @nature from my colleague Marcus Stephenson-Jones at UCL in the
@sainsburywellcome.bsky.social
www.nature.com/articles/s41...
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Dopaminergic action prediction errors serve as a value-free teaching signal - Nature
Dopaminergic action prediction error signals are used by mice as a value-free teaching signal to reinforce stable sound–action associations in the tail of the striatum.
https://www.nature.com/articles/s41586-025-09008-9
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Ole Christian Sylte
Sainsbury Wellcome Centre
5 months ago
Read the full paper ‘Dopaminergic action prediction errors serve as a value-free teaching signal’ in
@natureportfolio.nature.com
@gatsbyucl.bsky.social
@imperialcollegeldn.bsky.social
www.nature.com/articles/s41...
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Dopaminergic action prediction errors serve as a value-free teaching signal - Nature
Dopaminergic action prediction error signals are used by mice as a value-free teaching signal to reinforce stable sound–action associations in the tail of the striatum.
https://www.nature.com/articles/s41586-025-09008-9
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reposted by
Ole Christian Sylte
5 months ago
Congrats to Aurore Gazala for winning the Eve Marder Best Paper Prize for “Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice” (Nat Comm, 2024) - awarded in person by Eve Marder at the IN-CODE retreat in Potsdam!
@acazala.bsky.social
#interneurons
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Ole Christian Sylte
Eelke Snoeren
5 months ago
Play the "IBNS 2025 Reindeer Games Contest"! Share one of the reindeer adds on social media and get the most likes!
@ibnsconnect.bsky.social
1st prize - $100 Gift Card or $200 off IBNS Registration 2nd prize - Free one year IBNS regular membership or two years Student/Postdoc membership
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Don't miss your last chance to attend IBNS in Tromsø!
add a skeleton here at some point
5 months ago
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Ole Christian Sylte
Aurore Cazala
6 months ago
🔬🤝🎨 Drawing over my 2photon recordings of axons in the dentate gyrus for our last picture contest ✨️
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Ole Christian Sylte
Marlene Bartos
7 months ago
Check our new manuscript on ‚Coordinated representational drift supports stable place coding in the hippocampal CA1’ by Ole Sylte, Antje Kilias, Marlene Bartos and Jonas Sauer.
www.biorxiv.org/content/10.1...
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Coordinated representational drift supports stable place coding in hippocampal CA1
The phenomenon of representational drift (i.e., changing neuronal tuning during repeated exposure to the same stimuli), is a fundamental paradox in neuroscience that raises the question how stable beh...
https://www.biorxiv.org/content/10.1101/2025.02.04.636428v1
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Ole Christian Sylte
Jonas Sauer
7 months ago
New paper out! We found functional neuron classes in the mPFC with different spatial tuning properties (generalised vs. trajectory-specific) and distinct contribution to the encoding of task space. Great job by the first author Hannah!
www.cell.com/cell-reports...
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Conjoint generalized and trajectory-specific coding of task structure by prefrontal neurons
Neurons in the medial prefrontal cortex (mPFC) show spatially modulated activities. Muysers et al. show that mPFC neurons fall into distinct functional classes that differ in terms of their spatial tu...
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00191-3
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Ole Christian Sylte
Liset M. de la Prida
7 months ago
New from the lab!! 👉🏼
authors.elsevier.com/a/1kgT43BtfH...
📝
@cellpress.bsky.social
We discovered that genetically-defined neuron types in the hippocampus form unique manifolds! Dual color imaging, chemogenetics and topological analysis all at once! With Juan Gallego
@juangallego.bsky.social
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Ole Christian Sylte
Aurore Cazala
7 months ago
Slow life as a scientist
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Ole Christian Sylte
Chunyu Ann Duan
8 months ago
First preprint from our lab! An
@jerlich.bsky.social
collaboration We developed novel frameworks to study multi-agent decisions in mice. Mice flexibly shift their decision preference under social competition, by integrating real-time self and opponent information!
www.biorxiv.org/content/10.1...
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Mice dynamically adapt to opponents in competitive multi-player games
Competing for resources in dynamic social environments is fundamental for survival, and requires continuous monitoring of both 'self' and 'others' to guide effective choices. Yet our understanding of ...
https://www.biorxiv.org/content/10.1101/2025.02.14.638359v1
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Don't miss the chance to present at the world's northernmost university city while catching the midnight sun 👇
add a skeleton here at some point
8 months ago
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Stable maps from drifting neurons: CA1 solves the "representational drift paradox" through coordinated population dynamics. New preprint w/
@antjekilias.bsky.social
, Marlene Bartos and
@jf-sauer.bsky.social
showing that representational drift isn’t random—it’s structured to preserve information🧵👇
loading . . .
Coordinated representational drift supports stable place coding in hippocampal CA1
The phenomenon of representational drift (i.e., changing neuronal tuning during repeated exposure to the same stimuli), is a fundamental paradox in neuroscience that raises the question how stable beh...
https://www.biorxiv.org/content/10.1101/2025.02.04.636428v1
8 months ago
1
14
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reposted by
Ole Christian Sylte
Eelke Snoeren
9 months ago
New paper alert! We studied the temporal copulatory patterns of female rat sexual behavior and proposed a new behavioral assessment method.
#behavioralneuroscience
#UiTtheArcticUniversityofNorway
#neuroscience
www.sciencedirect.com/science/arti...
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The temporal copulatory patterns of female rat sexual behavior
Female sexual behavior is a naturally rewarding activity that plays an important role in reproduction and species survival. For female rats, regulatin…
https://www.sciencedirect.com/science/article/pii/S0376635725000105
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reposted by
Ole Christian Sylte
Ute Häussler
9 months ago
Our new preprint on long-term low-frequency stimulation in MTLE is online. We show that LFS has lasting effects on seizures even during stimulation-free periods and induces ultrastructural changes at the PP synapse.
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If you're into behavioral neuroscience and/or machine learning and looking for a postdoc, check this out - excellent lab and mentor! 👇
add a skeleton here at some point
9 months ago
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Having spent 4+ years in
@jf-sauer.bsky.social
lab - this is a fantastic opportunity! Great mentor & super exciting work on neural population code!
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9 months ago
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reposted by
Ole Christian Sylte
Mohamady El-Gaby
10 months ago
A bit late to the Bluesky party but here’s our work showing a coordinate system for behavioural space, and an algorithm for computing behavioural sequences in the mFC:
www.nature.com/articles/s41...
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A cellular basis for mapping behavioural structure - Nature
Mice generalize complex task structures by using neurons in the medial frontal cortex that encode progress to task goals and embed behavioural sequences.
https://www.nature.com/articles/s41586-024-08145-x
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