When the first sentence of a published article starts with “Certainly, here is a possible introduction for you:”, one wonders if the value of the “peer-reviewed article” currency is inflated. Amazing find by @gcabanac.cpesr.fr.

Next week, I'll give an online talk on estimands at @osi-luebeck.bsky.social. If you'd like to join, e-mail [email protected] to get the link. Excellent chance to get my hot takes & empirically confirm that my professional photos are rather outdated. osi-luebeck.de/yes-but-what...

1/2 New meta-analysis of 103 tricyclic antidepressant RCTs in n=10600 shows ➡️ all results at high risk of bias ➡️ certainty of evidence (very) low ➡️ studies lasted 12 weeks max ➡️ evidence of harmful effects compared to placebo (OR 2.78), but required information size *not* reached.