This week I wrote about a provocative new study in Mol Psychiatry. The authors claim that most studies of post-mortem human brain tissue are invalid because the gene expression patterns change. I read it closely and I am…. not convinced. See why ⬇️ open.substack.com/pub/overfitt...

New guidelines out from @alzassociation.bsky.social on the use of blood-based biomarkers. Disappointing that they are for memory centers and not primary care where I think they have the most utility helping docs triage patients for referral alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Come check out poster #745 at #AAIC and learn about how a healthy lifestyle can mitigate genetic predisposition to Alzheimer’s Disease!

🎉📄Excited to share a pre-print of my most recent PhD project: "Downward bias in the association between APOE and Alzheimer’s Disease using prevalent and by-proxy disease sampling in the All of Us Research Program" (short summary and link in replies ⬇️)

Jeremy in the trenches fighting for all of us! 👏

Really excellent keynote speaker @bionexuskc.bsky.social by Dr. Tatonetti and well said - “observation is the starting point of biological discovery.”

Congrats to @claytonmansel.bsky.social for his Nexus informatics poster receiving an honorable mention. @bionexuskc.bsky.social

Federal judge Angel Kelly has extended her hold on the NIH's overhead cut. www.forbes.com/sites/michae...

Just watched Secretary Kennedy's Speech to HHS Employees. Key takeaways: (1) NO ANNOUNCEMENT OF FIRINGS! (2) Generally positive tone about science and scientists (3) Set up some strawmen about lack of transparency but promising a new era of transparency 1/2

If you wanted to cut waste, fraud, and abuse, you would empower the inspectors general. If you wanted more waste, fraud, and abuse, you would fire them.

Defying defiance to the laws. Good for NIH!

This administration is determined to implement their priorities in the most bad-faith, disruptive way possible. If we are all about “merit” now why not just merge the Diversity F’s with the others? Ridiculous

The CSR comm I'm on just pulled all Diversity F grants from the current review cycle. These apps are reviewed alongside (and by the same criteria) as all other F grants. So, instead of helping these trainees, they will actually be punished by having their grant reviews delayed at least 1 cycle !?!?

Totally normal stuff here

The Trump Administration Appears to Be Holding the NIH Hostage www.splinter.com/the-trump-ad...

Hi, Vox reporter here: If you've had a study section, NIH travel, or other NIH-related meeting cancelled (or not), raise your hand! Reply or DM me, and repost for visibility if you're able. #academicsky @drugmonkey.bsky.social

This going to be so good and probably one of the most useful streetcar routes in the U.S. Can’t wait to ride!

We are absolutely swooning over these pics of #kcstreetcar 807 rolling through the Plaza on its 1st ever test run. 😍

One day, one toe in the water with Ambient AI Scribes. Interesting. I did not find it to be a game changer for documentation burden, but perhaps it is a paradigm shift back to being able to capture patient stories with detail and expressivity in a way busy clinicians may struggle to do. 9/x

Excited to share a preprint of my first project from my PhD: Distinct Medical and Substance Use Histories Associate with Cognitive Decline in Alzheimer's Disease! 🧠 doi.org/10.1101/2024...

I’m no fan of echo chambers but the critics of movers to Bluesky under-appreciate: 1) X has become the same thing but for the other side 2) X’s culture has bent to the whims of its owner (which is fine! But he’s not my style) 3) X’s algorithm rewards divisive, loud, controversial takes.

Just yesterday I was scrolling at the *other* place and lamenting that institutions like my library haven’t made the switch… well, today is a new day! Welcome KC library @kclibrary.bsky.social ! 📚 Maybe bsky will become a thing after all

First day on Bluesky and @theverge.com has reactivated their account and Mark Cuban is posting about RSS feeds and I am so here for it