Online now: Oxygen-atom replacement in non-strained cyclic ethers

Happy to share a new way of promoting dual-atom insertion into oxetanes and azetidines to access multi-heteroatom rings using FLP chemistry, just out in @natsynth.nature.com nature.com/articles/s44... #skeletalediting #ringexpansion #FLP

We show that native sugars can be directly merged with N-heteroarenes via redox-active thioglycosyl radical precursors using photocatalysis. Great collaboration with the Chan group from NUS Pharmacy to study the bioactivity of these compounds. #glycotime www.nature.com/articles/s44...

Electrifying skeletal editing? Our latest work on a tunable electrochemical method that enables divergent N-heterocycle synthesis via N insertion into carbocycles. #skeletalediting #expansion #electrochemistry #heterocycle

Now online: Article by Yu Zhao, Ming Joo Koh & co-workers Divergent synthesis of N heterocycles from carbocycles enabled by electrochemical nitrogen atom insertion www.nature.com/articles/s44... ($) #Chemsky

Another week, another atom swap! This one features adorable--and adorably versatile--oxetanes! cen.acs.org/synthesis/At...

A new photocatalytic atom-swapping method enables efficient conversion of oxetanes into diverse four-membered saturated rings, streamlining access to key pharmaceutical building blocks. doi.org/g96442

Swapping oxygen in oxetanes? 🪄 Done! With skeletal editing 🙌🏼🦴✨ My latest @chemistryworld.com story covers a cool strategy to introduce nitrogen, carbon, or sulfur instead at a single stroke 🖌️🎨 Amazing, almost magic @nature.com paper by @mjkoh87.bsky.social 👉🏼 www.chemistryworld.com/news/stimula...

Atom-swapping in a saturated heterocycle? We report a photocatalytic transmutation strategy in @nature.com that exchanges O within an oxetane for N, S, C & even dual atoms, affording various non-aromatic cyclic pharmacophores. #skeletalediting #atomswap #photocatalysis www.nature.com/articles/s41...

Now online: Review article by Achyut R. Gogoi, Ángel Rentería-Gómez, Tong-De Tan, Jun Wei Ng, Ming Joo Koh & Osvaldo Gutierrez Iron-catalysed radical difunctionalization of alkenes www.nature.com/articles/s44... ($) #Chemsky

Applications are now open for the Stanford Science Fellows postdoctoral program, opportunity to join an exciting community of scholars! stanfordsciencefellows.stanford.edu

Cool to have Todd Hyster from Princeton University with us today at NUS Chemistry in Singapore. Photo credits: Jie Wu, Yu Zhao. #photoenzymatic #catalysis

It's a privilege to have Marisa Kozlowski from @pennchemistry.bsky.social with us today at NUS Chemistry in Singapore. Photo credit: Yixin Lu. #organicchemistry #OrgLett

Excited to see our recent difluorocarbene skeletal expansion chemistry being used to make a molecule of the week! Read more about making difluorooxetanes from here: lnkd.in/gad_5fNq Now available from Enamine: new.enaminestore.com/catalog/EN30...

A new skeletal expansion approach to make γ-lactam pharmacophores by Cu-catalyzed difluorocarbene insertion into azetidines. It turns out that some γ-lactam scaffolds are harder to access than azetidines. Just accepted in @angewandtechemie.bsky.social. onlinelibrary.wiley.com/doi/10.1002/...

Our latest work in @naturechemistry.bsky.social using copper catalysis to promote difluorocarbene insertion into epoxides, allowing us to access an interesting but elusive class of α,α-difluoro-oxetane pharmacophores. www.nature.com/articles/s41...