First Pipeline post of the year! A statement of purpose, and science topics resume on Monday:

Parece que el flamante premio FIFA de la paz va empezar una guerra

Thanks to @actacrystf.iucr.org for highlighting our smart 2D selection tool CryoSift. You can test it yourself here cryosift.org

You can do this right now: Think of a person who wrote a paper you love, whose work influenced or helped you, or has made your professional life better. Search up their email address. Shoot them a quick email of thanks. It means so, so much. This is a rough time of year, share some joy.

We have many other interviews you might find interesting – please have a look at our playlist and give them a watch, there are lots of interesting stories to discover: www.youtube.com/playlist?lis...

CryoSift uses a Convolutional Neural Network (CNN) for assessing the quality of 2D averages to enable the automatic selection of suitable particles for high-resolution reconstructions. The interview discusses aspects such as how to avoid bias, dealing with errors, automation in Cryo-EM and others.

New interview alert! We had a chat with Mike Cianfrocco, Scott Stagg and Jan-Hannes Schäfer about their CryoSift tool – details in the thread. www.youtube.com/watch?v=ROlc...

Trump Announces 5,000% Increase In All Numbers — theonion.com/trump-announ...

November issue out now: journals.iucr.org/f/issues/202... On the cover: the structure of the kinetically slow and catalytically impaired Gln143Asn mutant of human mitochondrial MnSOD leads to the observation of transient hydrogen peroxide-bound states. More at shorturl.at/41Mb9

40% dierstudies naar hersenbloedingen bevat afbeeldingen die niet kloppen, ontdekten René Aquarius en Kim Wever @radboudumc.bsky.social. Sommige artikelen zijn mogelijk geheel of deels verzonnen. Zorgwekkend, zegt ook @elisabethbik.bsky.social. Voor @voxweb.bsky.social. www.voxweb.nl/nieuws/honde...

That merely being “under review” by a Nature family journal is offered as a quality proxy for a paper is a tragic illustration of the extent to which academia is addicted to brands and outsources evaluation

Letter to the editor: Remember the red bus? Brexiters said EU money would go to the NHS. Instead, our most deprived communities lost billions in EU investment – and got slogans about “pride” instead.

Dr. Jane Goodall filmed an interview with Netflix in March 2025 that she understood would only be released after her death.

D​ouglas H. Juers et al.: Automated gradient equilibration of macromolecular crystals to new solution conditions ##Crystal##Solution##Cracking... ##IUCrhttps://journals.iucr.org/paper?S2053230X25008398

WE. NEVER. GIVE. UP. 👊

Happy that I have finally published this work at @epljournal.bsky.social which calculates the distribution of pandemic extinction times using only NPIs (yes lockdowns) & predicts that the covid pandemic could have been eliminated in a time of order months! iopscience.iop.org/article/10.1... ⚛️🧪

I'm incredibly proud to present this @actacrystf.iucr.org interview with Alex Mendez and Cydni Bolling on their first paper ever! The interview was co-led by Dr Graham Chakafana from Hampton University in the USA, who supervised the authors' undergraduate research. www.youtube.com/watch?v=5rjI...

It was foolish for Russell to approach the hornets’ nest in the first place, but his timing was particularly bad.

📣 The #GE3C has awarded the Gold Medal 🎖️, its highest distinction, to Professor Santiago García Granda, from the University of Oviedo and President of the IUCr, in recognition of his extensive and outstanding 🔝 scientific career in the field of crystallography 💎.

The crystal structure of Fasciola hepatica TPI has been solved at 1.51 Å and used to perform molecular-docking studies with the most successful fasciolocide triclabendazole #FasciolaHepatica #TriosephosphateIsomerase #TPI doi.org/10.1107/S205...

Virulence protein J domain 1 maintains the canonical α/β-hydrolase fold but is likely to lack a functional catalytic triad, suggesting functional divergence from classical hydrolases of this superfamily #BacterialPathogens #TypeIVSecretionSystem doi.org/10.1107/S205...

Our September issue is available! tinyurl.com/58x22mpx The cover shows the crystal structure of the N-terminal domain 1 of virulence protein J from Brucella abortus, which adopts an α/β-hydrolase fold but lacks the characteristic catalytic triad: see tinyurl.com/bdduy23d

My quote of the day Nobody ever thanks you for saving them from the disease they didn't know they were going to get. William Foege

Dear Americans, welcome to the thrilling game of ‘Did this dictator die or just disappear for a day?’ We’ve been playing it with Putin and Lukashenko for decades. Enjoy the suspense.

🚗 Black cars amplify city heat Parked cars intensify the urban heat island effect. In Lisbon, a black car heated nearby air by up to 3.8 °C more than the asphalt beneath it. Light colours and shading cut the effect. 🔗 www.zmescience.com/ecology/clim... #SciComm #Cars 🧪

Posts about research on Bluesky receive substantially more attention than similar posts on X, formerly called Twitter go.nature.com/45Ftiw4

It's great to see NSMB following the lead of IUCr journals like Structural Biology (@actacrystd.iucr.org) and Structural Biology Communications (@actacrystf.iucr.org). Reviewers find it much easier if they don't actually have to ask for the experimental data! Here's hoping other journals follow.

Whether you're just starting out or well established in your field, adding your name helps build visibility, collaboration and community. Join the World Directory of Crystallographers. It's free! Sign up today and connect with peers worldwide: www.iucr.org/people/wdc

Just realised that we've been doing Interviews With Authors on YouTube for a whole year! I'd really appreciate receiving comments about these, e.g. suggest a structural biologist you would like us to interview Here's a playlist with all the videos we've done so far: www.youtube.com/playlist?lis...

Chloé Dugelay et al.: Crystal structure of the virulence protein J (VirJ) domain 1 from Brucella abortus ##BacterialPathogens##EsteraseFold##TypeIVSecretionSystem... ##IUCrhttps://journals.iucr.org/paper?S2053230X25006697

Sorry, it is in Spanish.. x.com/i/status/195...

www.theguardian.com/commentisfre... Not just in the UK, everywhere!