📣Updated ESMO #ClinicalPracticeGuideline on advanced and metastatic #ProstateCancer: ✅ Substantial advances in castration-sensitive & -resistant prostate cancer ✅ Updated algorithms & recommendations reflecting latest clinical data #ESMOGuidelines Christopher Sweeney 🔗 https://ow.ly/E4ov50Yc8e2

🧬 New preprint out! Dilara Akhoundova and team identify AURKA as a synthetic lethal vulnerability in FANCA-deficient cancers using complementary CRISPR and drug screens. 🔗 doi.org/10.64898/202... #PrecisionOncology #SyntheticLethality #FANCA #AURKA #CancerGenomics

Molecular Cancer Research editor Massimo Loda, Franklin W. Huang, Michael C. Haffner, and Irene Paassen discussed "Genomics and Epigenomics" in a plenary session at the AACR Special Conference on Innovations in Prostate Cancer Research and Treatment. #AACRprostate26 @aacrjournals.bsky.social

Can we help men with hormone-refractory #ProstateCancer through personalized epigenetic therapy? Our new study using patient-derived organoids reveals a targetable weakness in a WNT-driven subtype. @genentech.bsky.social @medfacultyunibe.bsky.social @unibe.ch @pmbern.bsky.social tinyurl.com/2tkn3hwh

New @natmed.nature.com News & Views by @marubin1.bsky.social and Dr. Irene Paassen on why #PrecisionOncology must go beyond genomics. @medfacultyunibe.bsky.social @pmbern.bsky.social tinyurl.com/2zvdvmy6

📣 Updated ESMO #ClinicalPracticeGuideline on local & locoregional #ProstateCancer: ✅New imaging modalities: Improved diagnosis, staging & risk stratification ✅Updated algorithms: less over-Tx & fewer side-effects #Oncology #UroOncology #CancerCare #ESMOGuidelines 🔗 https://ow.ly/jwA650XLs1q

Excited to share new preprint on the minor spliceosome in cancer! Targeting U6atac disrupts DNA repair and sensitizes prostate & breast tumors to radiation, cisplatin and PARP inhibitors—even beyond BRCA-mutant . bit.ly/48RnsI5 #DNARepair #ProstateCancer #BreastCancer #U6atac @theaacr.bsky.social

Congrats to Jia and Michael and team. This has been a major effort and we are learning so much about lineage plasticity www.nature.com/articles/s41....

I Used to Run the N.I.H. Here’s What Worries Me. www.nytimes.com/2025/02/14/o...