Paper of the week by my last PhD student, Morgan Bucknor! Morgan's research focused on developing a triple-hit murine model of NDDs and used a range of high-res tech to examine the impact on transcriptome and proteome in brain and blood! Super proud! www.biorxiv.org/content/10.1...

My brain, oh my brain, tell me what drugs I'm on! Classification of psychedelics and psychoactive drugs based on brain-wide imaging of cellular c-Fos expression www.nature.com/articles/s41...

Paper of the week: "A molecular mechanism mediating clozapine-enhanced sensorimotor gating." Really nice paper, starting with basic behavioural phenotyping, then gradually using more complex techniques. www.nature.com/articles/s41...

Paper of the week: "Transcriptomic Regulation by Astrocytic m6A Methylation in the mPFC." onlinelibrary.wiley.com/doi/10.1111/...

Being patient with the biology of addiction Advancing laboratory discoveries into treatments is taking decades for cancer, and doing so for addiction will take longer, given the brain’s far greater complexity www.science.org/doi/10.1126/...

Paper of the week: "Dorsal BNST GABA neurons are necessary for chronic unpredictable stress-induced depressive behaviors in adolescent male mice." Activation induces depressive-like behaviours, inhibition alleviates CUS-induced depressive-like behaviours. www.sciencedirect.com/science/arti...

Already a lot of great discussion of this paper on here, but the enrichment of neuropsychiatric disease burden genes in "eccentric" MSNs is really intriguing to me. www.nature.com/articles/s41...

Paper of the week: "Deletion of murine astrocytic vesicular nucleotide transporter increases anxiety and depressive-like behavior and attenuates motivation for reward." Loss of vNut in the female nAC leads to increased FST immobility and decreased sucrose preference. www.nature.com/articles/s41...

My paper of the week: "The modified elevated gap interaction test: a novel paradigm to assess social preference." royalsocietypublishing.org/doi/10.1098/...

"Multi-level therapeutic actions of cannabidiol in ketamine-induced schizophrenia psychopathology in male rats." It's been more than a decade since I did my PhD on CBD. This is amazing work identifying MOA for CBD's therapeutic potential. www.nature.com/articles/s41...

Teacher: What is the first rule of thermodynamics? Me: We don't talk about thermodynamics

"Understanding the neural code of stress to control anhedonia." Very cool paper showing role of CA1-BLA circuit in mediating response to stress. www.nature.com/articles/s41...

Watching the West Wing for the second time round. Would not have thought it would make so emotional. For the times in which we live in, watching the series gives me hope. #westwing