Neglected Global Diseases Initiative at UBC (@ngdiubc.bsky.social)

The scientists fighting to stop the antibiotic apocalypse Antibiotics are losing their effectiveness. With the growth of antimicrobial resistance, routine treatments could become impossible owing to the risk of infection. Cancer treatments, care of newborns and routine surgeries are all in danger if this trend isn’t curbed and millions of people are already dying from infections by antibiotic-resistant bacteria. This resistance rise won't only cost lives. In 2023, the World Bank estimated that antimicrobial resistance could increase health-care costs by US$1 trillion by 2050. So, researchers are urgently looking for solutions. Some of these might come from surprising places, and this has led researchers to investigate organisms at the planet's extremes. Other scientists, however, have discovered a source of antibiotic-producing bacteria closer to home — at the grave of a faith healer. While some researchers have turned to traditional folk stories for clues in the search for new medicines, others have been using artificial intelligence to speed up the discovery process for antibiotics, to help deliver drugs into bacteria and to help physicians decide when to prescribe antibiotics to help prevent their overuse. Together, this research could unlock new antibiotics and find ways to make them last longer, avoiding a future in which bacterial infections make a resurgence. 00:00 The rise of antibiotic resistance 01:23 Investigating a grave for new antibiotics 04:13 Analyzing the grave soil in the lab 07:13 The need for new approaches 09:37 The promise of AI to find new antibiotics 10:32 Using AI to discover chemical tricks to get drugs into bacteria 14:13 How AI could be used to help prescribe antibiotics and prevent resistance 17:30 Researchers' hopes for the future Read more: https://go.nature.com/4nqK3Cg Subscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday: https://go.nature.com/4dakKB5 This Nature Video is editorially independent. It is produced with third party financial support. Read more about Supported Content here: https://go.nature.com/3Rcp36e https://go.nature.com/4flL64o