Michael Nicholson (@mdnicholson1.bsky.social)

Happy to share our recent work quantifying ‘just-right’ APC inactivation in colorectal cancer initiation: doi.org/10.1158/0008... Excellent collaborative teamwork, led by the fantastic Meritxell Brunet Guasch.

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Mathematical Modeling Quantifies “Just-Right” APC Inactivation for Colorectal Cancer Initiation Mathematical modeling of tumor development with different APC genotypes substantiates the “just-right” APC inactivation model and suggests alterations in secondary WNT regulators enhance WNT activity ... https://doi.org/10.1158/0008-5472.CAN-25-0445