Valeria Robleto, PhD (@valeriarobleto.bsky.social)

Can we design allosteric modulators that change a GPCR's preferred G protein? Yes!💥 BAMs at the GPCR-transducer interface change G protein subtype selectivity in predictable ways, enabling rational drug design. The lab's 1st preprint! Check it out! 🧪💊🧠🟦https://doi.org/10.1101/2024.11.20.624209 🧵👇

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Design of allosteric modulators that change GPCR G protein subtype selectivity G protein-coupled receptors (GPCRs), the largest family of drug targets, can signal through 16 subtypes of Gα proteins. Biased compounds that selectively activate therapy-relevant pathways promise to ... https://doi.org/10.1101/2024.11.20.624209