we've seen customers reaching back to physics based methods in order to solve their molecular modeling problems. In our latest post we explore how you can use the Rosetta "pocket opener" method with Boltz-2 to generate better protein-ligand models than Boltz-2 alone levitate.bio/boltz/ai/ml/...

How to train your model. This immersive, hands-on, advanced-level event is designed for researchers who are ready to move beyond “out-of-the-box” machine learning models for protein design. Join us for this Summer RosettaCon 2025 workshop/hackathon, more here: rosettacommons.org/2025/05/30/h...

As @rolanddunbrack.bsky.social recently discovered, one of the issues with the ipTM score used AF2 to represent the ipTM score is that it is biased by disordered regions of the protein outside the binding interface. To address this, he implemented a new metric, ipSAE. levitate.bio/alphafold/mu...

there are still some real downsides to not actually modeling the physics

De novo #ai protein binder design with levitate.bio! Watch this video to see how it is done, with no code, no scripts, all in an easy to use GUI in the browser. youtu.be/87U_g8awaEE?...

BindCraft is a new AI de novo binder design tool from the Correia lab with 10-100% success rates. It's available today as an easy to use API using our API framework so you can deploy it in your own pipeline today. Contact us at levitate.bio/contact to get started www.biorxiv.org/content/10.1...

RFDiffusion is great for de novo design but it can be a bit frustrating to use. Check our our new GUI for making de novo binder design fast and easy! www.youtube.com/watch?v=rwpL...

Come work with us! We're hiring a Scientific Sales Specialist. This is the perfect job if you've got a BS in biology or biochemistry and are looking to start a career in software sales. No sales experience is necessary. For more details on the job and how to apply go to levitate.bio/careers

I sometimes forget how flexible proteins are. It becomes really apparent when you use NMR states for an animation. That poor cofactor is getting pushed around a lot 😅 #sciart #blender3d #biocatalysis

Quiz: Side chains R K E Q I M have 9 chi1+chi2 rotamers. They are: {g+g+} {g+t} {g+g-} {tg+} {tt} {tg-} {g-g+} {g-t} {g-g-}. 4 of these have high energy & v. low populations compared to rest. Which 4? Why? Leu has only 2 good rotamers. Which ones? why? Good struct bio final exam Question.

Beyond excited to introduce AlphaQubit, now published in Nature! AlphaQubit is a neural network for quantum error correction and achieves state-of-the-art accuracy on simulated and real-world data.

Here's an interesting new paper from IPD: www.biorxiv.org/content/10.1... Cyclic peptides are a compelling format for a drug but a lot of computational design tools don't handle them well. Here they modified AF2 and RFDiffusion with a rotational encoding 1/

Hello! We're a software company which spun out of Cyrus Bio. We sell cloud based tools to help make state of the art protein engineering and modeling methods more accessible. We're owned by the Rosetta Commons Foundation which will use our profits to support academic research. levitate.bio